Amorphous ultrafine particle preparation for improvement of bioavailability of insoluble drugs: grinding characteristics of fine grinding mills

Comparative antioxidant activity of nanoscale lignin prepared by a supercritical antisolvent (SAS) process with non-nanoscale lignin

“…On the other hand, the nanoscale lignin reached dissolution equilibrium within 2 h, but the non-nanoscale lignin over 4 h. Perrut, Jung, and Leboeuf (2005) believed the dissolution rate of poorly-soluble active ingredients can be increased by transforming its particles into nano-particles. At the same time, according to Noyes-Whitney theory, one of the most important features of nanoparticles is to increase dissolution velocity of a compound (Choi et al, 2004;Mosharraf & Nyström, 1995).…”

An investigation into lactose crystallization under high temperature conditions during spray drying

“…For powderproducing industries, attaining the required extent of crystallinity in the powder material is very important (Giron, 2002;Vromans, Bolhuis, Lerk, van de Biggelaar, & Bosch, 1987), because these partially-crystalline materials significantly affect further processing steps, including the following aspects: compressing tablets (Bernabe et al, 1995;Di Martino et al, 1993;Fell & Newton, 1971); dissolution behaviour of the product (Burt & Mitchell, 1981;Giron, 2002); functionality (activity, toxicity, stability) of the product (Giron, 2002); stability (Pikal, Lukes, Lang, & Gaines, 1978); flowability (Chan & Chew, 2003;Fitzpatrick et al, 2007); porosity (Trivedi & Axe, 2001); bioavailability (Briggner, Buckton, Bystrom, & Darcy, 1994;Buckton & Darcy, 1995;Choi et al, 2004;Hancock & Zografi, 1997); and finished product shelf-life (including caking and agglomeration (Aguilera, del Valle, & Karel, 1995;Downton, Flores-Luna, & King, 1982).…”

Nanocrystal Suspension of Cefixime Trihydrate Preparation by High-Pressure Homogenization Formulation Design Using 23 Factorial Design

“…A major hurdle that has prevented the commercialization of many promising poorly soluble drugs is dissolution rate limited bioavailability. Many approaches have been developed to improve solubility and to enhance the dissolution rate and oral bioavailability of poorly soluble drugs e. g. salt formation [5][6][7] solid dispersion [8][9][10] inclusion complex [11]. Cefixime trihydrate, an orally active third generation cephalosporin antibiotic, is extensively used for the treatment of urinary tract infection (UTI), upper and lower respiratory tract infection, acute otitis media, and Gonococcal urethritis [12].…”