Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity

Renn, Claudia N.; Straff, Wolfgang; Dorfmüller, A; Al-Masaoudi, Tlaytmas; Merk, Hans F.; Sachs, B.

doi:10.1046/j.1365-2133.2002.05021.x

Cited by 90 publications

(53 citation statements)

References 16 publications

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“…In one study it was reported that 90.7% of IM patients were given antibiotics before hospital admission or serology tests [12]. The incidence of skin rash is higher in the antibiotic treated group than among patients who do not take antibiotics [6,7]. Ampicillin was one of the first drugs which were connected to skin eruptions in IM.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of skin eruption in acute IM is 4.2 to 13% without drug intake [5]. By the frequent use of antibiotics within acute IM, the incidence of skin reactions rises, ranging between 27.8% and 69%; in some past studies for ampicillin even 90% [1,3,6,7]. According to the literature there is no obvious consensus on the cause of skin symptoms, whether a true drug sensitization or only transient immunoactivation develops.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic Induced Cutaneous Rash in Infectious Mononucleosis: Overview of the Literature

Zsuzsanna¹,

Varga²

2015

J Allergy Ther

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibiotic Induced Cutaneous Rash in Infectious Mononucleosis: Overview of the Literature

Zsuzsanna¹,

Varga²

2015

J Allergy Ther

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“…28 Despite these remarks, it is a promising test for the laboratory diagnosis of drug allergies. 9,42,43 Another test used in research concerns the assessment of serum IL-5 levels secreted by peripheral blood mononuclear cells in the presence of the analyzed drug. 44 This test has a diagnostic sensitivity of 92%, which is higher than that of the lymphocyte transformation test (78%) or of the patch tests (55%).…”

Section: Clinical Picture and Diagnosismentioning

confidence: 99%

“…10 The incidence of skin reactions due to the oral administration of ampicillin or amoxicillin during an acute episode caused by the Epstein-Barr virus (infectious mononucleosis) is elevated among children and young adults. 9 Familial susceptibility to AR also has been reported, 11 and may be related to different metabolic pathways of the drug, and to the antigenic process.…”

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confidence: 99%

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Reações alérgicas a medicamentos

Nagão-Dias¹,

Barros-Nunes²,

Coêlho³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: This review addresses the most recent published literature regarding drug allergy, in order to provide physicians with a background for a better understanding of this problem of great relevance for public health. Sources of data:The sources of data for obtaining the original and review articles published in the last 10 years were MEDLINE, Pubmed and Lilacs. The articles chosen for this review relate drug allergy to immunological mechanisms, epidemiology, clinical and laboratory evaluation, skin lesions, clinical management, and re-exposure to the drug.Summary of the findings: Allergic reactions represent one third of adverse drug reactions. They are considered rare but with high morbimortality. Gell & Coombs definition has been useful for classifying some types of drug allergic reactions; however, some still remain without classification because of poor knowledge of the mechanisms involved. The existence of T cell subpopulations with diverse characteristics reveals the complexity of the subject and, at the same time, elucidates several questions raised about it. It was recently postulated a new concept of chemically inert drug presentation to T cells, restricted to the major histocompatibility complex, but in a non-covalent and labile way. In clinical practice, without adequate laboratory tests, it is difficult to correlate clinical symptoms and immunological mechanisms. In vitro and in vivo skin tests have been employed in cases of suspected drug allergy reaction. However, there are very few commercially available reagents.Conclusions: Drug allergy constitutes an important problem in adverse drug reactions because of its potential of morbidity and mortality. It is necessary to emphasize the relevance of pharmacovigilance during treatment of patients, as well as the identification of possible immunological mechanisms involved in the events, through laboratory tests and detailed history and clinical evaluation.

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Drug Reactions

Breathnach¹

2004

Rook's Textbook of Dermatology

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Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity

Abstract: These data suggest that real sensitization to amoxicillin and ampicillin may occur within infectious mononucleosis and may be detected in vivo and in vitro by means of skin tests and the LTT.

Cited by 90 publications

References 16 publications

Antibiotic Induced Cutaneous Rash in Infectious Mononucleosis: Overview of the Literature

Antibiotic Induced Cutaneous Rash in Infectious Mononucleosis: Overview of the Literature

Reações alérgicas a medicamentos

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