“…The imino nitrogen appears also to be a very efficient nucleophilic center [37]. Despite the fact that 2-iminothiazolidin-4-one (3) has four nucleophilic reaction centers, viz., the two nitrogens (imino and amido), oxygen and C 5 atoms, its aminomethylation usually takes place only at the ring nitrogen atom [38,39] or, if it is substituted, at the exocylic nitrogen atom [40,41].…”