Amperometric paper sensor based on Cu nanoparticles for the determination of carbohydrates

Terzi, Fabio; Zanfrognini, Barbara; Ruggeri, Stefano; Dossi, Nicolò; Casagrande, Gabriela Morais; Piccin, Evandro

doi:10.1016/j.snb.2017.01.064

Cited by 29 publications

(16 citation statements)

References 20 publications

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“…In addition, the use of paper-based analytical devices with colorimetric [28,29], mass spectrometry [22] and electrochemical detectors [30][31][32] has successfully generated the creation of powerful tools for applications in different research fields. Among the mentioned detectors, electro-chemistry is quite promising due to its compatibility with microfabrication techniques, adjustable selectivity, low detectability levels and portability, especially when used in combination with battery-powered potentiostats [33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

et al. 2018

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The adulteration of whiskey with analgesics and sedation drugs has been a common practice to prevent hangover the following day and promote loss of consciousness. In both situations, the portable and low cost detection platforms are of paramount importance for forensic investigations. This report describes the use of electrochemical paper‐based analytical devices (ePADs) fabricated by pencil drawing for detecting metamizole, paracetamol and midazolam maleate in whiskey. Different types of paper substrates and graphite pencils were initially characterized with ferrocyanide. The best results were achieved using vegetal paper and Aquarelle/6B pencils. ePADs revealed a decrease in current signal indicating a short lifetime, thus limiting their use to disposable sensors. Despite the short lifetime, the graphite pencil ePADs revealed good electrochemical reproducibility (RSD=3.3 %). The forensic feasibility of the proposed ePADs was demonstrated through the analysis of metamizole and paracetamol in whiskey. The limit of detection (LOD) achieved for paracetamol and metamizole were 45 and 20 mg L−1, respectively. ePADs were also tested to detect midazolam maleate in whiskey. The signal recorded exhibited linear correlation in a wide concentration range (25–1000 mg L−1) and a LOD of ca. 5 mg L−1. Considering the disposability and operational simplicity, ePADs offer a good strategy for detecting adulterations in alcoholic beverages at the point‐of‐need.

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Section: Introductionmentioning

confidence: 99%

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

et al. 2018

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“…31 The 2D biosensor design operated by using two WEs, one RE (aqueous Ag/AgCl) and one AE (graphite). The first WE was made up of a 2-mm diameter Ti disk coated with a tiny drop of copper conductive ink suspension.…”

Section: ·2 Designs: 2d and 3d Devicesmentioning

confidence: 99%

“…An amperometric PAD that incorporated electrically conductive ink based on Cu nanoparticles, graphite and polystyrene increased the sensitivity of the sensor. 31 A combination of Cu, graphite and polysterene ink were employed for electrode fabrication. Based on the amperometric results, the most suitable formulation for Cu, graphite, and polystyrene were 50, 75 and 22 mg/mL, respectively.…”

Section: ·3 Foodmentioning

confidence: 99%

Trends in Paper-based Electrochemical Biosensors: From Design to Application

et al. 2018

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Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis. The reviewed sensors were classified into categories based on their applications, such as diagnostics, environmental and food testing. One of the major advantages of using paper-based electrochemical sensors is the potential for miniaturization, which only requires relatively small amount of samples, and the low cost for the purpose of mass production. Additionally, most of the devices reviewed were made to be portable, making them well-suited for on-site detection. Finally, paper-based detection is an ideal platform to fabricate cost-effective, user-friendly and sensitive electrochemical biosensors, with large capacity for customization depending on functional needs.

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“…4 This kind of substrate has become increasingly popular for the scientific community due to its operational simplicity, low instrumental requirements and, most importantly, the possibility to be used in point-of-care testing with the sample-in:answer-out capability. [1][2][3][4] Recent examples of paper-based analytical devices (PADs) for lateral flow or spot test assays, [5][6][7] flow-injection analysis, 8,9 chromatographic and electrophoretic separations, 10,11 digital microfluidics, 12 direct analysis using paper spray ionization mass spectrometry [13][14][15] and electroanalytical measurements 16,17 have been successfully reported.…”

Section: Introductionmentioning

confidence: 99%

“…The chronological summary regarding the electrode fabrication methods to be incorporated on paper devices can be found in excellent review articles recently reported. [16][17][18][19][20]24 In general, electrodes can be fabricated on paper by screen-printing, metallic deposition through sputtering or evaporation, microwires, stencil-printing, inkjetprinting, graphite pencil leads and pencil-drawing methods. [18][19][20]25 Pencil-drawn paper supported electrodes were firstly proposed by Dossi and co-workers.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ascorbic Acid in Commercial Tablets Using Pencil Drawn Electrochemical Paper-based Analytical Devices

et al. 2018

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This study describes the use of electrochemical paper-based analytical devices (ePADs) drawn with graphite pencil for the determination of ascorbic acid (AA) in commercial tablets. ePADs were fabricated using vegetal paper and graphite pencil. First, the three-electrode electrochemical cell drawn using a graphical software and toner lines were laser printed on the vegetal paper surface to delimit the electrode areas. Then, the electrode regions were manually painted with graphite pencil. Afterwards, the pseudo-reference electrode was defined with the deposition of silver ink over the graphite surface. Cyclic voltammetry and square wave voltammetry (SWV) experiments were performed to optimize the electroanalytical parameters as well as to quantitatively determine the AA concentration in two commercial tables. ePADs exhibited linear behavior for a concentration range between 0.5 and 3.0 mmol L. The achieved limit of detection and sensitivity were 70 μmol L and 0.47 μA/mmol L, respectively. The AA concentration levels found by SWV experiments in both Cenevit and Energil C were 2.80 ± 0.02 and 3.10 ± 0.01 mmol L, respectively. The accuracy of the proposed devices was investigated through recovery experiments in three concentration levels and it presented values between 95 and 115%.

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Amperometric paper sensor based on Cu nanoparticles for the determination of carbohydrates

Cited by 29 publications

References 20 publications

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

Detection of Analgesics and Sedation Drugs in Whiskey Using Electrochemical Paper‐based Analytical Devices

Trends in Paper-based Electrochemical Biosensors: From Design to Application

Determination of Ascorbic Acid in Commercial Tablets Using Pencil Drawn Electrochemical Paper-based Analytical Devices

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