Amino acids level in rats upon long-term administration of progesterone

Abstract

Comparative study of embryo-fetal death in females fertilized by males with metabolic syndrome, induced in adult or juvenile age has shown that the offspring of adult rats did not have significant abnormalities in embrio-and fetogenesis. At the same time it has been revealed 4% postimplantation death of offspring in male rats with metabolic syndrome induced in the juvenile age. The pre-implantation loss in this group was 6 folds higher than in control. Accordingly, the total mortality of the offspring rose 2.4 times in comparison with control.Key words: metabolic syndrome, rats, embrio-and fetogenesis. AMINO ACIDSLEVELS IN RATS UNDER PROGESTERONE LONG-TERM ADMINISTRATIONAmino acids levels in blood serum of rats under progesterone long-term administration have been determined. The studies show that levels of most amino acids content decrease in rats under progesterone long-term administrationcompared with control group of rats. Obtained data give evidence that progesterone long-term administration significantly influence on amino acids metabolism.