Applications of supramolecular assemblies in drug delivery and photodynamic therapy

Abstract

Supramolecular assemblies based on various functionalized hexa-cata-hexabenzocoronenes, hexa-peri-hexabenzocoronenes, coronenes, cyclodextrins, and pillarenes are discussed. It is anticipated that these assemblies will be viable candidates for photodynamic therapy.

Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[n]uril assemblies for medical applications

“…The applied supramolecular method proved to be superior because it allowed for exact control of the ratio of camptothecin (CPT) to cisplatin (Pt), two drugs which often could not be precisely regulated in different delivery systems. 288 Among cucurbit[n] uril-based amphiphiles 289,290 that self-assemble into nanomaterials as functional supramolecular micelles (FMS), many examples of ADA/CB[n] system could be employed for perspective biological and technological application, 291 more specifically, for cell-targeted drug delivery 292 or even as multifunctional theranostic agents for synergistic photodynamic therapy and hypoxia-activated chemotherapy. 293 In these examples FSMs exhibited favorable characteristics such as high bioavailability, stability, precise targeting, and excellent delivery efficiency, making them highly promising for use in the drug delivery domain.…”