Aminoglycosides and Aminocyclitols (Other Than Streptomycin)

Hotta, Kunimoto; Davies, Julian; Yagisawa, Morimasa

doi:10.1016/b978-0-7506-9095-9.50030-7

Cited by 7 publications

(1 citation statement)

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“…Antibiotic resistance in actinomycetes has been investigated from various perspectives such as self-resistance (Cundliffe, 1989 ; Demain, 1974 ), involvement in antibiotic biosynthesis (Piepersberg & Distler, 1997 ; Hotta et al, 1995 ), origin of clinical antibiotic resistance (Benveniste & Davies, 1973 ), and distribution among actinomycetes (Hotta et al, 1983a ). In the 1970s, the author and colleagues started investigations into the self-resistance of AG-producing Streptomyces strains (Hotta & Okami, 1976 ) and the screening of actinomycete isolates for plasmids since plasmid involvement in antibiotic biosynthesis was a leading topic at that time (Okanishi, 1979 ).…”

Section: Introductionmentioning

confidence: 99%

Basic and applied research on multiple aminoglycoside antibiotic resistance of actinomycetes: an old-timer's recollection

Hotta¹

2021

Journal of Industrial Microbiology and Biotechnology

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A list of our research achievements on multiple aminoglycoside antibiotic (AG) resistance in AG-producing actinomycetes is outlined. In 1979, the author discovered a novel AG (istamycin)-producing Streptomyces tenjimariensis SS-939 by screening actinomycetes with kanamycin (KM)-resistance and plasmid profiles. This discovery directed our biochemical and genetic approaches to multiple AG resistance (AGR) of AG producers. In this article, the following discoveries will be outlined: 1. AGR profiles correlating with the productivity of AGs in AG-producers, 2. Wide distribution of multiple AG resistance in AG-nonproducing actinomycetes, 3. Involvement of ribosomal resistance and AG-acetylating enzymes as underlying AGR factors, 4. Activation by single nucleotide substitution of a silent gene coding for aminoglycoside 3-N-acetyltransferase, AAC(3), in S. griseus, 5. Discovery of a novel antibiotic indolizomycin through protoplast fusion treatment between S. tenjimariensis and S. griseus strains with different AGR phenotypes and 6. Double stage-acting activity of arbekacin (ABK; an anti-MRSA semisynthetic AG) discovered by acetylation of ABK with cloned AACs; i.e. both ABK and its acetylated derivatives showed remarkable antibiotic activities.

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