Aminolated and Thiolated PEG‐Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A

Lin, Li‐Kai; Uzunoğlu, Aytekin; Stanciu, Lia

doi:10.1002/smll.201702828

Cited by 62 publications

(61 citation statements)

References 40 publications

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“…The GNP absorbance peak was observed at 530 nm; the absorbance peaks for the three sizes of GNSs were observed at 570, 580, and 610 nm; the absorbance peaks for the two sizes of GNCs were observed at 530 nm with slight differences; and the absorbance peaks for the three sizes of GNRs were observed at 530 and 560 nm for GNR (g), 520 and 600 nm for GNR (h), and 530 and 620 nm for GNR (i) since each GNR structure had two very different dimensions (Figure ). Further coupling and blocking steps were monitored and examined by absorbance spectra and zeta potential values as in our previously reported papers (not shown) …”

Section: Resultsmentioning

confidence: 99%

“…However, during experiments and manufacturing processes, the commonly used buffers contain NaCl and KCl. Such components drastically increase the ion concentration in solution and shrink the electrostatic double layers on the GNPs, resulting in instability, easy aggregation of GNPs and fluctuations in the LOD . Although there were some differences in LOD, the performances were still very coherent, and the tendencies of the systems were the same.…”

Section: Resultsmentioning

confidence: 99%

“…The LFA was first used to detect BPA in 2013. Conjugates of anti‐BPA antibodies with gold nanoparticles were used as recognition probes, and the LOD was 5 ng mL −1 (5 ppb) for visual observation …”

Section: Introductionmentioning

confidence: 99%

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Tuning a Bisphenol A Lateral Flow Assay Using Multiple Gold Nanosystems

Lin

Huang

Dutta

et al. 2019

Part & Part Syst Charact

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Advanced bisphenol A (BPA) lateral flow assays (LFAs) that use multiple nanosystems are reported. The assays use three nanosystems: gold nanostars, gold nanocubes, and gold nanorods, which are rarely applied in LFAs, compared with general gold nanoparticles that are referred to as gold nanospheres in this paper. These various nanosystems are bound to anti‐BPA antibodies and applied in LFAs to develop advanced BPA LFAs; the developed LFAs show differing BPA detection performance, as well as different visible colors, optical intensities, limits of detection, and application ranges. Advanced BPA LFAs that use multiple gold nano‐object shapes are successfully developed, and the geometry effects of diverse gold nanosystems coupled with anti‐BPA antibodies and the potential applications of regular BPA LFAs are explored.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Tuning a Bisphenol A Lateral Flow Assay Using Multiple Gold Nanosystems

Lin

Huang

Dutta

et al. 2019

Part & Part Syst Charact

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“…Lateral‐Flow Test Strip Fabrication : The nitrocellulose strips were fabricated according to Lin et al, with dimensions of 58 mm × 4 mm . Each part was overlapped by 3 mm to ensure sample transport between pads.…”

Section: Methodsmentioning

confidence: 99%

Inkjet Printed Nanopatterned Aptamer‐Based Sensors for Improved Optical Detection of Foodborne Pathogens

Díaz‐Amaya

Zhao

Lin

et al. 2019

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The increasing incidence of infectious outbreaks from contaminated food and water supply continues imposing a global burden for food safety, creating a market demand for on‐site, disposable, easy‐to‐use, and cost‐efficient devices. Despite of the rapid growth of biosensors field and the generation of breakthrough technologies, more than 80% of the platforms developed at lab‐scale never will get to meet the market. This work aims to provide a cost‐efficient, reliable, and repeatable approach for the detection of foodborne pathogens in real samples. For the first time an optimized inkjet printing platform is proposed taking advantage of a carefully controlled nanopatterning of novel carboxyl‐functionalized aptameric ink on a nitrocellulose substrate for the highly efficient detection of E. coli O157:H7 (25 colony forming units (CFU) mL−1 in pure culture and 233 CFU mL−1 in ground beef) demonstrating the ability to control the variation within ±1 SD for at least 75% of the data collected even at very low concentrations. From the best of the knowledge this work reports the lowest limit of detection of the state of the art for paper‐based optical detection of E. coli O157:H7, with enough evidence (p > 0.05) to prove its high specificity at genus, species, strain, and serotype level.

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“…Primarily, NPs require a stabilizing agent, such as cetyltrimethylammonium bromide (CTAB), citrate, and polyvinylpyrrolidone, to prevent aggregation in solution. If these stabilizing agents are disturbed by any chemical agent, aggregation of nanomaterial occurs.…”

Section: Fluorescence‐/colorimetric‐based Biosensorsmentioning

confidence: 99%

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

et al. 2019

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Label‐free biosensors offer accurate sensing capabilities due to the reliable quantification of biological and biochemical processes. These devices function by establishing a dynamic interaction of analyte and receptor molecules and convert this interaction into a measurable signal through a transducer. In recent decades, label‐free biosensors have attracted attention in biomedical applications due to the ease of linking nanomaterials with bioreceptor molecules. In this review, recent advances in sensitivity, specificity, and sensing mechanism related to label‐free biosensors of metallic nanoparticles of gold, silver, aluminium, copper, and zinc oxide are presented. Selected sensing methods based on fluorescence, surface plasmon resonance, surface‐enhanced Raman scattering, metal‐enhanced fluorescence, and electrochemical sensors are discussed. New measurement techniques and rapid progress of label‐free biosensors are going to play a vital role in the real‐time detection of biomarkers in clinical samples, such as blood plasma, serum, and urine, as well as in targeted drug delivery. Future trends of these label‐free biosensing mechanisms and their development are also discussed.

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Aminolated and Thiolated PEG‐Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A

Cited by 62 publications

References 40 publications

Tuning a Bisphenol A Lateral Flow Assay Using Multiple Gold Nanosystems

Tuning a Bisphenol A Lateral Flow Assay Using Multiple Gold Nanosystems

Inkjet Printed Nanopatterned Aptamer‐Based Sensors for Improved Optical Detection of Foodborne Pathogens

Strategies for the Development of Metallic‐Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications

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