Amphiphilic porphyrin-based supramolecular self-assembly for photochemotherapy: From molecular design to application

Wang, Shuping; Huang, Xuechun; He, Yunhong; Zhang, Haotian; Zhou, Jun; Tang, Guping; Li, Shijun; Bai, Hongzhen

doi:10.1016/j.nantod.2022.101732

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…Thus, peptides in general have been recognized as promising candidates for biomedical applications. 140,141 Porphyrinated nanofibers were constructed on tumor sites from the peptide-porphyrin conjugates. Yan and co-workers have reported the peptide based supramolecular photodynamic metallonanodrugs based on porphyrinoids for anticancer photodynamic and photothermal therapy.…”

Section: Rsc Medicinal Chemistry Reviewmentioning

confidence: 99%

Applications of supramolecular assemblies in drug delivery and photodynamic therapy

Nisa,

Lone,

Arif

et al. 2023

RSC Med. Chem.

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Section: Rsc Medicinal Chemistry Reviewmentioning

confidence: 99%

Applications of supramolecular assemblies in drug delivery and photodynamic therapy

Nisa,

Lone,

Arif

et al. 2023

RSC Med. Chem.

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“…Target-derived cancer cells exhibit exceptional stability, self-recognition, and immune evasion capabilities owing to the presence of the CCM. More [163] Copyright 2022, Elsevier Ltd. b) PDT-CDT. Reproduced with permission.…”

Section: Chemotherapymentioning

confidence: 99%

“…Interestingly, CCM‐NPs successfully mediated the intracellular delivery of Nrf2‐siRNA and induced selective absorption by OTSCC cells. Finally, PDT based on a combination of chemotherapy, [ 163 ] CDT, [ 164 ] and ST [ 165 ] using CCM‐NPs has been frequently reported ( Figure ).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Cancer Cell Membrane‐Based Materials for Biomedical Applications

Lu,

Fan,

Wang

et al. 2023

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The nanodelivery system provides a novel direction for disease diagnosis and treatment; however, its delivery effectiveness is restricted by the short biological half‐life and inadequate tumor targeting. The immune evasion properties and homologous targeting capabilities of natural cell membranes, particularly those of cancer cell membranes (CCM), have gained significant interest. The integration of CCM and nanoparticles has resulted in the emergence of CCM‐based nanoplatforms (CCM‐NPs), which have gained significant attention due to their unique properties. CCM‐NPs not only prolong the blood circulation time of core nanoparticles, but also direct them for homologous tumor targeting. Herein, the history and development of CCM‐NPs as well as how these platforms have been used for biomedical applications are discussed. The application of CCM‐NPs for cancer therapy will be described in detail. Translational efforts are currently under way and further research to address key areas of need will ultimately be required to facilitate the successful clinical adoption of CCM‐NPs.

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“…The tetrasubstituted porphyrin shows a weak chirality; however, the optical activity could be enhanced through controlled self-assembly. The mechanism as well the nature of molecular interactions during the self-assembly was investigated in detail, fitting to supramolecular polymerization models. − Mirror image CPL signals could be obtained for nanostructures possessing opposite chirality, thereby opening newer opportunities in the chemistry of optically active porphyrins (Figure ).…”

mentioning

confidence: 99%

Binaphthalene-Assisted Axial Chirality in Porphyrins: Toward Solid-State Circularly Polarized Luminescence from Self-Assembled Nanostructures

Jadhav,

Cheran,

Dutta

et al. 2024

J. Phys. Chem. Lett.

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Circularly polarized luminescence (CPL) is emerging as an effective tool to study the excited-state optical activity in molecules and their self-assembled nanostructures. Chiral porphyrins are a class of optically active molecules wherein the ground-state chirality has been extensively studied in recent times using circular dichroism (CD) spectroscopy. However, obtaining CPL from porphyrin nanostructures, which would have vast implications in biological applications, has remained an uphill task. In this work, we design and synthesize a pair of chiral porphyrin enantiomers functionalized by axially chiral binaphthalene units at the four meso-positions. The molecule undergoes self-assembly following an isodesmic polymerization model, leading to the formation of a spherical nanostructure possessing opposite chirality. Favorable thermodynamic parameters achieved through the controlled experimental conditions helped drive the self-assembly in the forward direction. The limitations imposed by a large nonradiative decay constant arising due to the aggregation-induced quenching could be overcome by fabricating self-standing polymeric films of the nanostructures. The films exhibited relatively high radiative decay and, more interestingly, good CPL activity with clear mirror image spectra for the nanostructures with opposite chirality. The work on CPL-active solid-state materials opens avenue for the design and synthesis of a variety of porphyrin-based chromophoric systems and their nanoaggregates that can find potential application in the field of chiral biosensing and bioimaging, security tags, and display devices.

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Amphiphilic porphyrin-based supramolecular self-assembly for photochemotherapy: From molecular design to application

Cited by 10 publications

References 53 publications

Applications of supramolecular assemblies in drug delivery and photodynamic therapy

Applications of supramolecular assemblies in drug delivery and photodynamic therapy

Cancer Cell Membrane‐Based Materials for Biomedical Applications

Binaphthalene-Assisted Axial Chirality in Porphyrins: Toward Solid-State Circularly Polarized Luminescence from Self-Assembled Nanostructures

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