“…The 399Arg>Gln is situated within the BRCT-1 region harboring the poly(ADP-ribose)polymerase-binding domain (Shen et al, 1998). A few previous studies reported that the 399Gln allele was associated with a higher level of DNA adducts and glycophorin A mutations (Lunn et al, 1999;Matullo et al, 2001a, b), increased sister chromatin exchange frequencies (Duell et al, 2000), or higher sensitivity to ionizing radiation and chemical mutagens (Hu et al, 2001;Wang et al, 2003a, b). However, conflicting results also exist, showing no association between the 399Arg>Gln polymorphism and DNA adduct levels (Matullo et al, 2001a, b;Palli et al, 2001).…”