Amphiphilic photosensitive dextran-g-poly(o-nitrobenzyl acrylate) glycopolymers

Soliman, Soliman Mehawed Abdellatif; Colombeau, Ludovic; Nouvel, Cécile; Babin, Jérôme; Six, Jean‐Luc

doi:10.1016/j.carbpol.2015.09.061

Cited by 26 publications

(14 citation statements)

References 65 publications

(3 reference statements)

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“…Photosensitive properties of both PNBA [37] and dextran-g-PNBA glycopolymers [38] were already reported by some of us. We also proved that dextran part in such glycopolymers does not prevent, but delays the PNBA photolysis.…”

Section: 4) Light Irradiation Of Pnba-based Nanoparticlessupporting

confidence: 56%

“…Amphiphilic alkynated dextran was derived from dextran. [38] The yield of substitution () of such alkynated dextran was estimated equal to 15% (15 pending alkynyl groups per 100 glucopyranosic units), and its surface tension property was checked (Figure S1). Azido-…”

Section: 1) Materialsmentioning

confidence: 99%

“…[32][33][34][35][36] Very recently, some of us have reported the first controlled polymerization of o-nitrobenzyl acrylate (NBA), [37] then the synthesis of amphiphilic grafted photosensitive glycopolymers called Dex-g-PNBA, composed on dextran (Dex) as hydrophilic backbone and poly(o-nitrobenzyl acrylate) (PNBA) as photo-responsive grafts. [38] To the best of our knowledge, the formulation of nano-objects from polysaccharide/PNBA copolymers has never been reported. Indeed, only two papers are dealing with the light-disruption of nanoobjects based on diblock copolymers containing one PNBA block and one poly(2-ethyl-2oxazoline) [39] or polydimethylacrylamide [40] block.…”

Section: ) Introductionmentioning

confidence: 99%

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Light-sensitive dextran-covered PNBA nanoparticles as triggered drug delivery systems: Formulation, characteristics and cytotoxicity

Founi

Soliman

Vanderesse

et al. 2018

Journal of Colloid and Interface Science

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Section: 4) Light Irradiation Of Pnba-based Nanoparticlessupporting

confidence: 56%

Section: 1) Materialsmentioning

confidence: 99%

Section: ) Introductionmentioning

confidence: 99%

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Light-sensitive dextran-covered PNBA nanoparticles as triggered drug delivery systems: Formulation, characteristics and cytotoxicity

Founi

Soliman

Vanderesse

et al. 2018

Journal of Colloid and Interface Science

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“…The photocleavage process of NB ‐g‐ PHPA can be easily followed on UV–Vis absorption spectra, where o ‐nitrobenzyl and o ‐nitrosobenzaldehyde present two different bands . UV–Vis absorbance spectra of NB ‐g‐ PHPA‐3 aqueous solution were measured before and after different irradiation times (Supporting Information Fig.…”

Section: Resultsmentioning

confidence: 99%

Thermosensitive and photocleavable polyaspartamide derivatives for drug delivery

Jiang

Zhuo

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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The development of novel thermo‐ and photo‐dual‐responsive biodegradable polymeric micelles based on amphiphilic polyaspartamide derivatives (NB‐g‐PHPA‐g‐mPEG) for anticancer drug delivery is reported. The obtained polymers containing hydrophobic photocleavable o‐nitrobenzyl groups exhibit thermo‐ and photosensitivity. The micelles and paclitaxel‐loaded micelles based on the thermo‐ and photo‐dual‐sensitive polymers were prepared by a quick heating method without using toxic organic solvent. The paclitaxel release from the drug‐loaded micelles can be triggered under photoirradiation. Enhancement of the anticancer activity against HeLa cells was observed for paclitaxel‐loaded NB‐g‐PHPA‐g‐mPEG micelles after light irradiation, while the empty NB‐g‐PHPA‐g‐mPEG micelles with or without irradiation did not show any toxicity. Therefore, the thermo‐ and photo‐dual‐responsive NB‐g‐PHPA‐g‐mPEG micelles have a promising future applied as a light controlled drug delivery system for anticancer drugs. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 2855–2863

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“…Wang et al synthesized a dual‐stimuli‐sensitive amphiphilic block copolymer, poly(N‐isopropylacrylamide)‐block‐poly‐(2‐nitrobenzyl methacrylate) (PNIPAM‐b‐PNBM) with a photosensitive PNBM segment and a temperature‐sensitive PNIPAM segment . In spite of many different strategies for the construction of photoresponsive polymers with o ‐NB esters are developed, there have been limited reports to deal with the biocompatible and biodegradable polymers, especially poly(carbonate)s with pendent o ‐NB group applied to drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Photoresponsive biodegradable poly(carbonate)s with pendento‐nitrobenzyl ester

Shen

Xia

Qin

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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Photoresponsive amphiphilic diblock poly(carbonate)s mPEG 113 -b-PMNC n with pendent o-nitrobenzyl ester group were synthesized through ring-opening polymerization (ROP) using 1,8-diazabi-cyclo[5.4.0]undec-7-ene (DBU) as catalyst and monomethoxy poly(ethylene glycol) (mPEG) as macroinitiator. In aqueous solution, the copolymers can self-assemble to spherical micelles with a PC core and a PEG shell. The critical micelle concentration (CMC), size, and morphology of the micelles were demonstrated by means of fluorescence spectroscopy, transmission electron microscopes (TEM), and dynamic light scattering (DLS). Under UV light irradiation, the amphiphilic copolymer micelles disassembled because of the photocleavage of o-NB ester, and the light-controlled release behaviors of payload Nile red were further proved. This study provides a convenient way to construct smart poly(carbonate)s nanocarriers for controlled drug release.

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Amphiphilic photosensitive dextran-g-poly(o-nitrobenzyl acrylate) glycopolymers

Cited by 26 publications

References 65 publications

Light-sensitive dextran-covered PNBA nanoparticles as triggered drug delivery systems: Formulation, characteristics and cytotoxicity

Light-sensitive dextran-covered PNBA nanoparticles as triggered drug delivery systems: Formulation, characteristics and cytotoxicity

Thermosensitive and photocleavable polyaspartamide derivatives for drug delivery

Photoresponsive biodegradable poly(carbonate)s with pendento‐nitrobenzyl ester

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