Aminopropyl-functionalized mesoporous silica SBA-15 as drug carrier for cefazolin: adsorption profiles, release studies, and mineralization potential

Szewczyk, Adrian; Prokopowicz, Magdalena; Sawicki, Wiesław; Majda, Dorota; Walker, Gavin

doi:10.1016/j.micromeso.2018.07.046

Cited by 44 publications

(27 citation statements)

References 70 publications

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“…After further 14 days of pellets incubation in SBF (28 days in total), the spherical particles formed closely to each other and reorganized into the continuous layer. Based on both the results obtained for powders and our previous reports [19,20], the randomly formed clusters which spread over the pellets surface are characteristic for carbonate hydroxyapatite. Furthermore, the hydroxyapatite clusters changed their morphology after 28 days of immersion in SBF into porous, spongy-like one.…”

Section: In Vitro Mineralization Of Dox-30cap@msi Pelletssupporting

confidence: 56%

“…For the drug-loading experiment, the doxycycline hydrochloride (DOX, Sigma-Aldrich) was used as the model, water soluble antibiotic. For the drug-loading experiment, the immersion procedure was applied as described in our previous reports [19,20]. Briefly, DOX was first dissolved in purified water (10 mg/mL).…”

Section: Formulation Of Drug Delivery Systemsmentioning

confidence: 99%

“…Ide et al [42] claimed that the calcination process of MSi results with the low concentration of surface silanol groups. Therefore, low concentration of silanols impedes the composite-DOX interactions (ionic, hydrogen bonding) which are crucial for prolonged drug delivery systems [19,20]. In case of DOX-30CaP@MSi powders, the high burst release was also the result of DOX location (at least in part) out of the pores what is characteristic for the performed adsorption method (adsorption from concentrated solution).…”

Section: Dox Adsorption Onto the 30cap@msimentioning

confidence: 99%

“…To prove these claims, the release kinetics studies have been performed. For spherical particles with a granular matrix containing a water soluble drug, the release kinetics may be described using Kosmeyer-Peppas or Higuchi models [20,51]. Therefore, the release kinetic parameters for both the DOX-30CaP@MSi powders and pellets were calculated using linearized forms of Korsmeyer-Peppas and Higuchi models as presented in Eqs.…”

Section: Dox Adsorption Onto the 30cap@msimentioning

confidence: 99%

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Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Prokopowicz

Szewczyk

Skwira

et al. 2019

Drug Deliv. and Transl. Res.

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We reported the new biphasic composites of calcium phosphate and mesoporous silica material (CaP@MSi) in the form of powders and pellets as a potential bone drug delivery system for doxycycline hydrochloride (DOX). The CaP@MSi powders were synthesized by cationic surfactant-templating method. The effects of 10, 20, and 30% CaP content in the CaP@MSi powders on the molecular surface structure, the cytotoxicity against osteoblast cells in vitro, and the mineralization potential in simulated body fluid were investigated. The CaP@MSi characterized by the highest mineralization potential (30% CaP content) were used for DOX adsorption and pelletization process. The CaP which precipitated in the CaP@MSi composites was characterized as calcium-deficient with the Ca:P molar ratio between 1.0 and 1.2. The cytotoxicity assays demonstrated that the CaP content in MSi increases osteoblasts viability indicating the CaP@MSi (30% CaP content) as the most biocompatible. The combination of CaP and MSi was an effective strategy to improve the mineralization potential of parent material. Upon immersion in simulated body fluid, the CaP of composite converted into the bone-like apatite. The obtained pellets preserved the mineralization potential of CaP@MSi and provided the prolonged 5-day DOX release. The obtained biphasic CaP@MSi composites seem to have an application potential as bone-specific drug delivery system.

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Section: In Vitro Mineralization Of Dox-30cap@msi Pelletssupporting

confidence: 56%

Section: Formulation Of Drug Delivery Systemsmentioning

confidence: 99%

Section: Dox Adsorption Onto the 30cap@msimentioning

confidence: 99%

Section: Dox Adsorption Onto the 30cap@msimentioning

confidence: 99%

See 2 more Smart Citations

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Prokopowicz

Szewczyk

Skwira

et al. 2019

Drug Deliv. and Transl. Res.

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“…Various methods of chemical drug release modification have been described [13][14][15][16]. They have been mainly focused on mesoporous silica surface functionalization by the reaction of silanols with the amino-propyl [17], carboxylic [18] groups, or organic chains [19,20]. These processes may slow down the release rate but usually the time of drug release does not exceed a few days [21,22].…”

Section: Introductionmentioning

confidence: 99%

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

et al. 2019

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Bone tissue inflammation, osteomyelitis, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against Staphylococcus aureus for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against Staphylococcus aureus (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against S. aureus and the highest cytocompatibility to human osteoblasts in vitro.

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Enantioseparation of racemic amlodipine using immobilized ionic liquid by solid‐phase extraction

Liu

Zhu

et al. 2020

Chirality

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In this paper, a novel l‐glutamate based immobilized chiral ionic liquid (SBA‐IL (Glu)) was prepared by chemical bonding method and applied as a solid sorbent for chiral separation of amlodipine. The performance of SBA‐IL (Glu) was investigated for the absorption of (S)‐amlodipine and separation of amlodipine enantiomer. The static experiment showed that equilibrium adsorption was achieved within 80 minutes, and the saturation adsorptions capacity was 12 mg/g. The complex was then packed in a glass chromatographic column for the separation of amlodipine and the enantiomeric excess (%ee) of (S)‐amlodipine reached 24.67%. The immobilized ionic liquids exhibit good reusability, and the separation efficiency remains 18.24% after reused five times, which allows potential scale‐up for the chiral separation of amlodipine.

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Aminopropyl-functionalized mesoporous silica SBA-15 as drug carrier for cefazolin: adsorption profiles, release studies, and mineralization potential

Cited by 44 publications

References 70 publications

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

Enantioseparation of racemic amlodipine using immobilized ionic liquid by solid‐phase extraction

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