Amniocentesis is a safe and effective prenatal diagnostic tool: a clinical study in Eastern India

Mukherjee, Kanchan; Chaudhury, Kalyansree

doi:10.18203/2320-1770.ijrcog20150705

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…In order to evaluate the health of the fetus, Alvarez performed an amniocentesis in Uruguay in 1950. 4 Our objective was to study the indications and complications of amniocentesis.…”

Section: Discussionmentioning

confidence: 99%

Indications and Complications of Amniocentesis in 16–20 Weeks in a Tertiary Center in Northern Kerala: A Descriptive Study

Devarajan,

Chandran,

Puthiyakam

et al. 2024

International Journal of Infertility &Amp; Fetal Medicine

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As a result, there are well-established screening and diagnostic programs to identify the most prevalent autosomal trisomies in liveborn newborns, including Down syndrome. 2 IntroductIonChromosomal abnormalities in fetuses can have minor to severe repercussions, such as severe physical and mental impairment and a short lifetime. Despite significant advancements in medical research, it is still difficult to diagnose chromosomal abnormalities in fetuses. Trisomies 21, 18, 13, monosomy X, and other sex chromosome aneuploidies are the most frequent chromosomal abnormalities found in infants. 1 The most frequent reason for invasive prenatal testing is the prenatal detection of fetal chromosomal disorders. More than 50% of clinically confirmed early pregnancy losses involve chromosomal abnormalities. Aneuploid fetuses are responsible for 6-11% of stillbirths and neonatal mortality. Around 0.65% of newborns have chromosomal abnormalities that are compatible with life but cause significant morbidity, and 0.2% of newborns have structural chromosomal rearrangements that will eventually impact reproduction. 2 Prenatal genetic diagnostic testing aims to ascertain with as much accuracy as possible if the fetus has a certain genetic illness or condition. Prenatal genetic testing, in contrast, aims to determine if a patient is more likely than not to have a fetus affected by a genetic condition. 3 1,2,4

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“…In order to evaluate the health of the fetus, Alvarez performed an amniocentesis in Uruguay in 1950. 4 Our objective was to study the indications and complications of amniocentesis.…”

Section: Discussionmentioning

confidence: 99%

Indications and Complications of Amniocentesis in 16–20 Weeks in a Tertiary Center in Northern Kerala: A Descriptive Study

Devarajan,

Chandran,

Puthiyakam

et al. 2024

International Journal of Infertility &Amp; Fetal Medicine

View full text Add to dashboard Cite

show abstract

“…Therefore, more research is needed to obtain clearer information. Amniocentesis is performed in pregnant women aged 35 years and older because the mother's chances of having a child with chromosomal abnormalities increase (Xiao, Yang, Zhang, Liao, Zhao, & Liao, 2016), as well as in mothers who have previously had a child with problems such as Down syndrome (Mukherjee & Chaudhury, 2015). Another important application of amniocentesis is in twin pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

Masihi¹,

Shahbazian²,

Barati³

et al. 2020

JMBR

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Introduction: Amniocentesis is one of the most widely used diagnostic interventions but despite its many advantages, it has side effects such as fetal loss. The importance of fetal loss after amniocentesis in twin pregnancies is very important and some researchers believe that in twin pregnancies, the risk of fetal loss after amniocentesis is higher than singleton. Therefore, the present study examined the rate of fetal loss after amniocentesis in twin pregnancies compared to singleton pregnancies. Methods: This prospective descriptive-analytical study was performed on 712 mothers with singleton (628 cases) and twin (84 cases) pregnancies who referred to the obstetrics and gynecology clinic of Imam Khomeini Hospital in Ahvaz with Amniocentesis due to several reason during 2016-2020. A questionnaire containing information such as age, gestational age, number of pregnancies, childbirth and abortion, the cause of the diagnostic test, quarterly screening and NT ultrasound, and the result of amniocentesis were completed for patients. Patients were followed up during the first week, two weeks, and 60 days after amniocentesis, and finally data were analyzed by SPSS version24. Results: The mean age of the patients was 31.96 ± 6.33 years and the mean gestational age at amniocentesis for all patients was 15.37 ± 0.7. The mean NT in patients in the two groups did not differ significantly (1.60±0.44 vs 1.54±4.64, p=0.56). the prevalence of preterm in twin mothers was 13.1% and, in the singleton was 1.75% (p = 0.01). The occurrence of fetal loss was 2.4% in the twin group and 2.07% in the singleton group which was not statistically significant (p = 0.56). in the twin group, one (50%) fetal loss occurred in the first week and another one (50%) occurred between 15 and 60 days. But in the singleton group, 7 cases (63.6%) in the first week, 1 case (9%) in 15 to 60 days, and 3 cases (27.3) after more than 60 days lost the fetus. Previous pregnancy records in twins showed that the mean Gravid (p = 0.01), Parity (p = 0.01) and Living child (p = 0.02) in preterm twins' patients were statistically significantly lower than in the term patients. Conclusion: Our findings show that fetal loss following amniocentesis in twin pregnancies does not increase significantly compared to singleton pregnancies. However, our findings require repeated study in bigger sample size and as multi-centered as possible then It can be generalized to wider communities.

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Amniocentesis is a safe and effective prenatal diagnostic tool: a clinical study in Eastern India

Cited by 2 publications

References 10 publications

Indications and Complications of Amniocentesis in 16–20 Weeks in a Tertiary Center in Northern Kerala: A Descriptive Study

Indications and Complications of Amniocentesis in 16–20 Weeks in a Tertiary Center in Northern Kerala: A Descriptive Study

Risk of Fetal Loss after Amniocentesis in Twins Comparing with Singleton Pregnancy

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