Amniotic fluid index in normal pregnancy: An assessment of gestation specific reference values among Indian women

Abstract

Amniotic fluid index values differ in different populations. We standardized the reference values for normal AFI in Indian women. We found that they are lower in the population studied compared with reported values in the Caucasian population, but slightly higher than the Chinese population.

Curve of amniotic fluid index measurements in low‐risk pregnancy

“…When the 50th percentile AFI was compared with that reported in a Chinese study (14), measurements were always higher in our population at all gestational ages by approximately 50 mm up to 28 weeks, and by 30–40 mm between 32 and 40 weeks of pregnancy. On the other hand, the current 50th percentile showed fewer variations, around 10 mm at all gestational ages, compared to the results of the Indian study population (15).…”

“…The authors of a Chinese curve derived from a large population study suggest that different normality reference curves are needed to establish AFI in different populations (14). Recently, other similar studies carried out in India and Vietnam with a smaller sample size, reached similar conclusions (15, 16). A longitudinal assessment of AFI, performed in the UK, also showed lower limits significantly higher than those of cross‐sectional studies, with probable different clinical performance (17).…”

Peripartum outcomes of high‐risk pregnancies complicated by oligo‐ and polyhydramnios: A prospective longitudinal study

“…A specific association between race and an amniotic fluid volume is uncertain. Studies of normal volumes for the AFI in different populations and the variances in the normal ranges suggest that normal AFI measurements may vary between races 19,20 . The association of pre‐existing diabetes and polyhydramnios is well‐known 21 .…”

Perinatal outcome in terminal oligohydramnios

“…It progressively rises from 10 -20 ml at 10 weeks gestation to ~ 250ml at 16 weeks reaching ~ 800 ml at 33 weeks and reaching a plateau ~ 1000 ml at 38 -39 weeks before finally decreasing to ~ 800 ml at 40 weeks. [2][3][4][5] Although the etiology is complex, it is mostly associated with conditions like renal agenesis, placental dysfunction, congenital anomalies, under nutrition, PIH, hydration anemia and hypoxia.…”