Amphiphilic chitosan–polyaminoxyls loaded with daunorubicin: Synthesis, antioxidant activity, and drug delivery capacity

Sen, V. D.; Балакина, А. А.; Stupina, Tatyana S.; Mumyatova, V. A.; Куликов, А. В.; Тихонов, И. В.; Терентьев, А. А.; Плисс, Е. М.

doi:10.1016/j.ijbiomac.2021.10.170

Cited by 6 publications

(3 citation statements)

References 63 publications

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“…Introducing hydrophobic moieties into chitosan molecules is an attractive approach to forming chitosan‐based micelles 15–20 . These micelle systems are focused on the encapsulation of a single antioxidant 10,16,21–24 . For example, in our previous study, chitosan‐graft‐polylactic acid micelles were fabricated to encapsulate hydrophobic β‐carotene with enhanced water solubility and storage stability 25 .…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17][18][19][20] These micelle systems are focused on the encapsulation of a single antioxidant. 10,16,[21][22][23][24] For example, in our previous study, chitosan-graft-polylactic acid micelles were fabricated to encapsulate hydrophobic β-carotene with enhanced water solubility and storage stability. 25 However, single antioxidant encapsulation still suffers from the drawbacks of low entrapment efficiency, insufficient loading content and limitations of functionality.…”

mentioning

confidence: 99%

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Dual natural antioxidant‐loaded chitosan‐graft‐oleic acid micelles by ultrasound‐assisted self‐assembly: Potential additives for antioxidant active packaging

Han

Wang

2023

Packag Technol Sci

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Natural antioxidants are beneficial additives for active packaging due to their ability to resist oxidative damage. Polymeric micelles are effective in delivering natural antioxidants in aqueous environments. However, individual encapsulation of a single antioxidant may not be sufficient to meet the needs of modern food packaging. A dual natural antioxidant‐loaded micellar system (i.e., vitamin E [VE] and curcumin [Cur]) was developed to achieve combined functionality and high loading concentration. Chitosan‐graft‐oleic acid (CSOA) micelles were employed as carriers to co‐encapsulate VE and Cur through a facile ultrasound‐assisted self‐assembly method. The prepared VE and Cur co‐loaded micelles (CSOA/VE/Cur) exhibited a uniform spherical structure with an average particle size of 210.6 nm and a zeta potential of +29.5 mV. Moreover, the co‐encapsulation of VE and Cur showed a significant enhancement in both entrapment efficiency, loading capacity and stability as compared to the individual encapsulation of either VE or Cur. In addition, the CSOA/VE/Cur micelles showed improved antioxidant activity than free VE/Cur at the same concentrations, as evidenced by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Moreover, the micellar materials were utilized to fabricate regenerated cellulose (RC) films with antioxidant properties, highlighting their potential as additives for antioxidant active packaging.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Dual natural antioxidant‐loaded chitosan‐graft‐oleic acid micelles by ultrasound‐assisted self‐assembly: Potential additives for antioxidant active packaging

Han

Wang

2023

Packag Technol Sci

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“…Quite a broad range of inorganic and organic materials are considered as carriers of drugs, in part, DOX and its derivatives. They are nanotubes [1], apoferritin [2], mesoporous silica nanoparticles [3], nanoparticles of complex composition based on SiO 2 [4], vaterite (CaCO 3 ) [5,6] including dextrane sulphate and poly-L-arginine [6], natural biopolymers (chitosan [7]), synthetic biocompatible polymers and copolymers [8,9], nanoparticles of polypyrrole and poly(2-diethylamino)ethyl methacrylate [10], dextrin nanogels [11], lipoic acid derivative of cyclodextrin [12,13], etc. More details can be found in the reviews [14,15].…”

Section: Introductionmentioning

confidence: 99%

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

et al. 2022

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Nanosized systems of DOX with antitumor activity on the base of micelle-like particles of amphiphilic thermosensitive copolymers of N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM), and N-vinylpyrrolidone and methacrylic acid (MAA) with TEGDM were explored. They were investigated in aqueous solutions by electron absorption spectroscopy, dynamic light scattering and cyclic voltammetry. Experimental data and quantum-chemical modeling indicated the formation of a hydrogen bond between oxygen-containing groups of monomer units of the copolymers and H-atoms of OH and NH2 groups of DOX; the energies and H-bond lengths in the considered structures were calculated. A simulation of TDDFT spectra of DOX and its complexes with the VP and TEGDM units was carried out. Electrochemical studies in PBS have demonstrated that the oxidation of encapsulated DOX appeared to be easier than that of the free one, and its reduction was somewhat more difficult. The cytotoxicity of VP-TEGDM copolymer compositions containing 1, 5 and 15 wt% DOX was studied in vitro on HeLa cells, and the values of IC50 doses were determined at 24 and 72 h of exposure. The copolymer compositions containing 5 and 15 wt% DOX accumulated actively in cell nuclei and did not cause visual changes in cell morphology.

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Endogenous stimuli-responsive drug delivery nanoplatforms for kidney disease therapy

Fang,

Xu,

Wang

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Amphiphilic chitosan–polyaminoxyls loaded with daunorubicin: Synthesis, antioxidant activity, and drug delivery capacity

Cited by 6 publications

References 63 publications

Dual natural antioxidant‐loaded chitosan‐graft‐oleic acid micelles by ultrasound‐assisted self‐assembly: Potential additives for antioxidant active packaging

Dual natural antioxidant‐loaded chitosan‐graft‐oleic acid micelles by ultrasound‐assisted self‐assembly: Potential additives for antioxidant active packaging

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

Endogenous stimuli-responsive drug delivery nanoplatforms for kidney disease therapy

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