Aminophylline for treatment of postdural puncture headache

Wu, Chuanjie; Guan, Dawei; Ren, Ming; Ma, Zhenzhen; Wan, Changming; Cui, Yinglin; Zhong, Ping; Zhao, Wenbo; Li, Chuanhui; Yan, Feng; Xie, Jinqiu; Xue, Fang; Lian, Yajun; Liu, Hongbo; Wang, Cui; Ji, Xunming; Xie, Ning

doi:10.1212/wnl.0000000000005351

Cited by 25 publications

(21 citation statements)

References 22 publications

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“…Some studies suggested that 250 mg of aminophylline can be effective in the treatment of PDPH without significant side-effects and it can be used in parturients without affecting lactation. 6,21 In this current study, no adverse reactions were observed in all pregnant women and infants. Therefore, the dosage of aminophylline used in the study was safe.…”

Section: Discussionsupporting

confidence: 43%

“…4,5 Recently, it was shown that oral or intravenous administration of theophylline or aminophylline can be effective in the treatment of PDPH, and that early treatment with aminophylline was more effective. 6 However, there have been no reports on the prevention and treatment of PDPH in patients after caesarean section. Therefore, the objective of this current study was to investigate the effect of aminophylline on the occurrence of PDPH in patients undergoing caesarean section under CSEA and to provide reference information for the clinical prevention of PDPH.…”

Section: Introductionmentioning

confidence: 99%

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Effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing caesarean section by combined spinal-epidural anaesthesia

Yang

Chen

et al. 2018

J Int Med Res

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Objective To investigate the effect of the pre-administration with aminophylline on the occurrence of post-dural puncture headache (PDPH) in women undergoing caesarean section by combined spinal-epidural anaesthesia (CSEA). Methods The study enrolled women undergoing elective caesarean sections with CSEA and randomly allocated them into two groups; for 30 min immediately after the infant was delivered, group A received 250 mg aminophylline intravenously and group B received an equal volume of normal saline. Demographic data, operation time, intraoperative blood loss, intraoperative transfusion volume and the occurrence of PDPH during the first 7 days after the operation were recorded. Side-effects such as hypersensitivity, convulsion and arrhythmia were also recorded in the patients and infants in group A within 24 h after aminophylline administration. Results A total of 120 patients aged 24–38 years (pregnancy range, 38–42 weeks) were randomly allocated into two groups ( n = 60). The incidence of PDPH in group A was significantly lower than group C (two of 59 [3.4%] versus 10 of 58 [17.2%], respectively). There were no related side-effects within 24 h after aminophylline administration in group A. Conclusions Intraoperative intravenous infusion of 250 mg aminophylline reduced the incidence of PDPH after caesarean section under CSEA with no side-effects.

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Section: Discussionsupporting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing caesarean section by combined spinal-epidural anaesthesia

Yang

Chen

et al. 2018

J Int Med Res

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“…Therapeutic measures with aminophylline and caffeine have been proven effective. 62 Notably, both substances elevate breathing frequency, which, considering it the main driving force, could result in more profound CSF being moved upward into the cranial vault.…”

Section: Spontaneous Intracranial Hypotension and Rhinoliquorrheamentioning

confidence: 99%

Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales

et al. 2021

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New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids: (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow–Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease.

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“…This therapeutic effect was already evident at the 30-minute time point and persisted for 2 days. There was no significant difference in the incidence of adverse events (18) .…”

Section: In Addition Chuanjie Et Al (2018)mentioning

confidence: 76%

Aminophylline Versus Acetaminophen in the Treatment of Post-Dural Puncture Headache

Fawaz

El-Gendy

Saleh

et al. 2021

Ain Shams Medical Journal

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Aminophylline for treatment of postdural puncture headache

Abstract: This study provides Class I evidence that for people with PDPH, IV aminophylline reduces headache severity.

Cited by 25 publications

References 22 publications

Effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing caesarean section by combined spinal-epidural anaesthesia

Effect of pre-administration with aminophylline on the occurrence of post-dural puncture headache in women undergoing caesarean section by combined spinal-epidural anaesthesia

Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales

Aminophylline Versus Acetaminophen in the Treatment of Post-Dural Puncture Headache

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