“What are my chances of developing COPD if one of my parents has the disease?” A systematic review and meta-analysis of prevalence of co-occurrence of COPD diagnosis in parents and offspring

Abstract

IntroductionIntergenerational associations in chronic obstructive pulmonary disease (COPD) have been well recognized and may result from genetic, gene environment, or exposure to life course factors. Consequently, adult offspring of parents with COPD may be at a greater risk of developing COPD. The aim of this study was to review the prevalence of co-occurrence of COPD in adult offspring with one or both parents having COPD independent of specific genetic variations.MethodsIn total, five databases were searched for original studies in which prevalence of COPD was reported in both offspring (children) and one or both parents. Studies were excluded if COPD was not clearly defined, COPD was linked to specific genetic variations, COPD was combined with other chronic respiratory conditions, or estimates included other first-degree relatives. Data extraction (ie, sample characteristics, prevalence of COPD, and odds ratio [OR] if reported) was completed by two independent reviewers. A meta-analysis of prevalence and OR was conducted, where possible.ResultsOf the 3,382 citations, 129 full texts were reviewed to include eight studies (six case–control, one cross-sectional, and one cohort) reflecting either prevalence of COPD in offspring of parents with COPD (descendent approach, n=3), which ranged from 0% to 17.3%, or prevalence of people with COPD reporting positive parental history of COPD (antecedent approach, n=5), for which the pooled prevalence was 28.6%. Offspring of people with COPD had 1.57 times greater odds (95% confidence interval =1.29–1.93; P<0.001) of having COPD compared with people not having a parental history of COPD.ConclusionThe prevalence of COPD in adult offspring of people with COPD is greater than population-based estimates, and the ORs indicate a higher risk in this group. This offers clinicians a potential strategy for opportunistic screening, early identification, and intervention in this at-risk group.

CONQUEST Quality Standards: For the Collaboration on Quality Improvement Initiative for Achieving Excellence in Standards of COPD Care

“… 62 , 63 Others have found that risk of developing COPD in adulthood can be identified using lifetime lung function trajectory patterns and is 57% greater in those individuals with a parental history. 64 , 65 These risk prediction tools may be used to guide therapy and highlight those most at risk of exacerbations, disease progression, and mortality within the target population.…”

“…62,63 Others have found that risk of developing COPD in adulthood can be identified using lifetime lung function trajectory patterns and is 57% greater in those individuals with a parental history. 64,65 These risk prediction tools may be used to guide therapy and highlight those most at risk of exacerbations, disease progression, and mortality within the target population. a multifactorial approach to assess risk of exacerbations including ongoing smoking, exposure to pollutants, infection, insufficient physical activity, seasonal variation and frequency of exacerbations.…”

Array-based Comparative Genomic Hybridization (aCGH) Reveals Chromosomal Aberrations in Chronic Obstructive Pulmonary Disease (COPD): A Preliminary Study

“…Epidemiological data indeed indicate potential role of genetic factors as it is observed that COPD cases aggregate in families [6]- [8]. Li et al [9] have observed increased prevalence of chronic bronchitis in @ @ @ @ @ @ offspring when one or more parents were affected by the same disease. Also, severe alpha-1-antitrypsin (ATT) deficiency is a known risk factor for the development of COPD [10].…”

Parental and life-course influences on symptomatic airflow obstruction

“…Adult offspring of people with chronic obstructive pulmonary disease (COPD) have nearly 60% higher odds of developing COPD compared with people without a parental history [1]. This relationship may be explained by a complex interaction of COPD risk factors [2], which are present throughout a person's life course [3].…”