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Qian, Shuai; Guo, Ruixiang; Dong, Diansheng; Bao, Bocheng; Wang, Shujun; Wu, Wenhui

doi:10.21127/yaoyimr20170004

2017

DOI: 10.21127/yaoyimr20170004

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Shuai Qian¹,

Ruixiang Guo²,

Diansheng Dong³

et al.

Abstract: A lot ofindole compounds possessing complex structures exist widely in alkaloids with enormous research significance. Specifically, bisindoles play a great role in the treatment of cancer, tumors, cardiovascular and cerebrovascular diseases. Many researchers are devoted to their biosynthesis. The structural diversity of bisindoles is attributed to multiple active sites of tryptophan. They presented bioactivities against anti-inflammatory, anti-bacterial, anti-virus and anti-cancer properties at the C-3 site of… Show more

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Cited by 3 publications

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Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Zhang

2020

Archiv der Pharmazie

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The bisindole moiety, as a versatile pharmacophore, is one of the widespread heterocycles in naturally occurring and synthetic bioactive compounds. The bisindole alkaloids derived from natural sources possess structural and mechanistic diversity, and they were found to be generally more active than monoindole alkaloids against various cancer cell lines. Moreover, some bisindole alkaloids such as the tubulin inhibitors, vinorelbine and vinblastine, have already been approved for cancer therapy, suggesting that bisindole alkaloids are a significant source of anticancer agents and lead hits. Bisindole hybrids have the potential to overcome drug resistance, enhance efficiency, and reduce severe side effects. The bisindole–lactam hybrid midostaurin has already been approved for the treatment of adult patients with newly diagnosed acute myeloid leukemia who are FLT3 mutation‐positive, highlighting the importance of bisindole hybrids in the development of novel anticancer agents. In this review, we present a brief account of the bisindole alkaloids derived from nature and of synthetic hybrids with potential anticancer activity developed in the recent 10 years.

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Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Zhang

2020

Archiv der Pharmazie

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Natural indole‐containing alkaloids and their antibacterial activities

Liu

Cui

et al. 2020

Archiv der Pharmazie

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As the growth in resistance to bacterial infection treatments poses a grave threat to global health in the 21st century, there is a constant need to explore novel antibacterial agents that have the ability to overcome drug resistance. Indole-containing alkaloids are widely distributed in nature, and a variety of indole-containing alkaloids have already been applied in clinical practice, proving that indole-containing alkaloids are fascinating and privileged scaffolds for the development of novel drugs. Moreover, indole

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Indole Alkaloids with Potential Anticancer Activity

2020

CTMC

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Indole alkaloids which are abundance in nature are a significant source of pharmacologically active compounds. Indole alkaloids have the potential to exert the anticancer activity via various antiproliferative mechanisms, and some of them such as Vinblastine and Vincristine have already used in clinic or under clinical evaluations for the treatment of cancers. Therefore, indole alkaloids occupy an important position in the discovery of novel anticancer agents. This review emphasizes the recent development of indole alkaloids as potential anticancer agents, their structure-activity relationship and mechanisms of action covering the articles published from 2015 to 2020.

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Cited by 3 publications

References 18 publications

Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Natural indole‐containing alkaloids and their antibacterial activities

Indole Alkaloids with Potential Anticancer Activity

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