Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics

Salim, Malinda; Minamikawa, Hiroyuki; Sugimura, Akihiko; Hashim, Roslan

doi:10.1039/c4md00085d

Cited by 78 publications

(41 citation statements)

References 154 publications

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“…The unique interaction of metal nanoparticles with light opens up unexplored avenues for the development of alternative approaches in bioimaging and diagnostics . In fact, nanomedicine represents one of the most promising research areas for application of plasmonic nanoparticles, related to drug delivery, photothermal therapy, antibacterial surfaces, theranostics, and biosensing …”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Noble Metal Nanoparticles through Seeded Emulsion Polymerization as Highly Stable Plasmonic Systems

Scarabelli

Aberasturi

et al. 2019

Adv Funct Materials

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The implementation of plasmonic nanoparticles in vivo remains hindered by important limitations such as biocompatibility, solubility in biological fluids, and physiological stability. A general and versatile protocol is presented, based on seeded emulsion polymerization, for the controlled encapsulation of gold and silver nanoparticles. This procedure enables the encapsulation of single nanoparticles as well as nanoparticle clusters inside a protecting polymer shell. Specifically, the efficient coating of nanoparticles of both metals is demonstrated, with final dimensions ranging between 50 and 200 nm, i.e., sizes of interest for bio-applications. Such hybrid nanocomposites display extraordinary stability in high ionic strength and oxidizing environments, along with high cellular uptake, and low cytotoxicity. Overall, the prepared nanostructures are promising candidates for plasmonic applications under biologically relevant conditions.

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Section: Introductionmentioning

confidence: 99%

Encapsulation of Noble Metal Nanoparticles through Seeded Emulsion Polymerization as Highly Stable Plasmonic Systems

Scarabelli

Aberasturi

et al. 2019

Adv Funct Materials

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“…Surfactant molecules form various aggregates, that is, the aggregate structure changes significantly with the structure of the alkyl chain, concentrations, temperature, and addition of salts or oils. In general, surfactants with branched and double-stranded structures produce LC under various conditions (Kunieda and Shinoda, 1978;Rogers and Winsor, 1967;Salim et al, 2014;Small, 1967;Suzuki et al, 1989;Suzuki and Takei, 1986;Warr et al, 1988). Furthermore, the region of LC and W m decreases with the addition of metal ions.…”

Section: Identification Of the Liquid Crystalline Structurementioning

confidence: 99%

“…The branched structure in alkyl chains changes the phase behavior of surfactant/water/oil ternary systems. Branched surfactants often form liquid crystalline phases (LC) (Kunieda and Shinoda, 1978;Rogers and Winsor, 1967;Salim et al, 2014;Small, 1967;Suzuki et al, 1989;Suzuki and Takei, 1986;Warr et al, 1988). A lamellar LC was found to be formed in lecithin/water systems (Small, 1967).…”

Section: Introductionmentioning

confidence: 99%

Phase Transitions of Branched Fatty‐Acid Calcium Salt/Water Systems

Yamamoto

Kakehashi

Aramaki

et al. 2018

J Surfact & Detergents

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Calcium (Ca) salts of fatty acids are powder materials, which exhibit lubricant, hydrophobic, and bactericidal properties. These physical and biological properties depend on the chemical structure of the alkyl chain of the fatty acids. In this study, the phase behavior of iso‐stearic acid Ca salt/water binary systems was studied, and the effect of the branched structure in the alkyl chain was analyzed. Herein, calcium chloride is added to the iso‐stearic acid aqueous solution. The state of the binary systems changed with the molar ratio (R) of [Ca2+]/[iso‐stearic acid]. Precipitation occurred when R was more than 0.05, whereas the mixture changed from a micelle phase (Wm) to an oil phase (O) through a liquid crystalline phase (LC) when R was less than 0.01. The polarized microscopy images and small‐angle X‐ray scattering profiles showed that the LC is in a lamellar liquid crystalline state. In addition, we evaluated the crystal structure of the precipitated material. These results showed that the iso‐stearic acid Ca salt was in the amorphous state. In contrast, the n‐stearic acid Ca salt formed only the Wm and gel phases. These findings suggest that the branched structure of fatty acids induces loose intermolecular packing of liquid crystalline structures.

