Organic distributed feedback laser for label-free biosensing of ErbB2 protein biomarker

Retolaza, A.; Martínez-Perdiguero, Josu; Merino, S.; Morales-Vidal, Marta; Boj, Pedro G.; Quintana, José A.; Villalvilla, José M.; Díaz-García, María A.

doi:10.1016/j.snb.2015.09.093

Cited by 31 publications

(23 citation statements)

References 25 publications

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“…The right panel shows the laser peaks before functionalization, after functionalization with anti‐ErbB2, after BSA blocking, and after analyte addition at a concentration of 10 ng mL −1 . Adapted with permission . Copyright 2016, Elsevier.…”

Section: Biological and Biomedical Sensingmentioning

confidence: 99%

“…For instance, Lu et al demonstrated the capability of a DFB laser to detect 3.4 × 10 −9 m (60 ng mL −1 ) of human immunoglobulin G (IgG) proteins and microparticles . Retolaza et al developed an organic DFB laser to specifically detect ErbB2 protein biomarker down to 14 ng mL −1 (Figure c) . Strictly speaking, the above two DFB laser examples do not fall into the biolaser definition, as they act merely like passive label‐free optical biosensors.…”

Section: Biological and Biomedical Sensingmentioning

confidence: 99%

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Biological Lasers for Biomedical Applications

Chen

Fan

2019

Advanced Optical Materials

111

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A biolaser utilizes biological materials as part of its gain medium and/or part of its cavity. It can also be a micro‐ or nanosized laser embedded/integrated within biological materials. The biolaser employs lasing emission rather than regular fluorescence as the sensing signal and therefore has a number of unique advantages that can be explored for broad applications in biosensing, labeling, tracking, contrast agent development, and bioimaging. This article reports on the progress in biolasers with focus on the work done in the past five years. In the end, the possible future directions of the biolaser are discussed.

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Section: Biological and Biomedical Sensingmentioning

confidence: 99%

Section: Biological and Biomedical Sensingmentioning

confidence: 99%

Biological Lasers for Biomedical Applications

Chen

Fan

2019

Advanced Optical Materials

111

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“…These systems have shown a very good performance as active material in waveguide‐based organic lasers . Moreover, the potential of distributed feedback lasers based on this active system as refractive index or biological sensors has been recently demonstrated. The chemical structure of PDI‐O and the absorption and FL spectrum of the film used in this work are shown in Figure a.…”

Section: Enhancement Effects Of Plasmonic Patternsmentioning

confidence: 99%

Plasmonic Enhancement in the Fluorescence of Organic and Biological Molecules by Photovoltaic Tweezing Assembly

Elvira

Muñoz-Martínez

Jubera

et al. 2017

Adv Materials Technologies

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“…A distributed feedback (DFB) laser, consisting of a solution-processable waveguide including a diffractive relief grating, has been a particularly successful TFOL which has already demonstrated its applicability, at laboratory scale, as tunable source for spectroscopy [2], amplifiers for optical communications [3,4], vapor explosive chemical sensors [5] and highly sensitive and possibly specific non-intrusive label-free sensors for drug discovery, biological research, diagnostic tests, food safety, etc. [6,7,8,9]. Today, one of the major challenges remaining to bring TFOLs to the real market is to find efficient, photostable, tunable and chemical versatile active material.…”

Section: Introductionmentioning

confidence: 99%

High performance thin film organic lasers for sensing applications

Morales-Vidal¹

2019

Opt. Pura Apl.

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This paper summarizes the most important results of the PhD Thesis presented by M. M-V. and directed by M.A. Díaz-García. Thin film organic lasers have demonstrated its applicability at laboratory scale, spectroscopy, optical communications, chemical sensing or biosensing. To bring optically-pumped solution processed thin film organic lasers to the real market the active material must be: able to emit at low pump excitation (low threshold), photostable to ensure a long operational lifetime; capable of emitting at various wavelengths or colours, processable by low-cost solution-based methods and mechanically flexible. We show all these properties amalgamated in a novel organic active materials: carbon-bridged oligo(p-phenylenevinylene)s (COPVn) dispersed in thermoplastic polymer films and a COPV-polymer prepared as a neat film. Novel devices by using different architectures have been optimized and studied. The high performance achieved with these laser devices has been demonstrated by pumping them with an inexpensive laser diode. The sensing applicability of thin film organic lasers has been also demonstrated by preparing and characterizing bulk refractive index sensors and biosensors.

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Organic distributed feedback laser for label-free biosensing of ErbB2 protein biomarker

Cited by 31 publications

References 25 publications

Biological Lasers for Biomedical Applications

Biological Lasers for Biomedical Applications

Plasmonic Enhancement in the Fluorescence of Organic and Biological Molecules by Photovoltaic Tweezing Assembly

High performance thin film organic lasers for sensing applications

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