Amino acid containing amorphous calcium phosphates and the rapid transformation into apatite

Ikawa, Nobuaki; Kimura, Takaumi; Oumi, Yasunori; Sano, Tsuneji

doi:10.1039/b815154g

Cited by 53 publications

(38 citation statements)

References 42 publications

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“…This order agrees with that deduced from equation (2). Ikawa et al reported the synthesis of amino acid-containing amorphous calcium phosphates and further converted these amorphous calcium phosphates to crystalline apatite by immersion in a simulated body fluid [41]. In this method, glutamic acid (Glu), aspartic acid (Asp) and lysine (Lys) were added to the synthesis reaction of calcium phosphate, and the pHs of the amino acid-containing systems were all different.…”

Section: Resultsmentioning

confidence: 99%

Block-copolymer-assisted synthesis of hydroxyapatite nanoparticles with high surface area and uniform size

Huang

Imura

Nemoto

et al. 2011

Science and Technology of Advanced Materials

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We report the synthesis of hydroxyapatite nanoparticles (HANPs) by the coprecipitation method using calcium D-gluconate and potassium hydrogen phosphate as the sources of calcium and phosphate ions, respectively, and the triblock copolymer F127 as a stabilizer. The HANPs were characterized using scanning electron microscopy, x-ray diffraction, and nitrogen adsorption/desorption isotherms. Removal of F127 by solvent extraction or calcination alters the structure of HANPs. The solvent-extracted HANPs were single crystals with their 001 axis oriented along the rod axis of the HANP, whereas the calcined HANPs contained two crystal phases that resulted in a spherical morphology. The calcined HANPs had much higher surface area (127 m 2 g −1 ) than the solvent-extracted HANPs (44 m 2 g −1 ).

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Section: Resultsmentioning

confidence: 99%

Block-copolymer-assisted synthesis of hydroxyapatite nanoparticles with high surface area and uniform size

Huang

Imura

Nemoto

et al. 2011

Science and Technology of Advanced Materials

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“…The drug can be introduced either in the liquid or the solid phase of the CPC, but care must be taken that the physicochemical properties of the drug or protein do not change during the chemical reaction and setting of CPC. Different kinds of drugs, including antibiotics [184–186], anticancer agents [103], growth factors [17], proteins/amino acids [18,19], and antimicrobial peptides (AMPs) [187,188], have been incorporated into CPCs for various applications.…”

Section: Calcium Phosphate Cement (Cpc)mentioning

confidence: 99%

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

2012

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Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their application. CaPs are more biocompatible than many other ceramic and inorganic nanoparticles. Their biocompatibility and variable stoichiometry, thus surface charge density, functionality, and dissolution properties, make them suitable for both drug and growth factor delivery. CaP matrices and scaffolds have been reported to act as delivery vehicles for growth factors and drugs in bone tissue engineering. Local drug delivery in musculoskeletal disorder treatments can address some of the critical issues more effectively and efficiently than the systemic delivery. CaPs are used as coatings on metallic implants, CaP cements, and custom designed scaffolds to treat musculoskeletal disorders. This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.

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“…At neutral pH, anionic organic macromolecules such as proteins show a considerably greater influence on HAP crystallization than do positive or neutral species, suggesting that they bind to the CaP nanoclusters; this is especially the case for proteins with a hydrophilic carboxylate head that can significantly shorten the induction time of OCP [15] or HAP [16,17], and promote the formation of the corresponding crystals. Small amino acids can also promote rapid transformation of amorphous CaPs into apatite [18]. However, some aspartic-acid-rich proteins and peptides could significantly inhibit the formation of calcium-based minerals [19][20][21][22][23].…”

Section: Nucleation and Growth Of Calcium Orthophosphate Crystals Fromentioning

confidence: 99%

Dynamics of crystallization and dissolution of calcium orthophosphates at the near-molecular level

Wang

et al. 2011

Chin. Sci. Bull.

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Although extensive investigations of biogenic and geological calcium phosphate crystallization/dissolution and their phase transformations have been performed, the mechanisms of crystallization and dissolution of sparingly soluble calcium phosphates in geological settings have not been completely determined at the near-molecular level. In particular, an understanding of the physical-chemical processes at the earliest nucleation stage and the subsequent crystal surface dynamics in soil solutions is lacking. This review focuses on the earliest events in homo/heterogeneous nucleation from an initial supersaturated solution phase, the subsequent growth of calcium phosphate phases, and the relevant influences of the presence of additional inorganic and organic molecules in both geological and biological settings. These studies have implications for the understanding of the complex processes of calcium phosphate transformations in soils, and provide possible physical-chemical mechanisms for the biogeochemical behavior of phosphorus at the near-molecular level. calcium orthophosphates, crystallization, dissolution, AFM Citation:Wang L J, Lu J W, Xu F S, et al. Dynamics of crystallization and dissolution of calcium orthophosphates at the near-molecular level.

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Amino acid containing amorphous calcium phosphates and the rapid transformation into apatite

Cited by 53 publications

References 42 publications

Block-copolymer-assisted synthesis of hydroxyapatite nanoparticles with high surface area and uniform size

Block-copolymer-assisted synthesis of hydroxyapatite nanoparticles with high surface area and uniform size

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

Dynamics of crystallization and dissolution of calcium orthophosphates at the near-molecular level

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