Amiodarone-Induced Sinus Arrest Successfully Treated with Ephedrine and Isoproterenol

Navalgund, A.; Alifimoff, James K.; Jakymec, Andres J.; Bleyaert, Achiel L.

doi:10.1213/00000539-198604000-00020

Cited by 19 publications

(3 citation statements)

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“…TS enzyme levels exhibit a significant increase in rapidly proliferating cells compared to resting cells. When resting cells are stimulated to proliferate, TS activity remains unchanged until DNA replication begins, at which point it increases by at least 10-fold during the S-phase [ 34 ]. TS mRNA content also shows a 10-fold increase as cells progress from G0 through S-phase.…”

Section: Discussionmentioning

confidence: 99%

Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease

Kim,

Ryu,

Lee

et al. 2023

IJMS

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Coronary artery disease (CAD) is a prevalent cardiovascular condition characterized by the accumulation of plaque within coronary arteries. While distinct features of CAD have been reported, the association between genetic factors and CAD in terms of biomarkers was insufficient. This study aimed to investigate the connection between genetic factors and CAD, focusing on the thymidylate synthase (TS) gene, a gene involved in DNA synthesis and one-carbon metabolism. TS plays a critical role in maintaining the deoxythymidine monophosphate (dTMP) pool, which is essential for DNA replication and repair. Therefore, our research targeted single nucleotide polymorphisms that could potentially impact TS gene expression and lead to dysfunction. Our findings strongly associate the TS 1100T>C and 1170A>G genotypes with CAD susceptibility. We observed that TS 1100T>C polymorphisms increased disease susceptibility in several groups, while the TS 1170A>G polymorphism displayed a decreasing trend for disease risk when interacting with clinical factors. Furthermore, our results demonstrate the potential contribution of the TS 1100/1170 haplotypes to disease susceptibility, indicating a synergistic interaction with clinical factors in disease occurrence. Based on these findings, we propose that polymorphisms in the TS gene had the possibility of clinically useful biomarkers for the prevention, prognosis, and management of CAD in the Korean population.

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Section: Discussionmentioning

confidence: 99%

Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease

Kim,

Ryu,

Lee

et al. 2023

IJMS

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“…O fentanil pode causar bradicardia em doses maiores como as que são administradas em cirurgias cardíacas. Foi imputado à associação fentanil-amiodarona substancial instabilidade hemodinâmica durante o período peri-operatório 12,13 . Entretanto, esse opióide pode ser administrado com segurança, em pacientes impregnados com amiodarona 14 .…”

Section: Considerações Pré-operatóriasunclassified

“…High fentanyl doses, such as those administered for heart surgery, may promote bradycardia. Substantial hemodynamic instability has been ascribed to the perioperative association of fentanyl and amiodarone 12,13 . However, this opioid may be safely administered to amiodarone-impregnated patients 14 .…”

Section: Preoperative Considerationsmentioning

confidence: 99%

Manuseio peri-operatório do paciente em uso de amiodarona

Ramos

Filho

Pereira

et al. 2004

Rev. Bras. Anestesiol.

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Amiodarone, although normally safe and effective, may present adverse effects, especially on cardiovascular system, during anesthetic-surgical procedures. This is possibly due to interactions between this drug and anesthetic agents mainly related to general anesthesia. There are reports on severe, treatment - resistant bradycardias as well as on different degrees of atrioventricular block (AVB). Patients should be carefully monitored, especially during major procedures, and vasoactive drugs (isoproterenol) and temporary artificial pacemaker, should be available because they may be critical during the adverse effects treatment.

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New Concepts of Antiarrhythmic Strategies

Atlee

1999

Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.

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Amiodarone-Induced Sinus Arrest Successfully Treated with Ephedrine and Isoproterenol

Cited by 19 publications

References 0 publications

Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease

Association of Thymidylate Synthase (TS) Gene Polymorphisms with Incidence and Prognosis of Coronary Artery Disease

Manuseio peri-operatório do paciente em uso de amiodarona

New Concepts of Antiarrhythmic Strategies

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