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“…The use of amphiphiles as delivery systems is the most explored biomedical application, though, as liposomes and amphiphilic polymers can encapsulate both hydrophobic, hydrophilic, and amphiphilic cargos [130][131][132]. Due to their biocompatibility, biodegradability, and relatively low immunogenicity, liposomes have been used to deliver enzymes, genetic material, drugs, and other small molecules [129]. The enhanced mechanical and chemical stability of polymerosomes, compared to liposomes, make them a versatile class of compounds for delivery of, e.g., drugs and genes.…”

Section: Amphiphiles In Biomedical Applicationsmentioning

confidence: 99%

“…In sufficient concentration they readily undergo self-assembly to form (depending on the hydrophobic/hydrophilic ratio [129,130]) micelles, bilayers or vesicles [131]. If the latter consist primarily of phospholipids, these self-assembled structures are known as liposomes [129,131]. Semisynthetic amphiphiles have been produced through formation or modification of polypeptides, polynucleotides, or polysaccharides [130].…”

Section: Amphiphiles In Biomedical Applicationsmentioning

confidence: 99%

Fucoidan-Mimetic Glycopolymers : Synthesis and Biomedical Applications

Tengdelius¹

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Cover: 3D models of three different fucoidan-mimetic glycopolymers Linköping Studies in Science and Technology Dissertations No. 1743 Printed by LiU-Tryck, Linköping, Sweden, 2016 Till morfar som inspirerade mig att börja och Lina och Theo som inspirerar mig att fortsätta. Mattias Tengdelius Fucoidan-Mimetic Glycopolymers -Synthesis and Biomedical Applications I AbstractThe marine polysaccharide fucoidan has demonstrated several interesting biological properties, for instance being antiviral, anticoagulant, anti-inflammatory, anticancer, and platelet activating. Many of these properties are desirable for various biomedical applications. Yet, there are few reports on fucoidan being used in such applications. The reasons for this are primarily the heterogeneity and low structural reproducibility of fucoidan.This thesis describes the synthesis of polymers with pendant saccharides bearing the key structural features of fucoidan. These glycopolymers were synthesized via different radical polymerization techniques yielding polymers of different chain lengths and dispersity. These glycopolymers showed antiviral and platelet activating properties similar to those of natural fucoidan, thus making them fucoidan-mimetic glycopolymers. However, compared to fucoidan from natural sources, the fucoidan-mimetic glycopolymers had homogeneous and reproducible structures making them suitable for biomedical applications.Further studies demonstrated that platelet activation, caused by these glycopolymers, showed dose-response curves almost identical to fucoidan. The platelet activation was induced via intracellular signaling and caused platelet surface changes similar to those of fucoidan. Fucoidan-mimetic glycopolymers can therefore be used as unique biomolecular tools for studying the molecular and cellular responses of human platelets.Fucoidan-mimetic glycopolymers generally assert their antiviral activity by blocking viral entry to host cells, thus inhibiting spreading of the viral infection but not acting virucidal, i.e. not killing the viruses. Introduction of hydrophobic groups to the polymer's chain ends improved the antiviral properties significantly and is an important step towards yielding glycopolymers with virucidal properties.The fucoidan-mimetic glycopolymers were also applied as capping agents when synthesizing gold nanoparticles. These fucoidan-mimetic glycopolymer coated gold nanoparticles showed improved colloidal stability compared to uncapped gold nanoparticles. Furthermore, the nanoparticles also demonstrated selective cytotoxicity against a human colon cancer cell line over fibroblast cells. III Populärvetenskaplig SammanfattningSedan urminnes tider har människan vänt sig till naturen för att bota sjukdomar och andra krämpor. Genom extrakt från framförallt växter har bland annat feber, inflammationer och olika infektioner behandlats långt innan läkemedelskonsten utvecklades till vad den är idag. Även när den moderna läkemedelsvetenskapen, farmakologin, började utvecklas var det naturen som var den främst...

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Amphiphilic designer nano-carriers for controlled release: from drug delivery to diagnostics

Abstract: Our review highlights lipid liquid crystal nanocarriers, essentially their design considerations and sugar-based materials for specific targeted delivery.

Cited by 78 publications

References 154 publications

Encapsulation of Noble Metal Nanoparticles through Seeded Emulsion Polymerization as Highly Stable Plasmonic Systems

Encapsulation of Noble Metal Nanoparticles through Seeded Emulsion Polymerization as Highly Stable Plasmonic Systems

Phase Transitions of Branched Fatty‐Acid Calcium Salt/Water Systems

Fucoidan-Mimetic Glycopolymers : Synthesis and Biomedical Applications

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