Amino acid incorporation in cell cultures from eyes with pseudo‐exfoliation material

Nicolaissen, Bjørn; Ringvold, Amund; Næss, Oddvar

doi:10.1111/j.1755-3768.1992.tb08582.x

Cited by 5 publications

(2 citation statements)

References 14 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histochemically, PE material contains both protein and glycosaminoglycans (Morrison & Green 1988; Hietanen & Tarkkanen 1989; Hietanen et al. 1994) and is found even after 1 month in cell culture; however, metabolic studies on the incorporation of amino acids into proteins have failed to disclose differences between normal and PE tissue in vitro (Nicolaissen et al. 1992).…”

Section: Introductionmentioning

confidence: 99%

Cataract and glaucoma surgery in pseudoexfoliation syndrome: a review

Drolsum

Ringvold

Nicolaissen

2007

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

ABSTRACT. Pseudoexfoliation syndrome is a risk factor in cataract surgery because of the increased weakness of zonular apparatus and reduced pupillary dilatation. The surgical outcome of using phacoemulsification in the central zone, inducing minimal stress on the zonules, inserting a capsular tension ring in selected cases, and stretching the pupil mechanically in eyes with miotic pupils, may turn out to be uneventful in most cases. Postoperative fibrosis with subsequent shrinkage of the capsule is increased in these eyes, and these centripetal forces will further loosen the zonular fibres. Late in-the-bag intraocular lens dislocation is therefore anticipated to become a growing problem in the future. Despite the dysfunctioning of the blood-aqueous barrier in eyes with pseudoexfoliation syndrome, the frequency of postoperative inflammatory reaction is low due to the improvements made in surgical technique and equipment in recent years. Glaucoma frequently occurs in eyes with pseudoexfoliation syndrome. Compared with primary open-angle glaucoma, optic damage is more pronounced in these eyes at the time of diagnosis and response to medical therapy is poorer. Although responses to argon laser therapy and filtering surgery are roughly similar between the two types of glaucoma, there are indications that primary laser trabeculoplasty has a higher success rate in pseudoexfoliation glaucoma than in primary open-angle glaucoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Cataract and glaucoma surgery in pseudoexfoliation syndrome: a review

Drolsum

Ringvold

Nicolaissen

2007

Acta Ophthalmologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…τη βασική µεµβράνη των κυττάρων, µε τελικό αποτέλεσµα την εκφύλιση των ίδιων των κυττάρων.Κατά συνέπεια, µια ποικιλία επιθηλιακών και µεσεγχυµατικών κυττάρων έχουν κοινή µεταβολική βλάβη, µε αποτέλεσµα την υπερβολική σύνθεση εξωκυττάριων ινιδίων. Αν και η γλυκοπρωτεΐνη θροµβοσπονδίνη-1 δεν µπορεί να ανευρεθεί στο ΥΑ, ινοβλάστες της ίριδας και του στρώµατος του κερατοειδούς βρέθηκε ότι εκκρίνουν αυτό το µόριο σε άτοµα µε ΣΑ, καταδεικνύοντας ότι οι ινοβλάστες σε άτοµα µε ΣΑ έχουν µετάπλαση στο µοριακό τους προφίλ362 . βιοχηµικές και ανοσοϊστοχηµικές µελέτες της σύστασης του ΥΑ οδήγησαν στη διατύπωση των ακολούθων θεωριών σχετικά µε την παθοφυσιολογία του ΣΑ: Σε µια µελέτη σε Σουηδούς ασθενείς βρέθηκε υψηλότερη συχνότητα του αντιγόνου HLA Bw35 στο ΓΑ απ' ότι στους µάρτυρες99 , αλλά το εύρηµα αυτό δεν επιβεβαιώθηκε.…”

unclassified