“…The Joint European Compound Library (JECL) is a key component of the European Lead Factory (ELF) [ 20 , 21 ] that holds drug-like and lead-like compounds for ELFâs screening facility [ 22 , 23 , 24 ]. In order to enrich this collection with small molecules rich in sp 3 features, chiral centers as well as drug-like molecular properties, different academic groups and small and medium enterprises (SMEs) are collaborating in library synthesis programs [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. With this perspective and along with our continuing interest in the synthesis of natural product inspired compound collections for biological studies [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ], we report here our synthesis efforts to build a compound library that is represented by six highly sp 3 -rich, novel and distinct hetero- and carbocyclic scaffolds that are found as core-structures in biologically active NPs, as depicted in Figure 1 .…”