Amperometric Determination of Cholesterol-Reducing Drug, Ezetimibe, Using Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotubes and Sodium Dodecylsulfate

Jalali, Fahimeh; Ahmadi, Elham; Roushani, Mahmoud; Bahrami, Gh.; Shamsipur, Mojtaba

doi:10.1080/00032710903502173

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Hypocholesterolemic products were determined in pharmaceuticals formulations using unmodified ) and multi-walled carbon nanotubes-modified glassy carbon electrodes (Jalali et al 2010). Figure 2 shows a typical amperometric graph illustrating the current response of carbon paste electrode in flux injection analysis of benzocaine with injections of the Brought to you by | SUNY Binghamton Authenticated Download Date | 11/18/14 5:23 PM analyte in decreasing concentrations taken from Dejmkova et al (2013).…”

Section: Amperometric Methodsmentioning

confidence: 99%

Voltammetric/amperometric screening of compounds of pharmacological interest

Doménech‐Carbó

Carvalho

Martini

et al. 2014

Reviews in Analytical Chemistry

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Voltammetric and amperometric methods for screening compounds of pharmacological interest are reviewed on the basis of the types of electrodes and analytical strategies. The scope of conventional voltammetric and amperometric methods has been considerably expanded in the last years due to the development of a plethora of modified electrodes, in particular, those involving nanocomposites. The application of solid state voltammetric techniques for pharmacological screening has been also reviewed.

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Section: Amperometric Methodsmentioning

confidence: 99%

Voltammetric/amperometric screening of compounds of pharmacological interest

Doménech‐Carbó

Carvalho

Martini

et al. 2014

Reviews in Analytical Chemistry

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“…However, these techniques present a number of critical drawbacks, including the requirement of expensive solvents and instruments for high-performance liquid chromatography. Thus, efforts have been made to overcome these drawbacks by promoting the use of electroanalytical methods for assaying EZT [28][29][30][31][32][33]. Compared with other techniques, electroanalytical methods advantages an excellent limit of detection (LD � 10 À 12 mol L À 1 ), small sample requirements, and short analysis time.…”

Section: Introductionmentioning

confidence: 99%

An Electrospun Nanofibrous Sensor Based on a Porous (Cr/Zn) Slats Oxide for Voltammetric Detection of Ezetimibe Drug in Real Samples

2021

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Herein, a series of bimetallic slats oxide nanofibers with different molar proportions of Cr: Zn were synthesized via the electrospinning method. Nanofibers with a molar proportion of (Cr: Zn = 1: 2) [CrZn 3 ] demonstrated a large superficial area (123.3 m 2 /g) with minimal resistivity. A modulated carbon paste sensor (MCPS) constructed using 1.0 % of [CrZn 3 ] exhibited remarkable surface electrocatalytic activity for oxidation of ezetimibe drug and oxidation reduction of an electroactive probe (K 3 [Fe(CN 6 )]). Under optimized conditions, the limit of the detection of the obtained MCPS for ezetimibe in bulk form was 0.024 nmol L À 1 and its linear range was 0.08-1.5 nmol L À 1 . The sensor also demonstrated good selectivity toward the drug in human medication and serum fluid.

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“…A linear amperometric calibration curve was obtained in the range of 1.2-78 M (0.5-32.0 g/mL) of ezetimibe, with a sensitivity of 88.6 nA/ M and a detection limit of 300 nM (0.12 g/mL). 13 Reviewing the literature revealed that, up to the present time, nothing has been published concerning the determination of ezetimibe in plasma by electrochemical sensors. The aim of this work is to develop a simple validated, sensitive, and time saving coated wire membrane electrodes for the determination of ezetimibe in pure form, pharmaceutical preparations and biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Cholesterol-Reducing Drug, Ezetimibe Using Coated Wire Membrane Sensors

Alarfaj¹,

Aly²,

El‐Tohamy³

2011

Sen Lett

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Newly developed coated wire membrane electrodes have been developed for determination of ezetimibe (EZ) in pure form, pharmaceutical preparations and in biological fluids. The selective electrodes were based on the incorporation of ezetimibe with the ion exchanger(s) phosphotungstic acid (EZ-PTS), phosphomolybdic acid (EZ-PMO) and a mixture of both (EZ-PTS/PMO). The electrodes exhibit linear response with a Nernstian slope (57 37 ± 0 235, 55 40 ± 0 748 and 58 04 ± 0 536 mV decade −1 at 25 C) over concentration range 1 0 × 10 −6 − 1 0 × 10 −1 , 1 0 × 10 −6 − 1 0 × 10 −2 and 1 0 × 10 −6 − 1 0 × 10 −1 mol L −1 for the three electrodes, respectively. The working pH range of the proposed electrodes was 3-7. The influence of possible interfering species such as common inorganic cations, many sugars, amino acids and different pharmacological related compounds was studied. Statistical student's t-test and F test showed insignificant systematic error between proposed and reported methods.

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Amperometric Determination of Cholesterol-Reducing Drug, Ezetimibe, Using Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotubes and Sodium Dodecylsulfate

Cited by 6 publications

References 23 publications

Voltammetric/amperometric screening of compounds of pharmacological interest

Voltammetric/amperometric screening of compounds of pharmacological interest

An Electrospun Nanofibrous Sensor Based on a Porous (Cr/Zn) Slats Oxide for Voltammetric Detection of Ezetimibe Drug in Real Samples

Potentiometric Determination of Cholesterol-Reducing Drug, Ezetimibe Using Coated Wire Membrane Sensors

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