Amphiphilic segmented polymer networks based on poly(2-alkyl-2-oxazoline) and poly(methyl methacrylate)

Christova, Darinka; Velichkova, R.; Goethals, Eric J.; Prez, Filip Du

doi:10.1016/s0032-3861(02)00313-0

Cited by 44 publications

(44 citation statements)

References 10 publications

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“…These are two-component networks composed of hydrophilic and hydrophobic segments, forming well-defined nanostructures by microphase separation. Thus, they swell in both aqueous and organic solvents [6,12,15,17,24,25]. Besides, substances can be entrapped in hydrophilic and/or hydrophobic domains, and they can therefore be used for protein adsorption [4], as nanoreactors for enzymes [20] or for the formation of inorganic nanoclusters [25].…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic single and double networks: a small-angle X-ray scattering investigation

et al. 2016

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We investigated the microphase-separated morphologies of water-swollen amphiphilic single and double polymer networks using small-angle X-ray scattering (SAXS). The networks consist of (i) a first conetwork containing hydrophobic blocks from either 2-ethylhexyl methacrylate (EHMA) or lauryl methacylate (LauMA) and hydrophilic blocks from 2-(dimethylamino)ethyl methacrylate (DMAEMA) and (ii) a second polyacrylamide (PAAm) network. The SAXS curves are modeled by spherical core-shell micelles, where densely packed hydrophobic cores are surrounded by swollen hydrophilic chains. The correlation between these hydrophobic cores is described using a hardsphere structure factor. A Porod law and an Ornstein-Zernike structure factor are adopted to capture the strong forward scattering due to large-scale inhomogeneities and the correlation between polymer strands, respectively. The size of the hydrophobic cores depends on the degree of polymerization of the hydrophobic block: for medium and long hydrophobic blocks, several hydrophobic cores merge together to form a larger core. When the second PAAm network is present, the nanostructures of the first amphiphilic network are less welldefined.

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Section: Introductionmentioning

confidence: 99%

Amphiphilic single and double networks: a small-angle X-ray scattering investigation

et al. 2016

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“…These facts are coincident with other reports about amphiphilic networks. [14][15] Therefore, it may be concluded that CN structure was formed (Fig. 1).…”

Section: Resultsmentioning

confidence: 95%

A novel shape memory polymer based on conetworks

Pan

Zhang

et al. 2009

E-Polymers

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A novel shape memory polymer based on conetworks (CNs) was synthesized. These conetworks consisting of poly(methyl methacrylate) and poly (ethylene glycol) diacrylates showed excellent shape-memory properties with a recovery ratio of nearly 100%. Moreover, different shape memory effects were discovered in different mediums due to their amphiphilic properties. In addition, a large storage modulus ratio above and below the glass transition temperature(E ratio ), which probably means excellent shape memory effect, were obtained due to the designed CN structure whether crystallization existed or not. It is quite different from the traditional methods to achieve large E ratio values. The versatility of shapememory conetworks potentially provides us a new route to prepare shape memory materials.

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“…SCNs were prepared by UV-induced radical copolymerization of poly(2-ethyl-2-oxazoline)-α,ω-diacrylate with corresponding comonomers (2-hydroxyethyl methacrylate, hydroxypropyl acrylate, and methyl methacrylate) as described previously (23,30). The PEtOx-α,ω-diacrylate was synthesized according to the earlier reported procedure (31).…”

Section: Experimental Section Materialsmentioning

confidence: 99%

“…Poly(2-oxazoline)s are synthesized by living cationic ring-opening polymerization of 2-substituted-2-oxazolines and physicochemical properties depend on the substituent in the oxazoline ring, as well as the macromolecular structure and composition (17)(18)(19). In order to modify the properties and further enlarge the area of potential applications of poly(2-oxazolines), the efforts are directed towards the synthesis of various block and star copolymers, segmented copolymer networks (also known as conetworks), and so on (20)(21)(22)(23). However, the use of poly(2-alkyl-2-oxazolines) in drug delivery so far is not well covered, and the research is focused mainly on the systems which increase the solubility of hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tartrate Delivery Systems

et al. 2014

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Abstract. Segmented copolymer networks (SCN) based on poly(2-ethyl-2-oxazoline) and containing 2-hydroxyethyl methacrylate, 2-hydroxypropyl acrylate, and/or methyl methacrylate segments have been evaluated as potential sustained release systems of the water soluble cardioselective β-blocker metoprolol tartrate. The structure and properties of the drug carriers were investigated by differential scanning calorimetry, attenuated total reflectance Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy. Swelling kinetics of SCNs in various media was followed, and the conditions for effective MT loading were specified. MT-loaded SCNs with drug content up to 80 wt.% were produced. The release kinetics of metoprolol tartrate from the systems was studied and it was shown that the conetworks of different structure and composition are able to sustain the metoprolol tartrate release without additional excipients.

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Amphiphilic segmented polymer networks based on poly(2-alkyl-2-oxazoline) and poly(methyl methacrylate)

Cited by 44 publications

References 10 publications

Amphiphilic single and double networks: a small-angle X-ray scattering investigation

Amphiphilic single and double networks: a small-angle X-ray scattering investigation

A novel shape memory polymer based on conetworks

Evaluation of Poly(2-Ethyl-2-Oxazoline) Containing Copolymer Networks of Varied Composition as Sustained Metoprolol Tartrate Delivery Systems

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