Amlodipine-induced gingival overgrowth

Abstract

Gingival overgrowth represents an over-exuberant response to a variety of local and systemic conditions. Certain anticonvulsants, immuno-suppressive drugs and a number of calcium channel blockers have been shown to produce similar gingival overgrowths in certain susceptible patients. Amlodipine is a comparatively new calcium channel blocker and has been used with increasing frequency in the management of hypertension and angina. Although amlodipine is considered as a safe drug, very rarely it may induce gingival overgrowth also. A rare case of amlodipine-induced gingival overgrowth has been reported herein in a 50-year-old female patient. The treatment aspect included Phase-1 therapy, substitution of the drug, the surgical excision and the maintenance and supportive therapy resulting in excellent clinical outcome.

Drug-induced gingival overgrowth: A critical insight into case reports from over two decades

“…Reported cases of gingival enlargements were induced by different drugs; CCBs (50/119 – of which amlodipine-25;[8910111213141516171819202122232425262728] nifedipine-13;[26293031323334353637383940] verapamil-4;[41] felodipine-2;[4243] nisoldipine-1;[44] manidipine-1;[45] and unspecified CCBs-4[46]); phenytoin (11/119);[4748495051525354555657] cyclosporine (31/119);[3546585960616263646566676869707172737475] phenobarbital (4/119);[767778] sodium valproate (3/119 - including one report of congenital drug-induced gingival hyperplasia);[798081] d-penicillamine (2/119);[82] combination oral contraceptive pill-lynestrenol and ethinyl estradiol (1/119);[83] vigabatrin (1/119). [84] Cases of gingival enlargement after combination drug therapy have also been reported; a combination of cyclosporine and CCBs (11/119);[354685...…”

Synthesis, Spectral Characterization and X–Ray Diffraction Studies of some Pd(II) Complexes with Schiff Bases

“…This band is missing in the complexes indicating the absence of water molecule which is further confirmed by TGA analysis. The phenolic oxygen, after the loss of OH proton gets coordinated to the metal is further supported by the shift in the stretching frequency of the υ (C-O) to lower wave numbers by 20-30 cm -1 from its position in the free ligands1 10,11 . The coordination of azomethine nitrogen is confirmed by the presence of bands in the 1625-1600cm -1 region in the ligand which underwent a shift to a lower frequency after complexation 12 .…”

Amlodipine‐induced gingival enlargement

“…It may take from 1 to 8 weeks for resolution of gingival overgrowth after discontinuing the offending agent 3.…”