“…Even though lots of rhodamine-based fluorescence probes have been widely applied in both solution and biosensing systems to discriminate the analytes from other biological abundant species so far, poor solubility of these probes in biological environments might result in decreased detection sensitivity, or even lose the response signal, which is a research bottleneck as regards progress in some areas of cell biology or medicine [55][56][57][58]. To increase the water solubility of the probes, several water soluble groups have also been introduced for intracellular pH measurements such as 1,2,3-triazole, hydroxyl and other methods [59][60][61][62].…”