Amorphous metal–organic frameworks for drug delivery

Orellana-Tavra, Claudia; Baxter, Emma F.; Tian, Tian; Bennett, Thomas D.; Slater, Nigel K.H.; Cheetham, Anthony K.; Fairen‐Jimenez, David

doi:10.1039/c5cc05237h

Cited by 339 publications

(253 citation statements)

References 21 publications

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“…The versatility of the click modulation technique is further demonstrated by its compatibility with cargo loading (Supplemental Information, Section S6). Simply stirring azide-modified UiO-66-L1 in a concentrated methanolic calcein solution resulted in higher incorporation of calcein (16.0% w/w as determined by UV-Vis spectroscopy) than previously reported in the literature for UiO-66, most likely as a result of the increased porosity of UiO-66-L1 60 . We named the calcein-loaded sample cal@UiO-66-L1.…”

Section: Resultsmentioning

confidence: 90%

“…In order to determine the effect of the PEGylation upon drug-release kinetics and cell internalization routes, we chose calcein as a model drug because of its structural similarities to doxorubicin 2, 60. Calcein is hydrophilic and does not permeate the cell membrane; rather, it requires a drug-delivery vehicle to facilitate its entry into cells.…”

Section: Resultsmentioning

confidence: 99%

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Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Lázaro

Haddad

Sacca

et al. 2017

Chem

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293

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SummaryThe high storage capacities and excellent biocompatibilities of metal-organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation of surface functionality is a route to enhanced properties, and here we report on a surface-modification procedure—click modulation—that controls their size and surface chemistry. The zirconium terephthalate MOF UiO-66 is (1) synthesized as ∼200 nm nanoparticles coated with functionalized modulators, (2) loaded with cargo, and (3) covalently surface modified with poly(ethylene glycol) (PEG) chains through mild bioconjugate reactions. At pH 7.4, the PEG chains endow the MOF with enhanced stability toward phosphates and overcome the “burst release” phenomenon by blocking interaction with the exterior of the nanoparticles, whereas at pH 5.5, stimuli-responsive drug release is achieved. The mode of cellular internalization is also tuned by nanoparticle surface chemistry, such that PEGylated UiO-66 potentially escapes lysosomal degradation through enhanced caveolae-mediated uptake. This makes it a highly promising vector, as demonstrated for dichloroacetic-acid-loaded materials, which exhibit enhanced cytotoxicity. The versatility of the click modulation protocol will allow a wide range of MOFs to be easily surface functionalized for a number of applications.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Lázaro

Haddad

Sacca

et al. 2017

Chem

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293

158

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“…Zeolite imidazolate frameworks (ZIFs) is a class of materials composed of metal ion and dimethyl imidazole linker, and in view of the special 3D network structure and flexible adjustability, they have widely used in many fields including gas storage/separation, drug delivery, electrode materials, and catalysis . Recently, zinc‐based ZIF‐8 shows great potential as carbon precursor in the fabrication of Fe–N–C, because Zn vaporizes at above 900 °C, leaving N‐doped carbon skeletons with homogenous pore, beneficial for the diffusion of the reactants during catalysis .…”

Section: Introductionmentioning

confidence: 99%

ZIF‐8 with Ferrocene Encapsulated: A Promising Precursor to Single‐Atom Fe Embedded Nitrogen‐Doped Carbon as Highly Efficient Catalyst for Oxygen Electroreduction

Wang

Han

Wang

et al. 2018

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The oxygen reduction reaction (ORR) plays an important role in the fields of energy storage and conversion technologies, including metal-air batteries and fuel cells. The development of nonprecious metal electrocatalysts with both high ORR activity and durability to replace the currently used costly Pt-based catalyst is critical and still a major challenge. Herein, a facile and scalable method is reported to prepare ZIF-8 with single ferrocene molecules trapped within its cavities (Fc@ZIF-8), which is utilized as precursor to porous single-atom Fe embedded nitrogen-doped carbon (Fe-N-C) during high temperature pyrolysis. The catalyst shows a half-wave potential (E ) of 0.904 V, 67 mV higher than commercial Pt/C catalyst (0.837 V), which is among the best compared with reported results for ORR. Significant electrochemical properties are attributed to the special configuration of Fc@ZIF-8 transforming into a highly dispersed iron-nitrogen coordination moieties embedded carbon matrix.

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“…[17,18] Because of their unique properties of adjustable surface area, controllable porosity and tunable structure, MOFs have gained growing interests and presented extensive applications in gas storage/separation, [19][20][21][22][23] drug delivery, [24][25][26][27] electrode materials [28][29][30][31] and catalysis. [17,18] Because of their unique properties of adjustable surface area, controllable porosity and tunable structure, MOFs have gained growing interests and presented extensive applications in gas storage/separation, [19][20][21][22][23] drug delivery, [24][25][26][27] electrode materials [28][29][30][31] and catalysis.…”

Section: Introductionmentioning

confidence: 99%

Metal‐Organic Framework‐Derived Non‐Precious Metal Nanocatalysts for Oxygen Reduction Reaction

Zhu

Song

et al. 2017

Advanced Energy Materials

321

167

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By virtue of diverse structures and tunable properties, metal‐organic frameworks (MOFs) have presented extensive applications including gas capture, energy storage, and catalysis. Recently, synthesis of MOFs and their derived nanomaterials provide an opportunity to obtain competent oxygen reduction reaction (ORR) electrocatalysts due to their large surface area, controllable composition and pore structure. This review starts with the introduction of MOFs and current challenges of ORR, followed by the discussion of MOF‐based non‐precious metal nanocatalysts (metal‐free and metal/metal oxide‐based carbonaceous materials) and their application in ORR electrocatalysis. Current issues in MOF‐derived ORR catalysts and some corresponding strategies in terms of composition and morphology to enhance their electrocatalytic performance are highlighted. In the last section, a perspective for future development of MOFs and their derivatives as catalysts for ORR is discussed.

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Amorphous metal–organic frameworks for drug delivery

Abstract: We report the encapsulation of the hydrophilic model molecule calcein in the Zr-based MOF UiO-66, followed by amorphization of the framework by ball-milling. We show controlled release of calcein over more than 30 days, compared with the 2 day release period from crystalline UiO-66.

Cited by 339 publications

References 21 publications

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

ZIF‐8 with Ferrocene Encapsulated: A Promising Precursor to Single‐Atom Fe Embedded Nitrogen‐Doped Carbon as Highly Efficient Catalyst for Oxygen Electroreduction

Metal‐Organic Framework‐Derived Non‐Precious Metal Nanocatalysts for Oxygen Reduction Reaction

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