Amperometric magnetoimmunosensor for ErbB2 breast cancer biomarker determination in human serum, cell lysates and intact breast cancer cells

Electrochemical aptamer/antibody based sandwich immunosensor for the detection of EGFR, a cancer biomarker, using gold nanoparticles as a signaling probe

“…Thus, it can be deduced that the use of an Apt as a capture probe instead of an Ab improves the detection sensitivity of the immunosensor. In another analogues approach, a sandwich immunosensor using Abs (one immobilized on MBs as a capture probe and another conjugated to an enzyme as a reporter), with amperometric detection method, has provided detection limit of 26 pg/mL (Eletxigerra et al 2015). Table 1 presents a comparison of the present study with previous works.…”

Organic distributed feedback laser for label-free biosensing of ErbB2 protein biomarker

“…This LOD value is higher than that achievable with other types of sensors. For example, a LOD as low as 26 pg/mL have been obtained for the ErbB2 biomarker in diluted human serum samples using a highly sensitive amperometric magnetoimmunosensor [19]. However, DFB laser biosensing represents a cost-effective way to detect biomolecules and the DFB laser can be made entirely in polymer [20] or even be completely biocompatible [21].…”

Diagnostics Strategies with Electrochemical Affinity Biosensors Using Carbon Nanomaterials as Electrode Modifiers

“…Electrochemical immunosensors have been extensively used for the determination of diagnostics biomarkers because of the interesting advantages they offer in terms of inherent high sensitivity and selectivity, great precision and accuracy, low cost, minimum sample requirements, simplicity of operation and possible integration into compact analytical devices as well as demonstrated suitability for clinical analysis [33,34,35,36,37,38,39,40]. In the following sections, the most interesting characteristics of selected approaches using carbon nanomaterials as modifiers of electrochemical immunosensing platforms will be briefly discussed.…”