Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging

Li, Xiaojie; Qian, Yinfeng; Liu, Tao; Hu, Xianglong; Zhang, Guoying; You, Ye‐Zi; Liu, Shiyong

doi:10.1016/j.biomaterials.2011.05.049

Cited by 257 publications

(174 citation statements)

References 49 publications

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“…MCF-7 cells and MCF-7/ADR cells were transplanted into female BALB/c nude mice by subcutaneous injection of 1×10 7 cells in the right rare flanks of the mice, respectively. When the tumor volume reached 50-100 mm 3 , administration was started and the day was considered as day 0. At day 0, the mice were randomly divided into five groups (seven mice per group).…”

Section: Antitumor Efficacy Of Dox-incorporated Micellesmentioning

confidence: 99%

“…1 Recently, multifunctional nanocarriers have been emerging as a promising approach to overcome the biologic complexity and heterogeneity during cancer chemotherapy. [2][3][4][5] The most distinguishing benefit of multifunctional nanocarriers is that they can be engineered to achieve targeted delivery of multiple therapeutic agents for multimodal chemotherapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

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Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells

Hong

Shi

Qiao

et al. 2017

IJN

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Even though a tremendous number of multifunctional nanocarriers have been developed to tackle heterogeneous cancer cells, little attention has been paid to elucidate how to rationally design a multifunctional nanocarrier. In this study, three individual functions (active targeting, stimuli-triggered release and endo-lysosomal escape) were evaluated in doxorubicin (DOX)-sensitive MCF-7 cells and DOX-resistant MCF-7/ADR cells by constructing four kinds of micelles with active-targeting (AT-M), passive targeting, pH-triggered release ( pH T-M) and endo-lysosomal escape ( endo E-M) function, respectively. AT-M demonstrated the strongest cytotoxicity against MCF-7 cells and the highest cellular uptake of DOX due to the folate-mediated endocytosis. However, AT-M failed to exhibit the best efficacy against MCF-7/ADR cells, while endo E-M exhibited the strongest cytotoxicity against MCF-7/ADR cells and the highest cellular uptake of DOX due to the lowest elimination of DOX from the cells. This was attributed to the carrier-facilitated endo-lysosomal escape of DOX, which avoided exocytosis by lysosome secretion, resulting in an effective accumulation of DOX in the cytoplasm. The enhanced elimination of DOX from the MCF-7/ADR cells also accounted for the remarkable decrease in cytotoxicity against the cells of AT-M. Three micelles were further evaluated with MCF-7 cells and MCF-7/ADR-resistant cells xenografted mice model. In accordance with the in vitro results, AT-M and endo E-M demonstrated the strongest inhibition on the MCF-7 and MCF-7/ADR xenografted tumor, respectively. Active targeting and active targeting in combination with endo-lysosomal escape have been demonstrated to be the primary function for a nanocarrier against doxorubicin-sensitive and doxorubicin-resistant MCF-7 cells, respectively. These results indicate that the rational design of multifunctional nanocarriers for cancer therapy needs to consider the heterogeneous cancer cells and the primary function needs to be integrated to achieve effective payload delivery.

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Section: Antitumor Efficacy Of Dox-incorporated Micellesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells

Hong

Shi

Qiao

et al. 2017

IJN

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“…While a unimolecular micelle consists of simple, usually hydrophilic polymeric chains anchored to a dendritic core [12], the CMS nanocarrier is a unimolecular structure that has a branched core-unit with amphiphilic polymeric chains attached to it, which at least consist of one hydrophilic and one hydrophobic block (see Figure 1). Frequently used core structures are the polyester Boltorn ® H40 [13,14], poly (ethyleneimine) (PEI) and the highly hydrophilic hyperbranched polyglycerolamine (hPG-NH2) [15,16]. Initially designed as a unimolecular liposome, the CMS nanotransporter has been reported by our group for the transport of both hydrophilic and lipophilic guest molecules [11,15].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

et al. 2017

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Abstract:We here present the synthesis and characterization of a set of biodegradable core-multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12,15,18,19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.

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“…For example, some methods of chemotherapeutic drug delivery involve shielding cytotoxic drugs so they can be introduced systemically into the blood stream, and designing the shielding to undergo localized and selective release only around cancerous cells based on specific indicators such as pH or overexpression of particular proteins. [23] Localization of drug delivery can also be achieved simply by incorporating the drug delivery system into a tissue engineering material, as discussed here. The tissue engineering material must be implanted at the specific injury or disease site, providing a base for highly localized drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials

Bruggeman

Williams

Nisbet

2017

Adv Healthcare Materials

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Tissue engineering scaffolds are designed to mimic physical, chemical, and biological features of the extracellular matrix, thereby providing a constant support that is crucial to improved regenerative medicine outcomes. Beyond mechanical and structural support, the next generation of these materials must also consider the more dynamic presentation and delivery of drugs or growth factors to guide new and regenerating tissue development. These two aspects are explored expansively separately, but they must interact synergistically to achieve optimal regeneration. This review explores common tissue engineering materials types, electrospun polymers and hydrogels, and strategies used for incorporating drug delivery systems into these scaffolds.

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Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging

Cited by 257 publications

References 49 publications

Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells

Rational design of multifunctional micelles against doxorubicin-sensitive and doxorubicin-resistant MCF-7 human breast cancer cells

Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials

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