A water-soluble pH fluorescence probe based on quaternary ammonium salt for bioanalytical applications

Zhao, Xuan-Xuan; Dai, Xi; Wu, Wen‐Li; Jiang, Miao; Zhao, Bao‐Xiang

doi:10.1016/j.saa.2015.06.111

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Cited by 15 publications

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“…6,7 The use of uorescent probes in biological research has increased, and the technique is now found in many applications. [8][9][10] Because of their high-accuracy and high-selectivity, and especially, non-radioactivity, uorescent probes may offer a more useful strategy for the diagnosis of tumors. 11,12 Cyclooxygenase-2 (COX-2) is an induced type of cyclooxygenase.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence imaging of hepatocellular carcinoma with a specific probe of COX-2

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Fluorescence imaging of hepatocellular carcinoma with a specific probe of COX-2

et al. 2018

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A Novel Water-soluble Ratiometric Fluorescent Probe Based on FRET for Sensing Lysosomal pH

et al. 2016

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A new ratiometric fluorescent probe based on Förster resonance energy transfer (FRET) for sensing lysosomal pH has been developed. The probe (RMPM) was composed of imidazo[1,5-α]pyridine quaternary ammonium salt fluorophore as the FRET donor and the rhodamine moiety as the FRET acceptor. It's the first time to report that imidazo[1,5-α]pyridine quaternary ammonium salt acts as the FRET donor. The ratio of fluorescence intensity of the probe at two wavelengths (I/I) changed significantly and responded linearly toward minor pH changes in the range of 5.4-6.6. It should be noted that it's rare to report that a ratiometric pH probe could detect so weak acidic pH with pKa = 6.31. In addition, probe RMPM exhibited excellent water-solubility, fast-response, all-right selectivity and brilliant reversibility. Moreover, RMPM has been successfully applied to sensing lysosomal pH in HeLa cells and has low cytotoxicity.

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