Amphiphilic mPEG-block-poly (profen amide-co-esters) copolymers: One pot biocatalytic synthesis, self-assembly in water and drug release

Qian, Xiaofei; Wu, Qi; Xu, Fangli; Lin, Xianfu

doi:10.1016/j.polymer.2011.10.003

Cited by 17 publications

(9 citation statements)

References 29 publications

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“…To combine the advantages of polymer‐drug conjugates and polymer micelles carriers of drugs,30–32 we focused on the macromolecular prodrugs micelles, which can provide a much more effective way to control the level of drug‐loading and the rate of drug release than the general polymer micelles. An amphiphilic macromolecular prodrug containing R ‐mexiletine was designed, and its preparation starting from ( R )‐MAPP, divinyl diesters, and mPEG ( M w = 1000) is shown in Scheme .…”

Section: Resultsmentioning

confidence: 99%

Real‐time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Yokoyama

Otani

Hashidate

et al. 2011

Cancer

105

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BACKGROUND: Recently, a highly sensitive fluorescent imaging technique was developed for the real-time identification of hepatic tumors. The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer. METHODS: Forty-nine consecutive patients with pancreatic cancer who underwent surgical intervention were examined. Preoperative clinical images had not revealed any hepatic metastases. On the day before surgery, indocyanine green was injected intravenously. During the operation, the liver was observed with a near-infrared camera system, and abnormal fluorescent foci were examined by frozen-section histology. The patients with hepatic micrometastases were judged to have unresectable disease and underwent only palliative surgery followed by systemic chemotherapy using gemcitabine. RESULTS: Abnormal hepatic fluorescence at least 1.5 mm in greatest dimension without any apparent tumor was observed in 13 patients. Among them, histologic examination confirmed micrometastases in 8 of 49 patients (16%). All patients with hepatic micrometastases had clinical T3 or T4 disease and high serum CA19-9 levels (P ¼ .042). On follow-up computed tomography images that were obtained within 6 months after surgery, the patients with hepatic micrometastases manifested hepatic overt metastases (7 of 8 patients; 88%) more frequently than the patients without hepatic micrometastases (4 of 41 patients; 10%; P < .001). Regardless of histologic confirmation, the positive predictive value of abnormal fluorescence for the manifestation of hepatic relapse within 6 months was 77% (10 of 13 patients), and the negative predictive value was 97% (35 of 36 patients). CONCLUSIONS: Indocyanine green-fluorescent imaging can detect hepatic micrometastases of pancreatic cancer during surgery. The hepatic micrometastases seem to have an adverse clinical impact identical to that of evident distant metastases. Cancer 2012;118:2813-

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Section: Resultsmentioning

confidence: 99%

Real‐time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Yokoyama

Otani

Hashidate

et al. 2011

Cancer

105

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“…[ 177 ] Using also CALB, they prepared amphiphilic diblock methoxy PEG‐ b ‐poly(amide‐ co ‐esters) copolymers containing different profens such as ketoprofen, naproxen, and ibuprofen. [ 178 ]…”

Section: Polyesters Synthesized By Enzymatic Polymerizationmentioning

confidence: 99%

Enzymatic Synthesis of Polyesters and Their Bioapplications: Recent Advances and Perspectives

Hevilla

Sonseca

Echeverría

et al. 2021

Macromolecular Bioscience

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This article reviews the most important advances in the enzymatic synthesis of polyesters. In first place, the different processes of polyester enzymatic synthesis, i.e., polycondensation, ring opening, and chemoenzymatic polymerizations, and the key parameters affecting these reactions, such as enzyme, concentration, solvent, or temperature, are analyzed. Then, the latest articles on the preparation of polyesters either by direct synthesis or via modification are commented. Finally, the main bioapplications of enzymatically obtained polyesters, i.e., antimicrobial, drug delivery, or tissue engineering, are described. It is intended to point out the great advantages that enzymatic polymerization present to obtain polymers and the disadvantages found to develop applied materials.

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“…A few years earlier the same authors used the same principle to synthesize amphiphilic mPEG-block-poly(profenamide-co-ester) copolymers that self-assembled in water and could be used for drug release [ 72 ]. As a follow up the same laboratory used triethanolamine and different dimethyl esters of linear dicarboxylic acids to synthesize hyperbranched polymers.…”

Section: Reviewmentioning

confidence: 99%

Dicarboxylic esters: Useful tools for the biocatalyzed synthesis of hybrid compounds and polymers

Bassanini¹,

Hult²,

Riva³

2015

Beilstein J. Org. Chem.

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Amphiphilic mPEG-block-poly (profen amide-co-esters) copolymers: One pot biocatalytic synthesis, self-assembly in water and drug release

Cited by 17 publications

References 29 publications

Real‐time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Real‐time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Enzymatic Synthesis of Polyesters and Their Bioapplications: Recent Advances and Perspectives

Dicarboxylic esters: Useful tools for the biocatalyzed synthesis of hybrid compounds and polymers

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