Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors

Kubota, Akio; Meguid, Michael M.; Hitch, David C.

doi:10.1002/1097-0142(19920501)69:9<2343::aid-cncr2820690924>3.0.co;2-s

Cited by 83 publications

(65 citation statements)

References 18 publications

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“…Taking under consideration the results from the study, prediction of tumour malignancy by assessment of sulphur-containing amino acids seems to be limited due to the fact that cysteine and cystine in serum were not evaluated. In opposition to the observations, the results of experimental studies on humans have shown that aromatic amino acid concentration increases in subjects suffering from neoplastic processes of the gastrointestinal tract, while BCAAs level decreases in such patients (13,17,31). Other data from research conducted on humans demonstrated changes in BCAAs concentration in patients with various neoplastic diseases, although total amino acid level was decreased (7,17,21).…”

Section: Discussionmentioning

confidence: 90%

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Brodzki

Szpetnar

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to determine serum free amino acid concentration in male dogs suffering from benign and malignant perianal tumours. Serum concentrations of cysteic acid, glutamic acid, glutamine, aspartic acid, glycine, γ-aminobutyric acid, tryptophan, methionine, arginine, taurine, threonine, tyrosine, alanine, valine, isoleucine, and leucine were significantly changed in dogs suffering from benign and/or malignant tumours when compared to the control group (P<0.05). Serum concentration of serine, phenylalanine, lysine and histidine was not influenced in dogs with neoplastic disease (P>0.05). The evaluation of serum free amino acid concentration, has shown that threonine, glutamic acid, alanine, valine, isoleucine, leucine, γ-aminobutyric acid, and glycine have the highest diagnostic and prognostic value in dogs suffering from benign and malignant perianal tumours. Highly diagnostic and prognostic value in relation to benign tumour growth was also found while evaluating branched chain and acidic groups of amino acids. Serine, phenylalanine, lysine, and histidine, as well as alkaline amino acids were proved not to have diagnostic and prognostic value in dogs with the tumours. Thus, the evaluation of free amino acid concentration may serve diagnostic purposes and help in tumour malignancy differentiation. The elaborated experimental model may be used in further studies on neoplastic disease development and monitoring of applied treatment efficiency.

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Section: Discussionmentioning

confidence: 90%

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Brodzki

Szpetnar

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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“…'Hydroxyproline' appears to be the hallmark for celiac disease and other malabsorption states [7]. Comparison of patients with head and neck cancers with controls have demonstrated significant differences (increased lysine and decreased arginine levels) [8][9][10][11]. The plasma amino acid profile in patients with potentially malignant disorders and collagen metabolic disorders like OSMF are less well defined.…”

Section: Introductionmentioning

confidence: 99%

Amino Acid Profile in Oral Submucous Fibrosis: A High Performance Liquid Chromatography (HPLC) Study

Goel

Chandrasekhar

Ramani

et al. 2014

JCDR

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Background: Collagen is a significant structural protein, the integrity of which is essential to be maintained for proper homeostasis. Oral submucous fibrosis (OSMF), being a collagen metabolic disorder, may be subject to changes in amino acid profiling.Aim: The present study was attempted to evaluate the amino acid profile to assess its feasibility as a biological marker in OSMF. Materials and Methods:The study group comprised of 13 patents with OSMF and the normal group comprised of 13 normal patients without associated habits or systemic disorders. Venous blood was collected from the antecubital vein, plasma was separated and the plasma was then subjected to high profile liquid chromatographic analysis.

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“…They suggested that seven amino acids (glutamine, threonine, histidine, cysteine, alanine, arginine and ornithine) had a close link with specific cancers, indicating that PFAA profiles correlate with the organ-site origin among the three different malignant tumours. [13] Another study has found significant increases of ornithine, glutamic acid and free tryptophan levels in breast cancer patients. They came to the conclusion that the effects of the tumors on the host's PFAA profile depend on cancer type.…”

Section: Discussionmentioning

confidence: 99%

“…It has been proposed that the possibility of some cancers can induce characteristic plasma free amino acid profiles may suggest the roles of amino acids in diagnosing and finding the site of the cancer. [13,15] On the other hand, in the present literature, there is no report on the breast cyst fluid free amino acid profile, except one which reports the cystic concentrations of homocysteine, cysteine, cysteinylglycine and glutathione. [16] The importance of amino acids in cancer metabolism, and a relatively higher risk of developing breast carcinoma especially from the low electrolyte ratio breast cyst group together, led us to perform this study.…”

