&amp;#946;-Adrenomimetic Actions in the Hypotension and Vasodilatation Induced by a Chromatographic Active Fraction from Bidens pilosa L. (Asteraceae) in Mammals

Léandre, Kouakou Kouakou; Claude, Abo Kouakou Jean; Jacques, Datte Yao; Traoré, Flavien; Etienne, Ehile Ehouan

doi:10.2174/157340708784533438

Cited by 3 publications

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“…The chromatographic fractionation of dried B. pilosa leaves on Sephadex gel yields several fractions, of which the active F 2 fraction displays excellent activities on rabbit arterial blood pressure and induces a dose-dependent hypotension (1-25 mg/kg b.w), while it lessened the contractile force of isolated guinea-pig aortas by 10 -12 -10 -1 mg/ml. The hypotension and vasodilatation elicited by fraction F 2 are attenuated by propranolol (a badrenoceptor antagonist), suggesting that fraction F 2 contains b-adrenoceptor antagonist constituents, responsible for the hypotension and the vasodilatation activities (Leandre et al 2008).…”

Section: Arterial Hypertensionmentioning

confidence: 99%

“…Due to their oxytocic effects, decoctions of B. pilosa should not be taken by pregnant women (Noumi et al 1999). In addition, the F 3 chromatographic fraction of the leaf extract of B. pilosa induces hypotension followed by the death of rabbits at high doses (Leandre et al 2008). The extract of the leaves has been used experimentally against snake venoms and found to slightly antagonize D. jamesoni venom and had no effects on anti-venom serum (Marchant 1985).…”

Section: Reproductive Tractmentioning

confidence: 99%

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Chemistry and pharmacology of Bidens pilosa: an overview

Xuan

Khanh

2016

Journal of Pharmaceutical Investigation

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Bidens pilosa L. is an edible herb and has been traditionally used for a wide range of ailments in many countries. The aim of this review is to present comprehensive information of the chemical constituents, nutraceutical and ethnomedical uses as well as the biological and pharmacological effects and toxicity of this plant based on 218 literary sources reported over 40 years. Major chemical constituents (including 301 compounds) belonging to polyacetylenes, polyacetylene glycosides, flavonoids, flavone glycosides, aurones, chalcones, okanin glycosides, phenolic acids, terpenes, pheophytins, fatty acids and phytosterols have been identified or isolated from the different parts of this plant. Many of them have been considered as the bioactive compounds which are potentially responsible for the pharmacological actions. Various types of preparations, extracts and individual compounds derived from this plant have been found to possess biological and pharmacological activities such as anti-malarial, anti-allergy, antihypertensive and smooth muscle relaxant, anti-cancerogenic, anti-diabetic, anti-inflammatory, anti-microbial, antioxidant. The results of data analysis on the chemicals, pharmacological and toxicological characteristics of B. pilosa validate the view of its folk worldwide-medicinal uses. This herb has a great beneficial therapeutic property and is possibly used for complement or alternative to pharmaceutical drugs in some specific cases. However, this herb is known as hyperaccumulator and as-excluder; therefore, harvesting the herb for medicinal uses should be judiciously cautioned.

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Section: Arterial Hypertensionmentioning

confidence: 99%

Section: Reproductive Tractmentioning

confidence: 99%

Chemistry and pharmacology of Bidens pilosa: an overview

Xuan

Khanh

2016

Journal of Pharmaceutical Investigation

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“…Studies of B. pilosa plant extracts have shown it has anti-hyperglycemic [54,55], antihypertensive [56,57,58], antiulcerogenic [45], hepatoprotective [59], antipyretic [60], immunosuppressive and anti-inflammatory [8,61,62], anti-leukemic [63,64], anti-malarial [50], anti-bacterial [48], antioxidant [65,66] and antitumor [67] effects. These proven biological activities have led countries like Brazil to include B. pilosa in the official list of medicinal plants with potential for development of herbal use by the public health system [68].…”

Section: Introductionmentioning

confidence: 99%

Compilation of Secondary Metabolites from Bidens pilosa L.

et al. 2011

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Abstract:Bidens pilosa L. is a cosmopolitan annual herb, known for its traditional use in treating various diseases and thus much studied for the biological activity of its extracts, fractions and isolated compounds. Polyacetylenes and flavonoids, typical metabolite classes in the Bidens genus, predominate in the phytochemistry of B. pilosa. These classes of compounds have great taxonomic significance. In the Asteraceae family, the acetylene moiety is widely distributed in the Heliantheae tribe and some representatives, such as 1-phenylhepta-1,3,5-triyne, are noted for their biological activity and strong long-wave UV radiation absorbance. The flavonoids, specifically aurones and chalcones, have been reported as good sub-tribal level markers. Natural products from several other classes have also been isolated from different parts of B. pilosa. This review summarizes the available information on the 198 natural products isolated to date from B. pilosa.

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Building Research Businesses on Integration of Basic and Applied Research: Value Creation and New Opportunities for the Chemical Enterprise

Chorghade¹

2014

ACS Symposium Series

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β-Adrenomimetic Actions in the Hypotension and Vasodilatation Induced by a Chromatographic Active Fraction from Bidens pilosa L. (Asteraceae) in Mammals

Cited by 3 publications

References 0 publications

Chemistry and pharmacology of Bidens pilosa: an overview

Chemistry and pharmacology of Bidens pilosa: an overview

Compilation of Secondary Metabolites from Bidens pilosa L.

Building Research Businesses on Integration of Basic and Applied Research: Value Creation and New Opportunities for the Chemical Enterprise

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