Real‐time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Yokoyama, Naoyuki; Otani, Tetsuya; Hashidate, Hideki; Maeda, Chiyo; Katada, Tomohiro; Sudo, Natsuru; Manabe, Shoichi; Ikeno, Yoshinobu; Toyoda, Akira; Katayanagi, Norio

doi:10.1002/cncr.26594

Cited by 105 publications

(73 citation statements)

References 43 publications

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“…At the same time, Gotoh et al reported the results of ICG fluorescence imaging of 14 HCCs (10 cases) that included 4 nodules first discovered by this technique [2]. Yokoyama et al recently added a report on the possibility of applying ICG fluorescence imaging to the intraoperative diagnosis of micrometastases of pancreatic cancer [20].…”

Section: Discovery Of Fluorescence Imaging Of Liver Cancermentioning

confidence: 99%

Clinical Application of Fluorescence Imaging of Liver Cancer Using Indocyanine Green

Kokudo

Ishizawa

2012

Liver Cancer

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Recently, fluorescence imaging using indocyanine green (ICG) has been applied to hepatobiliary surgery, not only to visualize the bile ducts, but also to identify liver cancer during surgery. In this technique, ICG is administered intravenously at a dose of 0.5 mg/kg body weight for routine liver function testing before surgery. Intraoperatively, liver cancer can be readily identified by fluorescence imaging on the liver surface before resection and on the cut surface of the resected specimen. This is achieved by visualizing fluorescence from the area of impaired bile excretion in hepatocellular cancer tissue and in the liver parenchyma surrounding metastatic liver cancers. Liver cancer navigation surgery, first developed in Japan, is also possible, and it represents one of the few fluorescence imaging techniques for cancer that have reached the stage of clinical application; with further developments in basic research, fluorescence imaging is expected to become an indispensable technique for the diagnosis and treatment of liver cancer.

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Section: Discovery Of Fluorescence Imaging Of Liver Cancermentioning

confidence: 99%

Clinical Application of Fluorescence Imaging of Liver Cancer Using Indocyanine Green

Kokudo

Ishizawa

2012

Liver Cancer

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“…[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] A total of 718 cases were globally analyzed as study group. No side effects of ICG were reported in any articles.…”

Section: Resultsmentioning

confidence: 99%

Different ways to manage indocyanine green fluorescence to different purposes in liver surgery: A systematic review

et al. 2018

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Journal of Peritoneum (and other serosal surfaces) 2018; volume 3:96 AbstractFluorescent properties of indocyanine green (ICG) for hepatic tumor identification and features have been recently studied. The aim is to review the published data on the use of ICG enhanced fluorescence surgery during liver resection. A systematic search of literature was performed using MEDLINE, EMBASE, Cochrane and Web of Science libraries. For all eligible studies, the following data were extracted: study design, number of cases, management of indocyanine green (dose, time and method of administration), type of surgery, outcome variables, false positive and accuracy value, if reported. For statistical analysis, it was considered significant P<0.05, when published. 19 articles were fully analyzed and data were extracted. A total of 718 cases were globally analyzed as study group. No side effects of ICG were reported in any articles. 12 prospective observational, 1 randomized and 2 case-control studies were found. Three case reports and one experimental on animal model were also included. Detection of superficial lesions, segmental staining, biliary anatomy investigation (biliary leakage detection, biliary tree anatomy) were the main clinical application of fluorescence liver guided surgery. The overall quality of the data currently available is limited but the role of fluorescence guided liver surgery seems promising.

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“…Intravenously administered ICG has also been used in NIR endoscopy systems to successfully differentiate superficial gastric tumors from invasive cancers (13). ICG has been shown to localize to both hepatocellular carcinoma and intrahepatic metastases 24-72 hours after injection with high target-to-background ratios (2,3,6). The mechanism by which ICG localizes to intrahepatic metastases has recently begun to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Ill (2)(3)(4)(5)(6). The intraoperative imaging of ICG for the detection of intrahepatic malignancy has been demonstrated (2,3,6).…”

Section: Molecular Imaging: Interventional Optical Molecular Imaging mentioning

confidence: 99%

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Interventional Optical Molecular Imaging Guidance during Percutaneous Biopsy

Sheth¹,

Heidari²,

Wood³

et al. 2014

Radiology

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Purpose:To investigate indocyanine green (ICG) as a molecular beacon for malignant lesions within the liver and evaluate the ability of a developed handheld imaging system to allow measurement of ICG fluorescence within focal hepatic lesions with high target-to-background ratios in a mouse model. Materials and Methods:All animal experiments were approved by the institutional animal care committee. A handheld optical molecular imaging device was constructed to pass through the introducer needle of a standard percutaneous biopsy kit. An ex vivo phantom system was constructed to quantify tissue attenuation properties of ICG in liver parenchyma. Subsequently, intrahepatic colorectal cancer metastases were generated in nude mice, and epifluorescence imaging of ICG, as well as histologic analysis of the explanted livers, was performed at 3 weeks after implantation (n = 6). Epifluorescence imaging with the handheld imaging device was then performed on intrahepatic colorectal metastases after the administration of ICG (n = 15) at 3, 6, and 24 hours after injection. Target-to-background ratios were calculated for each time point. Subsequently, a core biopsy of intrahepatic colorectal metastases was performed by using a standard clinical 18-gauge biopsy needle. Results:There was avid localization of ICG to the focal lesions at all time points. Similarly, fluorescence within the tumors was greater than that within normal liver, as detected with the handheld imaging system (mean target-to-background ratio 6 standard deviation, 3.9 6 0.2 at 24 hours). A core biopsy of tumor and normal adjacent liver by using a standard biopsy needle demonstrated a sharp margin of fluorescence intensity at the tumor-liver interface. Conclusion:The custom-designed molecular imaging device, in combination with ICG, readily allowed differentiation between normal and malignant tissue in a murine model of intrahepatic colorectal metastasis.q RSNA, 2014

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Real‐time detection of hepatic micrometastases from pancreatic cancer by intraoperative fluorescence imaging

Cited by 105 publications

References 43 publications

Clinical Application of Fluorescence Imaging of Liver Cancer Using Indocyanine Green

Clinical Application of Fluorescence Imaging of Liver Cancer Using Indocyanine Green

Different ways to manage indocyanine green fluorescence to different purposes in liver surgery: A systematic review

Interventional Optical Molecular Imaging Guidance during Percutaneous Biopsy

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