Die Umsetzung von 2‐Imino‐3‐aryl‐4‐oxo‐thiazolidinen (I) mit Formaldehyd (II) und den cyclischen Aminen (III) führt zu den Mannich‐Basen (IV) bzw. (VI).
The reaction of nucleophilic reagents with epoxides of the pyran series is a convenient method for the stereoselective synthesis of various functional derivatives of this class [1, 2], which are of interest as potential biologically active compounds. We have therefore investigated the reactions of 1,6-dioxaspiro[2.5]octane. (13 with a sgries of nucleophiles, viz. methanol, phenols, thiols, thiocyanic and 2,4-dichlorophenylacetic acids, sodium sulfite, and thiourea. Compound (I) was obtained by the oxidation of 4-methylenetetrahydropyran [1], a byproduct in the manufacture of isoprene by the dioxan method. MeOH RISH H202 _ : H + NaOI-I~--
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