Amphiphilic Peptide Self-Assembly: Expansion to Hybrid Materials

Mikhalevich, Viktoria; Craciun, Ioana; Kyropoulou, Myrto; Palivan, Cornelia G.

doi:10.1021/acs.biomac.7b00764

Cited by 74 publications

(48 citation statements)

References 79 publications

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“…Self-assembled nanoparticles are suitable for encapsulation of hydrophobic, hydrophilic and amphiphilic drugs [7][8][9]. Nowadays, a wide variety of amphiphilic copolymers of different structure and composition have been described and discussed [4,10,11]. Poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO), polysaccharides (heparin, chitosan, alginate, etc.…”

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Amphiphilic Block-Copolymers Based on Synthetic Glycopolymer and Poly(Amino Acid) as Potential Drug Delivery Systems

et al. 2020

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In this work, a method to prepare hybrid amphiphilic block copolymers consisting of biocompatible synthetic glycopolymer with non-degradable backbone and biodegradable poly(amino acid) (PAA) was developed. The glycopolymer, poly(2-deoxy-2-methacrylamido-D-glucose) (PMAG), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Two methods for modifying the terminal dithiobenzoate-group of PMAG was investigated to obtain the macroinitiator bearing a primary aliphatic amino group, which is required for ring-opening polymerization of N-carboxyanhydrides of hydrophobic α-amino acids. The synthesized amphiphilic block copolymers were carefully analyzed using a set of different physico-chemical methods to establish their composition and molecular weight. The developed amphiphilic copolymers tended to self-assemble in nanoparticles of different morphology that depended on the nature of the hydrophobic amino acid present in the copolymer. The hydrodynamic diameter, morphology, and cytotoxicity of polymer particles based on PMAG-b-PAA were evaluated using dynamic light scattering (DLS) and transmission electron microscopy (TEM), as well as CellTiter-Blue (CTB) assay, respectively. The redox-responsive properties of nanoparticles were evaluated in the presence of glutathione taken at different concentrations. Moreover, the encapsulation of paclitaxel into PMAG-b-PAA particles and their cytotoxicity on human lung carcinoma cells (A549) and human breast adenocarcinoma cells (MCF-7) were studied.

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Section: Introductionmentioning

confidence: 99%

Bio-Inspired Amphiphilic Block-Copolymers Based on Synthetic Glycopolymer and Poly(Amino Acid) as Potential Drug Delivery Systems

et al. 2020

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“…[94][95][96] In this section of the review, we will focus on tyrosine-rich peptide-based hybrid systems that can utilize the redox activity and π-π interactions of tyrosine to synthesize functional materials for catalysis and energy applications. To enrich the applications of peptide materials and promote synergism between inorganic and peptide systems, several hybrid materials have been developed.…”

Section: Tyrosine-rich Peptide-based Hybrid Functional Materialsmentioning

confidence: 99%

Tyrosine‐Rich Peptides as a Platform for Assembly and Material Synthesis

et al. 2018

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The self‐assembly of biomolecules can provide a new approach for the design of functional systems with a diverse range of hierarchical nanoarchitectures and atomically defined structures. In this regard, peptides, particularly short peptides, are attractive building blocks because of their ease of establishing structure–property relationships, their productive synthesis, and the possibility of their hybridization with other motifs. Several assembling peptides, such as ionic‐complementary peptides, cyclic peptides, peptide amphiphiles, the Fmoc‐peptide, and aromatic dipeptides, are widely studied. Recently, studies on material synthesis and the application of tyrosine‐rich short peptide‐based systems have demonstrated that tyrosine units serve as not only excellent assembly motifs but also multifunctional templates. Tyrosine has a phenolic functional group that contributes to π–π interactions for conformation control and efficient charge transport by proton‐coupled electron‐transfer reactions in natural systems. Here, the critical roles of the tyrosine motif with respect to its electrochemical, chemical, and structural properties are discussed and recent discoveries and advances made in tyrosine‐rich short peptide systems from self‐assembled structures to peptide/inorganic hybrid materials are highlighted. A brief account of the opportunities in design optimization and the applications of tyrosine peptide‐based biomimetic materials is included.

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“…[36][37][38][39][40] Amphipathic peptides are emerging as suitable candidates for fabricating well-ordered nanostructures. [41][42][43][44][45][46][47] To take advantage of the vector properties offered by peptides and at the same time start closing the gap in cargo size between ASOs and entire genes, we intended to establish a purely peptidic, self-assembling delivery system that lends itself to the incorporation of single-and double-stranded DNA segments that are larger than the average ASO. Here, we report a novel amphiphilic peptide henceforth called (HR)3gT that is designed to self-assemble into multi-compartment micellar nanoparticles (MCM-NPs).…”

Section: Introductionmentioning

confidence: 99%