Amniotic Membrane Transplantation or Conjunctival Limbal Autograft for Limbal Stem Cell Deficiency Induced by 5-fluorouracil in Glaucoma Surgeries

Pires, Renato T. F.; Chokshi, Amit R.; Tseng, Scheffer C.G.

doi:10.1097/00003226-200005000-00005

Cited by 69 publications

(26 citation statements)

References 25 publications

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“…Although corneal damage due to subconjunctival 5-FU therapy after unsuccessful glaucoma surgery is frequently reported [4], only a few papers have reported the occurrence of corneal epitheliopathy by systemic administration of 5-FU [5]. In contrast, LPI is a widely known adverse effect of systemic 5-FU therapy [6].…”

Section: To the Editormentioning

confidence: 99%

Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

Sato¹,

Nishimura²

2013

TOOPHTJ

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We report the incidence of lacrimal passage impairment and specific features of corneal epitheliopathy as adverse effects of the oral anticancer drug S-1, and examine the relationship between the two pathologies. We conducted a retrospective chart review of 84 patients prescribed the anticancer drug S-1. The incidence of lacrimal passage impairment and corneal epitheliopathy was 8% and 6%, respectively. Three patients experienced both pathologies, demonstrating a moderate probability of both occurring in the same patient (kappa coefficient = 0.46). The findings show that lacrimal passage impairment and specific features of corneal epitheliopathy are likely to occur in the same individual as adverse effects of S-1.

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Section: To the Editormentioning

confidence: 99%

Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

Sato¹,

Nishimura²

2013

TOOPHTJ

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“…To avoid such extensive surface reconstruction, there may be a tendency to create relatively smaller defects, which in some instances may even contribute to the increase of recurrences. Furthermore, large tissue removal and the accompanying inflammation secondary to adjunctive cryotherapy and/or other conventional therapies might result in a myriad of fearsome collateral damages, among them partial limbal stem cell deficiency,[72] compromised wound healing, scarring, granulation tissue formation, motility restriction, and partial or total limbal stem cell deficiency,[73] corneal pannus and scarring, symblepharon, pseudopterygium,[7475] cataract, uveitis, and retinal breaks. [66]…”

Section: Management Of Precancerous and Cancerous Ocular Surface Tumorsmentioning

confidence: 99%

Ocular surface tumors

Othman

2009

Oman J Ophthalmol

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Tumors of the conjunctiva and cornea comprise a large and varied spectrum of conditions. These tumors are grouped into two major categories of congenital and acquired lesions. The acquired lesions are further subdivided based on origin of the mass into surface epithelial, mucoepidermoid, melanocytic, vascular, fibrous, neural, histiocytic, myxoid, myogenic, lipomatous, lymphoid, leukemic, metastatic and secondary tumors. Ocular surface tumors include a variety of neoplasms originating from squamous epithelium, melanocytic tumors and lymphocytic resident cells of the conjunctival stroma. In this review, we highlight clinical features of these lesions, important diagnostic and investigative tools and standard care of management.

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“…Examples include topical 5-fluorouracil (FU), mitomycin C (MMC), generic form of nonsteroidal anti-inflammatory drugs (NSAID), aminoglycosides, and trimethoprim sulfate [24,75,76]. In some of these reports this may be related to either preservatives or to a patient selection bias, because patients with epithelial problems may have been more likely to receive prolonged topical drugs.…”

Section: Iatrogenic Factorsmentioning

confidence: 99%

Graft failure: II. Ocular surface complications

Al-Swailem

2007

Int Ophthalmol

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Risk factors for corneal transplantation failure include both immunologic factors, such as graft rejection, corneal neovascularization, and peripheral anterior synechiae, as well as non-immunologic factors, such as ocular surface disorders (OSD) and glaucoma. This review highlights the necessity of having healthy ocular surface epithelia, tears, and eyelids. It presents different types of OSD, their underlying pathology, and their impact on native cornea and corneal grafts. In addition, a range of proposed donor and surgical factors influencing surface integrity following corneal transplant are addressed. Current medical and surgical research, both pre- and post-operative that promise to further improve the outcome of corneal grafts in the context of OSD are discussed.

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Amniotic Membrane Transplantation or Conjunctival Limbal Autograft for Limbal Stem Cell Deficiency Induced by 5-fluorouracil in Glaucoma Surgeries

Cited by 69 publications

References 25 publications

Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

Ocular surface tumors

Graft failure: II. Ocular surface complications

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