Amphiphilic silver-delaminated clay nanohybrids and their composites with polyurethane: physico-chemical and biological evaluations

Abstract

Silver nanoparticles (AgNPs) exhibit size-dependent bactericidal activity. They are, however, subject to aggregation when added to most hydrophobic polymers. In this study, a surfactant-modified delaminated clay (surfactant-capped nanosilicate platelets, or "NSQ") was employed to be a nanocarrier for AgNPs. The nanohybrid of AgNPs and NSQ ("AgNP/NSQ") in aqueous solution showed remarkable bactericidal effect as well as negligible cytotoxicity and immune response at a concentration of 10 ppm.Poly(carbonate)urethane (PCU) with different hard/soft segment ratios was synthesized and used in the preparation of the nanocomposites, PCU-AgNP/NSQ. Based on TEM observation, AgNP/NSQ was well dispersed in the resulting nanocomposites. The reinforcing effects of AgNP/NSQ in nanocomposites were distinct for PCU with different hard/soft segment ratios. The phase-separated structure of PCU-AgNP/NSQ nanocomposites was investigated by small-angle X-ray scattering (SAXS). PCU-AgNP/NSQ containing 75 ppm of Ag demonstrated superior microbiostatic effect, as well as better biodurability and lower foreign body reaction than the commercial Pellethane 2363-80A.

Green silver nanobioarchitectures with amplified antioxidant and antimicrobial properties

“…On the other hand, the small size and good dispersion state (non-aggregation) of a sample are favorable factors for bacteriostatic activity. 16,63 Thus, according to DLS and zeta potential measurements, the silver-containing structures (see samples B and D) exhibited lower dimensions and higher stability than liposomes alone.…”

“…13 Nanocomposites based on nano-silver exhibit enhanced antibacterial properties. 14,15 Recently, superior microbiostatic effects of AgNPs were exploited to construct novel silver-based nanocomposites 16 and silver nanoparticle-lled nylon-6 nanobers 17 with improved antibacterial properties.…”

Synthesis of water-dispersible zinc oxide quantum dots with antibacterial activity and low cytotoxicity for cell labeling

“…However, none of them significantly reduced bacterial growth at 1 ppm. In comparison to the antibacterial properties of silver NPs at low concentrations [40], ZnO QDs were not as effective. It was worth mentioning that at the concentration of 15 ppm the antibacterial efficacy of ZnO-HMA QDs was better than the PEGylated ZnO QDs.…”

“…On the day of the experiment, the culture medium was replaced by the medium containing water-dispersible ZnO QDs at 30 ppm for 2 h and then incubated with 20 µM 2 ,7 -dichlorodihydrofluorescein diacetate (DCFH-DA) for 30 min. After DCFH-DA was removed, cells were washed with phosphate-buffered saline (PBS) and the fluorescence was detected using an excitation wavelength of 488 nm and an emission wavelength of 530 nm with the multi-detection microplate reader and normalized to the blank [40].…”

Evenly Distributed Thin-Film Ag Coating on Stainless Plate by Tricomponent Ag/Silicate/PU with Antimicrobial and Biocompatible Properties

“…The conventional AgNP was studied for its safety issues in addition to its antimicrobial activities. ,,, The AgNP/NSP blended with food diets were demonstrated for the biocompatibility and antimicrobial activities in vivo and in vitro. ,, Here, we address the safety issue of the PU-blended AgNP/NSP nanohybrid at a 1/1 ratio. The cytotoxicity with mammalian cells was tested by a AgNP/NSP–PU coating amount of 10 mg on the surface area (1 cm 2 ) of the stainless steel plate in our research.…”