Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs

Mayol, Laura; Biondi, Marco; Russo, L; Malle, Birgitte M.; Schwach-Abdellaoui, Khadija; Borzacchiello, Assunta

doi:10.1016/j.carbpol.2013.11.003

Cited by 71 publications

(44 citation statements)

References 24 publications

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“…Indeed, the plot of the percentage of released DS as a function of the square root of time is basically linear for up to 5 hours (inset of figure 5). This shows that, in this time frame, drug diffusion does control the release process [40]. Afterwards, a final phase of rapid release occurs, suggesting that, at this stage of the process, a different release mechanism prevails other than ion exchange, presumably related to the partial absorption of molecules of DS inside the SMNZ that can be released only when the superficially exposed DS has been exchanged.…”

Section: In Vitro Drug Loading and Release Testsmentioning

confidence: 95%

Surface modified natural zeolite as a carrier for sustained diclofenac release: A preliminary feasibility study

Gennaro

Catalanotti

Cappelletti

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: In Vitro Drug Loading and Release Testsmentioning

confidence: 95%

Surface modified natural zeolite as a carrier for sustained diclofenac release: A preliminary feasibility study

Gennaro

Catalanotti

Cappelletti

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Hydrophobically modified HA exhibits amphiphilic characteristics in solution . The polymer backbone is hydrophilic, preferring to be associated with polar solvents through ion hydration or hydrogen bonding, while the functional groups are hydrophobic preferring to be associated with nonpolar solvents.…”

Section: Resultsmentioning

confidence: 99%

Molar Mass Analysis of Hydrophobically Modified Hyaluronic Acid by SEC‐MALLS: Facing the Challenges of Amphiphilic Biomacromolecules

Botha

Kuntz

Moire

et al. 2018

Macro Chemistry & Physics

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A size exclusion chromatography–multiangle laser light scattering (SEC‐MALLS) method is developed for determining the molar masses of amphiphilic hyaluronan (HA), consisting of a hydrophilic polymer backbone modified to varying extents with hydrophobic, polymerizable acrylate groups. The polymers are prepared via the base‐catalyzed esterification of HA with acrylic anhydride. Various parameters are investigated including mobile phase composition, temperature, pH, salt type, and concentration in order to find the most suitable conditions for completely dissolving the modified polymers irrespective of the degree of substitution (DS), and for suppressing secondary polymer interactions. The hydrolytic and the thermal stability of the different materials at various experimental conditions are also extensively investigated. HAs with DS varying from 0 to 3.4 are subsequently analyzed at the optimized experimental conditions for the mobile phase being DMSO/H2O 60/40(v/v) with 0.05 M LiBr and an operating temperature of 40 °C. The refractive index increments (dn/dc) of the HAs are determined and the results show a dependence of dn/dc on DS.

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“…Similar differences can also be found among novel systems proposed as candidates for viscosupplementation. 40,[42][43][44][45] Tests performed on blends with different gel fractions have shown that an acceptable structural recovery after continuous shear application (more than 80-90 %) is attained when the gel fraction is lower than 50 %. Thus, the 6/4 CMCAp/CMCAg blend has been provisionally selected for the final investigation addressed to individuate the most suitable total polymer concentration, apt to compensate the loss in mechanical properties occurring during processing and sterilization.…”

Section: F I G 4 -Viscoelastic Responses Of 25 % Cmcap and 25 % Cmentioning

confidence: 99%

Rheological Studies Dedicated to the Development of a Novel Injectable Polymeric Blend for Viscosupplementation Treatment

Lapasin

Segatti

Mercuri

et al. 2016

Chem. Biochem. Eng. Q.

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Viscosupplementation is an intra-articular symptomatic treatment of mild osteoarthritis. The treatment involves the injection of high-molecular-weight hyaluronan (HA), and especially of cross-linked HA to restore the lubricating and cushioning properties of the synovial fluid.This work involves the development of a novel viscosupplementation fluid based on amidated carboxymethylcellulose and obtained by blending the soluble polymer with its crosslinked derivative. Rheological analyses carried out under both oscillatory and continuous shear provided a rationale to assess the viscosupplement formulation and the production process. The hydrogel fraction content and the total polymer concentration can be properly selected in order to ensure an optimal combination of flowability and viscoelastic properties.

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Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs

Cited by 71 publications

References 24 publications

Surface modified natural zeolite as a carrier for sustained diclofenac release: A preliminary feasibility study

Surface modified natural zeolite as a carrier for sustained diclofenac release: A preliminary feasibility study

Molar Mass Analysis of Hydrophobically Modified Hyaluronic Acid by SEC‐MALLS: Facing the Challenges of Amphiphilic Biomacromolecules

Rheological Studies Dedicated to the Development of a Novel Injectable Polymeric Blend for Viscosupplementation Treatment

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