Section: Introductionmentioning

confidence: 97%

“…[9] There have been reports focused on the role of the plasma amino acid profile as a marker of cancer-linked protein metabolism alterations. [10][11][12][13][14] The description of different plasma amino acid profiles for specific types of cancer, such as the small cell lung cancer [11] and the hepatocellular carcinoma in patients with cirrhosis, [12] suggest that the metabolic alterations of each type of tumour determine their own, distinctive profile of plasma amino acids. It has been proposed that the possibility of some cancers can induce characteristic plasma free amino acid profiles may suggest the roles of amino acids in diagnosing and finding the site of the cancer.…”

Section: Introductionmentioning

confidence: 99%

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Breast Cyst Fluid Free Amino Acid Profile

Dağlar¹,

Erbas²,

Gülen³

2009

TUTFD

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© Trakya Üniversitesi T p Fakültesi Dergisi. AVES Yay nc l k taraf ndan bas lm t r. Her hakk sakl d r. © Medical Journal of Trakya University. Published by AVES Publishing. All rights reserved. Breast Cyst Fluid Free Amino Acid ProfileMeme Kist S v Objective: Gross cystic breast disease (GCBD) is the most common benign breast disease. There are two types of breast cyst; lined by apocrine epithelium (Na/ K<3) or flattened epithelium (Na/K>3). Several studies have shown that women with palpable breast cysts may have 1.7-7.5 times higher risk of developing breast cancer. Patients with malignant disease usually show abnormal amino acid profiles in the peripheral circulation. Changes in amino acid profile diagnostically correlate with organ sites of malignancy. The aim of this study was to investigate the levels of amino acids in two cyst groups and possible mechanisms involved in the development of breast cancer. Material and Methods:The breast cyst fluid aspirated from women with GCBD were analysed. Breast cyst fluid amino acid levels were determined with HPLC.Results: Aspartic acid, glutamic acid, hydroxyproline, serine, glycine, threonine, alanine, proline, tyrosine, methionine, isoleucine, leucine, phenylalanine and tryptophan levels were significantly higher, and lysine levels were lower in the apocrine epithelial cysts. Conclusion:In this study, higher concentrations of amino acids in apocrine cysts, which are also known to have a higher risk of developing breast cancer, may indicate the possible role(s) of amino acids in the mechanism of breast cancer development.Key words: Breast cyst fluid; gross cystic breast disease (GCBD); breast cancer; free amino acids; HPLC.Amaç: Kistik meme hastal klar kad nlarda en fazla görülen meme hastal d r. Apokrin epitelli (Na/K<3) ve düz epitelli (Na/K>3) olmak üzere iki tip meme kisti bulunmaktad r. Yap lan çe itli çal malar memesinde kistik bir olu um bulunan kad nlar n 1.7-7.5 kat daha fazla meme kanserine yakalanma riski ta d klar n ortaya koymu tur. Kanserli hastalar n periferal dola m na bak ld nda ise genellikle anormal bir amino asit profili saptanm t r. Ayr ca, amino asit profilindeki de i iklikler organ düzeyindeki kanserler ile ili kili bulunmu tur. Bu çal man n amac meme kanseri geli imi yönünden yüksek ve dü ük risk grubu kistlerdeki amino asit düzey-lerini incelemek ve bu kistlerden meme kanseri geli imi yönündeki olas mekanizmalar ara t rmakt r. Gereç ve Yöntemler:Çal mada kistik meme hastal olan kad nlardan al nan meme kist s v s kullan ld . Meme kist s v s amino asit düzeyleri HPLC metodu ile ölçüldü. Bulgular: Apokrin epitelli kist grubunda aspartik asit, glutamik asit, hidroksiprolin, serin, glisin, treonin, alanin, prolin, tirozin, metiyonin, izolösin, fenilalanin ve triptofan düzeyleri anlaml olarak yüksek, lizin düzeyi ise dü ük bulundu.Sonuç: Kanser geli imi yönünden yüksek riske sahip olan apokrin epitelli kistlerde bulunan daha yüksek amino asit düzeyleri, amino asitlerin meme kanseri geli im sürecinde potansiyel bir role sahip olabilece ini gösterm...

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Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors

Cited by 83 publications

References 18 publications

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Serum Concentration of Free Amino Acids in Dogs Suffering From Perianal Tumours

Amino Acid Profile in Oral Submucous Fibrosis: A High Performance Liquid Chromatography (HPLC) Study

Breast Cyst Fluid Free Amino Acid Profile

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