Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation

Seibert, Marcel; Kurrle, Nina; Schnütgen, Frank

doi:10.1016/j.matbio.2021.01.001

Cited by 13 publications

(9 citation statements)

References 146 publications

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“…It acts on the surface of the lysosome in response to Ragulator‐Rag complex made of LAMTOR subunits, that regulate MAPK and mTOR complex. [ 122 ] The LAMTOR subunits forms a complex with Rag GTPase and V‐ATPase, located on lysosomes that signal the Rag proteins (RagA, RagB, RagC and RagD) to translocate mTORC1 to the site of activation by V‐ATPase. [ 123 ] The V‐ATPase‐Ragulator complex acts as a docking site for LKB1‐mediated AMPK activation by forming the V‐ATPase‐Ragulator‐AXIN/LKB1‐ AMPK complex to regulate catabolism and anabolism.…”

Section: Myrtenalmentioning

confidence: 99%

Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

Boopathy,

Roy,

Gopal

et al. 2023

J Biochem & Molecular Tox

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Colon cancer is a serious health problem across the globe with various dietary lifestyle modifications. It arises as an inflammation mediated crypts in the colon epithelial cells and undergoes uncontrolled cell division and proliferation. Bacterial enzymes contribute to a major outbreak in colon cancer development upon the release of toxic metabolites from the gut microflora. Pathogen associated molecular patterns and damage associated molecular patterns triggers the NLPR3 inflammasome pathways that releases pro‐inflammatory cytokines to induce cancer of the colon. Contributing to this, specific chemokines and receptor complexes attribute to cellular proliferation and metastasis. Bacterial enzymes synergistically attack the colon mucosa and degenerate the cellular integrity causing lysosomal discharge. These factors further instigate the Tol like receptors (TLRs) and Nod like receptors (NLRs) to promote angiogenesis and supply nutrients for the cancer cells. Myrtenal, a monoterpene, is gaining more importance in recent times and it is being widely utilized against many diseases such as cancers, neurodegenerative diseases and diabetes. Based on the research data's, the reviews focus on the anticancer property of myrtenal by emphasizing its therapeutic properties which downregulate the inflammasome pathways and other signalling pathways. Combination therapy is gaining more importance as they can target every variant in the cellular stress condition. Clinical studies with compounds like myrtenal of the monoterpenes family is provided with positive results which might open an effective anticancer drug therapy. This review highlights myrtenal and its biological potency as a cost effective drug for prevention and treatment of colon cancer.

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Section: Myrtenalmentioning

confidence: 99%

Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

Boopathy,

Roy,

Gopal

et al. 2023

J Biochem & Molecular Tox

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“…65 For example, mTORC1 directly controls the process of macroautophagy and is a key center for autophagy regulation. 66 Many lncRNAs regulate autophagy by directly or indirectly affecting AMPK and mTORC1. 67 For example, lncRNA C2dat2 promotes autophagy via the miR-30d-5p/ DDIT4/mTOR axis in cerebral ischemia-reperfusion injury and plays a protective role in cerebral cortical neuronal cells.…”

Section: Lncrna-mediated Regulation Of Autophagymentioning

confidence: 99%

“…Most of the regulatory pathways of macroautophagy focus on the target of rapamycin, TOR kinase 65 . For example, mTORC1 directly controls the process of macroautophagy and is a key center for autophagy regulation 66 . Many lncRNAs regulate autophagy by directly or indirectly affecting AMPK and mTORC1 67 .…”

Section: The Role Of Lncrna‐regulated Autophagy In Akimentioning

confidence: 99%

The role of LncRNA‐regulated autophagy in AKI

2023

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Acute kidney injury (AKI) is a complex clinical syndrome involving a series of pathophysiological processes regulated by multiple pathways at the molecular and cellular level. Long noncoding RNAs (lncRNAs) play an important role in the regulation of epigenetics, and their regulation of autophagy‐related genes in AKI has attracted increasing attention. However, the role of lncRNA‐regulated autophagy in AKI has not been fully elucidated. Evidence indicated that lncRNAs play regulatory roles in most factors that induce AKI. LncRNAs can regulate autophagy in AKI via a complex network of regulatory pathways to affect the development and prognosis of AKI. This article reviewed and analyzed the pathways of lncRNA regulation of autophagy in AKI in recent years. The results provide new ideas for further study of the pathophysiological process and targeted therapy for AKI.

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“… 13 Arginine is another essential amino acid that has recently been observed to play a role in intracellular mTORC1 localization and function in skeletal muscle. 30 , 31 , 32 , 33 In terms of indirect anabolic stimulation, arginine has also been observed to improve vasodilatory capacity (enhance nutrient delivery in skeletal muscle) and stimulate insulin release (also stimulating mTORC1 signaling). 30 , 31 , 32 , 33 …”

Section: Introductionmentioning

confidence: 99%

“… 30 , 31 , 32 , 33 In terms of indirect anabolic stimulation, arginine has also been observed to improve vasodilatory capacity (enhance nutrient delivery in skeletal muscle) and stimulate insulin release (also stimulating mTORC1 signaling). 30 , 31 , 32 , 33 …”

Section: Introductionmentioning

confidence: 99%

Post-operative protein supplementation following orthopaedic surgery: A systematic review

George,

Holderread,

Lambert

et al. 2024

Sports Medicine and Health Science

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Amino acid sensory complex proteins in mTORC1 and macroautophagy regulation

Cited by 13 publications

References 146 publications

Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

Potential molecular mechanisms of myrtenal against colon cancer: A systematic review

The role of LncRNA‐regulated autophagy in AKI

Post-operative protein supplementation following orthopaedic surgery: A systematic review

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