Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia

Solomon, Abraham; Pires, Renato T. F.; Tseng, Scheffer C.G.

doi:10.1016/s0161-6420(00)00567-4

Cited by 256 publications

(179 citation statements)

References 38 publications

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“…Also, any progression in eyes with grade 3 appearance to corneal recurrence was not observed during the follow-up. In studies by Ma et al 25 and Solomon et al, 26 the overall (conjunctival and corneal) recurrence rates after AMT were reported as 25% (12 of 48 eyes) and 28.6% (6 of 21 eyes), respectively. The findings of our study regarding overall recurrence were higher (10/32, 31.2% in fibrin glue group and 13/38, 34.2% in suture group), but comparable to these studies.…”

Section: Discussionmentioning

confidence: 96%

“…Moreover, the use of mitomycin C may result in serious complications and is commonly reserved for the recurrent cases. Solomon et al 26 reported a lower recurrence rate (3%) when AMT was combined with intraoperative triamcinolone. Depot steroids have been reported to be effective in decreasing post-operative inflammation and preventing pterygium recurrence.…”

Section: Discussionmentioning

confidence: 98%

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Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

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Purpose To compare the results of amniotic membrane transplantation (AMT) using fibrin glue vs vicryl sutures in pterygium surgery. Methods We carried out a prospective, randomised clinical study of 70 eyes (70 patients) with primary pterygium. After the removal of pterygium, patients were randomised to undergo AMT using fibrin glue (Tisseel, 32 eyes) or 8-0 vicryl sutures (38 eyes). Clinical examination and digital photographing were performed at each visit and the patients were followed up for at least 12 months. Post-operative symptoms in the first month were evaluated according to a fivepoint scale. Final appearances were graded from 1 to 4 in which grade 4 represented true (corneal) recurrence and grade 3 indicated conjunctival recurrence. Results The average operation time in the fibrin glue and suture groups were 11.2 ± 2.4 min (mean ± SD) and 18.7 ± 2.2 min, respectively (P ¼ 0.018). Significantly fewer post-operative symptoms were observed in the fibrin glue group at post-operative days 1, 7, and 14 (Po0.05 for all). At the end of the follow-up, true recurrence (grade 4) was developed in three eyes (9.4%) in the fibrin glue group, and in four eyes (10.5%) in the suture group (P ¼ 0.33). The rates of conjunctival recurrence (grade 3) were 21.9% (seven eyes) and 23.7% (nine eyes) in the fibrin glue and suture groups, respectively (P ¼ 0.38). Conclusions Amniotic membrane grafts can be successfully attached without any major complication in patients undergoing pterygium surgery. In addition, it is effective in shortening the duration of surgery and preventing post-operative discomfort. Although there seems to be no difference in the recurrence rates and cosmetic outcomes between both groups, neither technique represents best results.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Küçükerdönmez

Karalezlı

Akova

et al. 2009

Eye

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“…Studies have also demonstrated the efficacy of amniotic membrane (AM) graft fixation in conjunction with pterygium surgery as a suitable alternative to conjunctival autografting in cases of large conjunctival defects [74]. Jain et al used fibrin glue for attaching human AM grafts after primary pterygium excision [75].…”

Section: Pterygium Surgerymentioning

confidence: 99%

Tissue adhesives in ocular surgery

Park

Champakalakshmi

Panengad

et al. 2011

Expert Review of Ophthalmology

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“…2 However, many regard it to be a consequence of ultraviolet-induced damage with subsequent elastoid degeneration of the subepithelial connective tissue, [3][4][5] and it is strongly related to ocular sun exposure. [6][7][8][9] The prevalence rates of pterygium obtained from a number of populations range from 1.2% in urban Caucasians 9 to 31.01% in rural Chinese in southern China.…”

Section: Introductionmentioning

confidence: 99%

Pterygium in an aged Mongolian population: a population-based study in China

Lü

Wang

Lü

et al. 2007

Eye

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Aims To determine the prevalence and identify associated risk factors for pterygium in an elderly Mongolian population at high altitude in Henan County, China. Methods A population-based survey was conducted from June 2006 to September 2006. A stratified, clustered, random sampling procedure was used to select 2486 Mongolian people aged 40 years and older. Pterygium was diagnosed and graded clinically as grade 1 (transparent), 2 (intermediate), and 3 (opaque). Risk factors associated with pterygium were evaluated with logistic regression models. Results From 2486 eligible subjects, 2112 (84.9%) were examined. There were 378 people with either unilateral (n ¼ 228) or bilateral (n ¼ 150) pterygia, equivalent to an overall prevalence of 17.9% (95% confidence interval (CI) 16.3, 19.5). The prevalence increased with older age (v 2 -test of trend Po0.001). Visual acuity decreased with higher group of pterygium (v 2 ¼ 97.759, Po0.0001). Pterygium was independently associated with Schirmer's test (p5 mm) (odds ratio (OR) 2.4; 95% CI, 1.9, 3.1), tear breakup time (p10 s) (OR 2.3; 95% CI, 1.8, 2.9), lower education level (o3 years) (OR 2.1; 95% CI, 1.4, 3.2), increasing age (OR 2.0; 95% CI, 1.4, 2.8) for persons 70-79, compared with 40-49, and other risk factors. Conclusions The prevalence of pterygium in an older Mongolian population at high altitude is high, primarily because of ocular sun exposure and the other effects of the unique plateau climate, and representing an important health problem. People should be strongly encouraged to wear a wide-brimmed hat and/or sunglasses whenever they are outside.

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Amniotic membrane transplantation after extensive removal of primary and recurrent pterygia

Cited by 256 publications

References 38 publications

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Amniotic membrane transplantation using fibrin glue in pterygium surgery: a comparative randomised clinical trial

Tissue adhesives in ocular surgery

Pterygium in an aged Mongolian population: a population-based study in China

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