Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: In vitro cytotoxicity and in vivo acute toxicity study

Kuskov, Andrey; Kulikov, Pavel P.; Goryachaya, A. V.; Tzatzarakis, Manolis; Docea, Anca Oana; Velonia, Kelly; Shtilman, Mikhail I.; Tsatsakis, Aristidis

doi:10.1016/j.nano.2016.11.006

Cited by 43 publications

(19 citation statements)

References 32 publications

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“…It was found that, metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) at the dose of 2 mM markedly decrease cancer volume which considered a promising approach for glioblastoma multiforme treatment [ 3 ]. Further, Kuskov et al [ 4 ], detected a new nanoparticles of amphiphilic poly -N- vinylpyrrolidone which can be used as good carriers for novel, highly efficacy, systems of hydrophobic drug delivery such as indomethacin. Silymarin loaded Poly (3-HydroxyButyrate-co-3-HydroxyValerate) (PHBHV) nanocarriers markedly reduced viability of HT-29 cells post 6 and 24 h of medications.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

et al. 2018

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“…Furthermore, it has been shown that nanoparticles are perfect match for tumor targeting due to their ability to penetrate the leaky neo-vasculatures and accumulate as a result of the poor lymphatic drainage of solid tumors (Fang et al, 2011 ; Maeda et al, 2013 ). In this view, an important number of nanoparticle formulations of different compositions are being evaluated as anticancer drug delivery systems and are currently in clinical trials for a large spectrum of medical applications, including the targeting of solid tumors (Hrkach et al, 2012 ; Veiseh et al, 2015 ; Kim et al, 2016 ; Kuskov et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Poly(HydroxyButyrate-co-HydroxyValerate) (PHBHV) Nanocarriers for Silymarin Release as Adjuvant Therapy in Colo-rectal Cancer

et al. 2017

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The aim of this study was to address one of the major challenges of the actual era of nanomedicine namely, the bioavailability of poorly water soluble drugs such as Silymarin. We developed new, biodegradable, and biocompatible nanosized shuttles for Silymarin targeted delivery in colon-cancer cells. The design of these 100 nm sized carrier nanoparticles was based on natural polymers and their biological properties such as cellular uptake potential, cytotoxicity and 3D penetrability were tested using a colon cancer cell line (HT-29) as the in vitro culture model. Comparative scanning electron microscopy (SEM) and atomic force microscopy (AFM) measurements demonstrated that the Silymarin loaded Poly(3-HydroxyButyrate-co-3-HydroxyValerate) (PHBHV) nanocarriers significantly decreased HT-29 cells viability after 6 and 24 h of treatment. Moreover, in vivo-like toxicity studies on multicellular tumor spheroids showed that the Silymarin loaded PHBHV nanocarriers are able to penetrate 3D micro tumors and significantly reduce their size.

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“…In this form, nanoparticles can be biofunctionalized to obtain modern nanocarriers. Using the addition of N-vinylpyrrolidone in the preparation of Ag NPs, it was possible to obtain a carrier for hydrophobic drugs in the aqueous medium, for example indomethacin-a non-steroidal anti-inflammatory drug with high drug loading efficiency of up to 95% [80]. Reznickova et al compared the use of polyethylene glycol modified with various functional groups as a factor modifying AuNPs.…”

Section: Surface Functionalizationmentioning

confidence: 99%

Methods for Reducing the Toxicity of Metal and Metal Oxide NPs as Biomedicine

et al. 2020

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The rapid development of medicine has forced equally rapid progress in the field of pharmaceuticals. In connection with the expensive and time-consuming process of finding new drugs, great emphasis is put on the design and use of metal and metal oxides nanoparticles in nanomedicine. The main focus is on comprehensive presentation of both physicochemical properties and the possibilities of using, in particular, silver (Ag) and gold (Au) nanoparticles, as well as zinc oxide (ZnO) and titanium oxide (TiO2) nanoparticles as drug carriers and in the treatment of cancer. An important element of this subject is the possibility of occurrence of toxic effects of these nanoparticles. For this reason, possible mechanisms of toxic actions are presented, as well as methods used to reduce their toxicity to ensure the safety of drug carriers based on these nanostructures.

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Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: In vitro cytotoxicity and in vivo acute toxicity study

Cited by 43 publications

References 32 publications

Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

Therapeutic activity of sour orange albedo extract and abundant flavanones loaded silica nanoparticles against acrylamide-induced hepatotoxicity

Poly(HydroxyButyrate-co-HydroxyValerate) (PHBHV) Nanocarriers for Silymarin Release as Adjuvant Therapy in Colo-rectal Cancer

Methods for Reducing the Toxicity of Metal and Metal Oxide NPs as Biomedicine

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