Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-responsive anti-cancer agent

Li, Ning; Li, Na; Yi, Qiangying; Luo, Kui; Guo, Chuanbin; Pan, Dayi; Gu, Zhongwei

doi:10.1016/j.biomaterials.2014.07.059

Cited by 191 publications

(143 citation statements)

References 60 publications

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“…Fluorescent and cell studies revealed stable and effective cancer therapy compared with free doxorubicin anticancer drugs. Moreover, this study showed the decreased toxicities from doxorubicin anticancer drug as well as nondetectable side effects [120]. In addition to that, peptide self-assembled multifunctional nanostructures with dual-functional liposomes have also been developed for targeted drug delivery in cancer therapy.…”

Section: Anticancer Drug Deliverymentioning

confidence: 74%

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan

Shen

et al. 2017

Journal of Nanomaterials

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Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

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Section: Anticancer Drug Deliverymentioning

confidence: 74%

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan

Shen

et al. 2017

Journal of Nanomaterials

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“…After that, these signals showed a gradual increase in tumors and kidneys and a decrease in livers, demonstrating clearance of DOX by the liver during blood circulation. 37 It was interesting to know that, the strongest fluorescent signal in tumor sites was found in the DOX/Z-NCs group at 7 h. Thus, one might argue the potential therapeutic effect associated with the targeting ligand FA. Considering the clinical practice, where multiple injections are favored for tumor treatment, comprehensive investigations into tumor growth inhibition and acute systemic toxicity caused by accumulation of the therapeutic agents within the effective time window are of great importance.…”

Section: Biodistribution Studymentioning

confidence: 97%

Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy

Yi¹,

Ma²,

Kang³

et al. 2018

IJN

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Introduction Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy. Materials and methods Functionalized hyaluronan is utilized to build up the NC shells, in which bioreduction cleavable sites, targeting ligand folic acid (FA), and zwitterionic tentacles are integrated. Results The hollow NCs obtained (~50 nm in diameter) showed well-defined spherical shell structures with a shell thickness of ~8 nm. These specially designed NCs (doxorubicin [DOX]/FA-Z-NCs) with high drug encapsulation content exhibited good biocompatibility in vitro and fast intracellular drug release behavior mediated by intracellular glutathione. Conclusion Cellular uptake tests demonstrated rapid uptake of these functionalized NCs and effective escape from endosomes. Antitumor efficacy of the DOX/FA-Z-NCs was confirmed by the significant tumor growth inhibition effect as well as greatly reduced side effects, in contrast with those of the free drug DOX hydrochloride.

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“…[76] In addition to a number of other linear PHPMA conjugates, [77][78][79] the GFLG peptide linker has also been used to develop micellar- [80,81] and dendrimer-based carriers that are able to release their payload in the lysosomes. [82][83][84][85] The GFLG peptide linker has not only been used to trigger cathepsin B-mediated drug release from various polymerbased systems but has also been exploited to prepare polymersomes that disintegrate upon exposure to this enzyme. This was accomplished by Lee et al who used this peptide to connect PEG and poly(d,l-lactide) to form diblock copolymers, which could self-assemble to form polymersomes with an average size 124 nm.…”

Section: Endosomes/ Lysosomesmentioning

confidence: 99%

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

Battistella

Klok

2017

Macromolecular Bioscience

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Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer‐based nanocarriers allow to increase plasma half‐life and drug bioavailability and can also be guided toward tumors using passive and active targeting strategies. Since many chemotherapeutics act on targets that are located in well‐defined subcellular compartments, other important factors that contribute to an efficient therapy include cellular internalization and subsequent intracellular trafficking of the polymer nanomedicines and/or its payload to the appropriate organelle in the cytoplasm. This article provides an overview of the different approaches that have been developed to control intracellular delivery of polymer nanomedicines and discusses the different techniques that can be used to monitor these processes.

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Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-responsive anti-cancer agent

Cited by 191 publications

References 60 publications

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy

Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines

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