Amino acid metabolism: challenges and opportunities for the therapeutic treatment of leukemia and lymphoma

Liao, Peiyun; Chang, Ning; Xu, Binyan; Yu-chang, Qiu; Wang, Sheng; Zhou, Lijuan; He, Yanjie; Xie, Xiaoling; Li, Yuhua

doi:10.1111/imcb.12557

Cited by 8 publications

(6 citation statements)

References 189 publications

(583 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, TCR-and CD28-mediated signaling and cytokine receptor signaling are very crucial for proper T-cell activation and proliferation. Cytokines like IL-2 and IL-7 are wellestablished mediators of T-cell lymphoma metabolic reprogramming (38,60,277). Alternation in downstream signaling of cytokine receptors has been reported in various types of T-cell lymphomas, which has been discussed in the various sections of the review.…”

Section: Discussionmentioning

confidence: 99%

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Yadav,

Uikey,

Rathore

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

T cells are an important component of adaptive immunity and T-cell-derived lymphomas are very complex due to many functional sub-types and functional elasticity of T-cells. As with other tumors, tissues specific factors are crucial in the development of T-cell lymphomas. In addition to neoplastic cells, T- cell lymphomas consist of a tumor micro-environment composed of normal cells and stroma. Numerous studies established the qualitative and quantitative differences between the tumor microenvironment and normal cell surroundings. Interaction between the various component of the tumor microenvironment is crucial since tumor cells can change the microenvironment and vice versa. In normal T-cell development, T-cells must respond to various stimulants deferentially and during these courses of adaptation. T-cells undergo various metabolic alterations. From the stage of quiescence to attention of fully active form T-cells undergoes various stage in terms of metabolic activity. Predominantly quiescent T-cells have ATP-generating metabolism while during the proliferative stage, their metabolism tilted towards the growth-promoting pathways. In addition to this, a functionally different subset of T-cells requires to activate the different metabolic pathways, and consequently, this regulation of the metabolic pathway control activation and function of T-cells. So, it is obvious that dynamic, and well-regulated metabolic pathways are important for the normal functioning of T-cells and their interaction with the microenvironment. There are various cell signaling mechanisms of metabolism are involved in this regulation and more and more studies have suggested the involvement of additional signaling in the development of the overall metabolic phenotype of T cells. These important signaling mediators include cytokines and hormones. The impact and role of these mediators especially the cytokines on the interplay between T-cell metabolism and the interaction of T-cells with their micro-environments in the context of T-cells lymphomas are discussed in this review article.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Yadav,

Uikey,

Rathore

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Amino acid metabolism inhibitors: Immune cell function can be improved by inhibiting enzymes involved in amino acid metabolism, such as IDO or arginase. IDO inhibitors, such as epacadostat, and arginase inhibitors, such as nor‐NOHA, can enhance T cell responses 88,89 …”

Section: Strategies For Enhancing Immune Responsementioning

confidence: 99%

Discovering the strength of immunometabolism in cancer therapy: Employing metabolic pathways to enhance immune responses

Huldani,

Malviya,

Rodrigues

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

Immunometabolism, which studies cellular metabolism and immune cell function, is a possible cancer treatment. Metabolic pathways regulate immune cell activation, differentiation, and effector functions, crucial to tumor identification and elimination. Immune evasion and tumor growth can result from tumor microenvironment metabolic dysregulation. These metabolic pathways can boost antitumor immunity. This overview discusses immune cell metabolism, including glycolysis, oxidative phosphorylation, amino acid, and lipid metabolism. Amino acid and lipid metabolic manipulations may improve immune cell activity and antitumor immunity. Combination therapy using immunometabolism‐based strategies may enhance therapeutic efficacy. The complexity of the metabolic network, biomarker development, challenges, and future approaches are all covered, along with a summary of case studies demonstrating the effectiveness of immunometabolism‐based therapy. Metabolomics, stable isotope tracing, single‐cell analysis, and computational modeling are also reviewed for immunometabolism research. Personalized and combination treatments are considered. This review adds to immunometabolism expertise and sheds light on metabolic treatments' ability to boost cancer treatment immunological response. Also, in this review, we discussed the immune response in cancer treatment and altering metabolic pathways to increase the immune response against malignancies.

show abstract

“…AhR is a very important transcription factor involved in the metabolism of drugs, dioxins, and other xenobiotics in the cytochrome P450 complex [ 71 , 72 , 73 ]. Tryptophan catabolism in the kynurenine pathway is directly catalyzed by the rate-limiting enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase [ 74 , 75 ]. Sun et al investigated the expression and function of IDO1 in AML and ALL cells in mice.…”

Section: Postbiotic In Allmentioning

confidence: 99%

Prevention and Health Benefits of Prebiotics, Probiotics and Postbiotics in Acute Lymphoblastic Leukemia

et al. 2023

View full text Add to dashboard Cite

Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children, comprising 75–85% of cases. Aggressive treatment of leukemias includes chemotherapy and antibiotics that often disrupt the host microbiota. Additionally, the gut microbiota may play a role in the development and progression of acute leukemia. Prebiotics, probiotics, and postbiotics are considered beneficial to health. The role of prebiotics in the treatment and development of leukemia is not well understood, but inulin can be potentially used in the treatment of leukemia. Some probiotic bacteria such as Lactobacillus shows anticancer activity in in vitro studies. Additionally, Bifidobacterium spp., as a consequence of the inhibition of growth factor signaling and mitochondrial-mediated apoptosis, decrease the proliferation of cancer cells. Many bacterial metabolites have promising anticancer potential. The available research results are promising. However, more research is needed in humans, especially in the child population, to fully understand the relationship between the gut microbiota and acute leukemia.

show abstract

Amino acid metabolism: challenges and opportunities for the therapeutic treatment of leukemia and lymphoma

Cited by 8 publications

References 189 publications

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Role of cytokine in malignant T-cell metabolism and subsequent alternation in T-cell tumor microenvironment

Discovering the strength of immunometabolism in cancer therapy: Employing metabolic pathways to enhance immune responses

Prevention and Health Benefits of Prebiotics, Probiotics and Postbiotics in Acute Lymphoblastic Leukemia

Contact Info

Product

Resources

About