Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice

Wu, Haibo; Liu, Fumin; Yang, Fan; Xiao, Yixin; Yao, Hang‐Ping; Wu, Nanping

doi:10.1016/j.rvsc.2020.03.017

Cited by 2 publications

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies have demonstrated how specific amino acid substitutions have led to changes in virulence and pathogenicity of the H7N7 virus. While the studies supporting these changes are few, they reveal a plausible pathway in which antigenic drift could lead to the evolution of novel AIVs with increased virulence or pathogenicity [ 49 , 50 , 51 , 52 , 53 , 54 ]. Yet, the evidence that supports these changes occurring naturally is lacking, possibly a product of diminished surveillance for this viral subtype.…”

Section: Amino Acid Substitutions In the Avian Influenza A (H7n7) Genome Can Increase Virulence And Pathogenicity In Humansmentioning

confidence: 99%

An Outbreak of Highly Pathogenic Avian Influenza (H7N7) in Australia and the Potential for Novel Influenza A Viruses to Emerge

Bisset

Hoyne

2021

Microorganisms

View full text Add to dashboard Cite

In 2020, several geographically isolated farms in Victoria, Australia, experienced an outbreak of highly pathogenic avian influenza (HPAI) virus H7N7 and low pathogenic avian influenza (LPAI) viruses H5N2 and H7N6. Effective containment and control measures ensured the eradication of these viruses but the event culminated in substantial loss of livestock and significant economic impact. The avian HPAI H7N7 virus generally does not infect humans; however, evidence shows the ocular pathway presents a favourable tissue tropism for human infection. Through antigenic drift, mutations in the H7N7 viral genome may increase virulence and pathogenicity in humans. The Victorian outbreak also detected LPAI H7N6 in emus at a commercial farm. Novel influenza A viruses can emerge by mixing different viral strains in a host susceptible to avian and human influenza strains. Studies show that emus are susceptible to infections from a wide range of influenza viral subtypes, including H5N1 and the pandemic H1N1. The emu’s internal organs and tissues express abundant cell surface sialic acid receptors that favour the attachment of avian and human influenza viruses, increasing the potential for internal genetic reassortment and the emergence of novel influenza A viruses. This review summarises the historical context of H7N7 in Australia, considers the potential for increased virulence and pathogenesis through mutations and draws attention to the emu as potentially an unrecognised viral mixing vessel.

show abstract

Section: Amino Acid Substitutions In the Avian Influenza A (H7n7) Genome Can Increase Virulence And Pathogenicity In Humansmentioning

confidence: 99%

An Outbreak of Highly Pathogenic Avian Influenza (H7N7) in Australia and the Potential for Novel Influenza A Viruses to Emerge

Bisset

Hoyne

2021

Microorganisms

View full text Add to dashboard Cite

show abstract

Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice

et al. 2022

View full text Add to dashboard Cite

Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice

Cited by 2 publications

References 19 publications

An Outbreak of Highly Pathogenic Avian Influenza (H7N7) in Australia and the Potential for Novel Influenza A Viruses to Emerge

An Outbreak of Highly Pathogenic Avian Influenza (H7N7) in Australia and the Potential for Novel Influenza A Viruses to Emerge

Rapid emergence of a PB2 D701N substitution during adaptation of an H9N2 avian influenza virus in mice

Contact Info

Product

Resources

About