Amino Acid-Hypertonic Glucose Treatment for Intractable Diarrhea in Infants

Endogenous Amino Acid Loss and Its Significance in Infantile Diarrhea

“…Total parenteral alimentation provides such an approach, and its effectiveness in the cure of intractable diarrhea has been documented recently in an increasing number of reports [5,6,10,14,25,28]. Table IV summarizes pub- lished data on 22 infants with protracted diarrhea who were treated by total parenteral alimentation.…”

Advances in Infant Nutrition over the Past Quarter Century

“…Thereafter, others described the feasibility of this technique in promoting growth and development of infants undergoing a number of surgical procedures for correction of congenital or acquired lesions of the gastrointestinal tract [2] and infants with chronic diarrhea [3]. Although a controlled trial was never conducted, it is apparent that this therapy is largely responsible for improving survival of both types of patients [4], from approximately 25% prior to the ad vent of total parenteral nutrition to more than 90% today.…”

Presentation of the Distinguished Service Award to Dr. James P. Keating

“…As Director of the Division of Pediatric Gastroenterology and Nutrition in the Department of Pediatrics at Washington University School of Medicine, Dr. Keating introduced parenteral nutrition therapy to St. Louis Children's Hospital. He published one of the first three articles describing the rationale and success of this therapy and then expanded the series to over 100 infants and children (1,2). The safety and efficacy of parenteral nutrition were clearly established.…”