Amino acid disorders

Aliu, Ermal; Kanungo, Shibani; Arnold, Georgianne L.

doi:10.21037/atm.2018.12.12

Cited by 93 publications

(64 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With increasing national income and advancements in poultry production and genetics, the national rate of chicken breast consumption has increased as a desired dietary protein source providing all 9 essential amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine) required in the human diet ( USDA, 2015 ; Aliu et al., 2018 ). The essential amino acids are required in the diet to maintain vital physiological functions and cannot be produced de novo .…”

Section: Resultsmentioning

confidence: 99%

Feeding high-oleic peanuts to meat-type broiler chickens enhances the fatty acid profile of the meat produced

et al. 2020

View full text Add to dashboard Cite

Early feeding trials using peanut meal prepared from normal-oleic peanuts helped to identify peanuts as a suitable alternative feed ingredient for poultry. Yet no studies to date have examined the use of high-oleic peanuts ( HO-PN ) as a feed ingredient for meat type chickens. Therefore, this study aimed to determine the effect of feeding whole unblanched HO-PN on the fatty acid profile of the meat produced from broilers. At hatch male chicks were randomly placed in raised wire cages, in 10 replicate pens per treatment with 10 chicks per pen, and fed with one of the 3 isocaloric, isonitrogenous diets ad libitum for 42 days: (1) conventional control of soybean meal + corn, (2) 10 to 12% HO-PN and corn diet, or (3) control diet spiked with ≈6.0% oleic acid oil. All body weights ( BW ) were collected, and broiler selection for processing was determined by individual BW within one-half a standard deviation of the experiment 42-D mean BW, with one bird selected per pen (10 replicate pens per treatment, 3 treatments, 10 birds selected per treatment, yielding a total sample size of 30 birds). Performance was determined weekly and breast samples were analyzed for fatty acid and amino acid profile. All data was analyzed using analysis of variance, with t-test mean comparisons at P < 0.05. BW were similar between broilers fed the HO-PN and control diet, while feed conversion ratio of broilers fed the HO-PN diet was significantly higher at weeks 2, 4, and 6 in comparison to the other treatments ( P ≤ 0.03). Broilers fed with HO-PN diet had reduced carcass and pectoralis major weights in comparison to the other treatments. Chicken breast from broilers fed the HO-PN diet had significantly reduced saturated and trans fatty acid content in comparison to the controls ( P ≤ 0.0002). Although additional studies must be conducted, this study suggests that feeding whole unblanched HO-PN to broiler chickens may serve as a means to enrich the meat produced with unsaturated fatty acids.

show abstract

Section: Resultsmentioning

confidence: 99%

Feeding high-oleic peanuts to meat-type broiler chickens enhances the fatty acid profile of the meat produced

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Glutamate, methionine, glycine, isoleucine, leucine, lysine, and phenylalanine were found in significantly lower concentrations in severe hypospadias. These metabolites are associated with inborn errors of metabolism (32)(33)(34)(35)(36)(37)(38). Some examples of inborn errors of metabolism diseases are phenylketonuria, maple syrup urine disease, tyrosinemia type I, glycine encephalopathy, which involve the deficiency or accumulation of these amino acids (32).…”

Section: Discussionmentioning

confidence: 99%

“…These metabolites are associated with inborn errors of metabolism (32)(33)(34)(35)(36)(37)(38). Some examples of inborn errors of metabolism diseases are phenylketonuria, maple syrup urine disease, tyrosinemia type I, glycine encephalopathy, which involve the deficiency or accumulation of these amino acids (32). Moreover, Carmichael and colleagues (38) investigated whether hypospadias is associated with maternal dietary intake of nutrients related to one-carbon metabolism, including methionine.…”

Section: Discussionmentioning

confidence: 99%

Severity-Dependent Profile of the Metabolome in Hypospadias

et al. 2020

View full text Add to dashboard Cite

Background & Objective: Hypospadias, characterized by the displacement of the opening of the urethra at any point in the medial-ventral side of the penis, is classified upon severity as mild (Type I) and severe (Type II and Type III) hypospadias. Hypospadias' etiology is idiopathic in the majority of cases, and underlying causes seem of multifactorial origin. Studies regarding genetic variants support this notion. It is unknown whether downstream gene products fit this profile. This study evaluated the metabolome of hypospadias by using the emerging technology of metabolomics in the search for distinct cellular processes associated with hypospadias' etiology according to the severity of this congenital urogenital condition. Methods: Foreskin samples were collected during urethroplasty from boys with Type I, II, and III hypospadias or undergoing elective circumcision (N = 28) between 5 and 28 months of age. Samples were processed and submitted to gas chromatography-mass spectrometry (GC/MS). MetaboloAnalyst (http://www.metaboanalyst.ca/) online platform was used for bioinformatic analyses. Results: Thirty-five metabolites across experimental groups were identified by GC/MS. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) showed that the metabolome of Type II and Type III hypospadias patients differs from the metabolome of Type I hypospadias and control patients. Of those 35, 10 amino acids were found in significantly low concentrations in severe hypospadias: aspartate, glutamate, glycine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, and tyrosine. A high concentration of the amino acid lysine was detected in mild hypospadias. Conclusions: The observed downregulation of specific amino acids in severe hypospadias provides alternative routes for future research aiming to identify disrupted networks and pathways while considering the severity of hypospadias.

show abstract

“…Moreover, a high reduction of 2-hydroxyisovalerate and 2-hydroxyisocaproate concentrations after the ulcer treatment with probiotics was also detected. These molecules are hydroxyderivate of the alpha-ketoacid catabolites respectively produced by transamination of valine and leucine [38, 39]. Valine and leucine catabolism may proceed toward propionate synthesis or may shift to 2-hydroxyisovalerate and 2-hydroxyisocaproate production.…”

Section: Discussionmentioning

confidence: 99%

Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy

Venosi

Ceccarelli²,

Angelis³

et al. 2019

J Transl Med

View full text Add to dashboard Cite

BackgroundA wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor.Aim: clinical reportAn 83-year-old woman suffering a critical limb ischemia and an infected difficult-to-treat ulcerated cutaneous lesion of the right leg, was complementary treated with local application of a mixture of probiotic bacteria.MethodsMicrobiological and metabolomic analysis were conducted on wound swabs obtained before and after bacteriotherapy.ResultsDuring the treatment course, a progressive healing of the lesion was observed with microbiological resolution of the polymicrobial infection of the wound. Metabolomic analysis showed a significant difference in the local concentration of propionate, 2-hydroxyisovalerate, 2-oxoisocaproate, 2,3-butanediol, putrescine, thymine, and trimethylamine before and after bacteriotherapy.ConclusionThe microbiological and metabolomic results seem to confirm the usefulness of complementary probiotic treatment in difficult-to-treat infected wounds. Further investigations are needed to confirm these preliminary findings.

show abstract

Amino acid disorders

Cited by 93 publications

References 20 publications

Feeding high-oleic peanuts to meat-type broiler chickens enhances the fatty acid profile of the meat produced

Feeding high-oleic peanuts to meat-type broiler chickens enhances the fatty acid profile of the meat produced

Severity-Dependent Profile of the Metabolome in Hypospadias

Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy

Contact Info

Product

Resources

About