Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study

Moety, Ghada Abdel Fattah Abdel; Ali, Ahmed M.; Fouad, Reham; Ramadan, Wafaa; Belal, Doaa S.; Haggag, Hisham

doi:10.1016/j.ejogrb.2017.01.003

Cited by 20 publications

(20 citation statements)

References 10 publications

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“…These results agree with the results of Abdel Moety et al [8] who have shown that at the end of 12 weeks of treatment, the cure rate (percentage of women who reached the WHO hemoglobin target of 11g/dL) was not significantly different between both groups. This means that from the therapeutic point of view, both IAAC and FF corrected iron deficiency anemia accompanying pregnancy.…”

Section: Discussionsupporting

confidence: 92%

“…Amino acid chelated iron therapy was reported to have more rapid effect with less GIT side effects [8] and this is what we want to prove in this study.…”

Section: Introductionmentioning

confidence: 53%

“…Oral iron preparations for the correction of iron deficiency include iron salts, iron chelates and ferric hydroxide complexes [8] . Ferrous salts are characterized by a variable absorption rate [12] .…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported that after 4 weeks, the hemoglobin level increased by 0.77 ± 0.43 g/dl versus 0.31 ± 0.31 g/dl in patients receiving IAAC or FF, respectively. After 8 weeks, the hemoglobin level increased by 1.51 ± 0.61 g/dl versus 0.64 ± 0.51 g/dl and after 12 weeks, the hemoglobin level increased by 1.6 ± 0.6 g/dl versus 1.32 ± 0.55 g/ dl, respectively [8] . So, it is estimated that a sample size of 68 patients in either study group was had a power of 80% to detect a statistically significant difference of 0.28 g/dl between the 2 groups as regards the increase in hemoglobin at 12 weeks (corresponding to means of 1.6 versus 1.32 g/dl) with assumed common SD of 0.58 g/dl (based on SD estimates of 0.60 and 0.55).…”

Section: Sample Size Justificationmentioning

confidence: 91%

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Amino Acid Chelated Iron versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia with Pregnancy : Randomized Controlled Trial

Makled

Abuelghar

El-Shahawy

et al. 2020

Evidence Based Women's Health Journal

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Background: Anemia is a major health problem. Iron deficiency is the most common cause of anemia during pregnancy. Suboptimal iron content in the average mother's diet and the presence of insufficient iron stores during the reproductive years are causes for this predominance. In many developing countries, iron deficiency anemia (IDA) in pregnancy is more of a rule than an exception with a prevalence of 52%. In the Western societies, the frequency of IDA is approximately 25% in pregnant women not taking iron supplements and less than 5% in women taking iron supplements. Anemia has a significant impact on the health of the fetus and the mother. It can be associated with increased preterm labour, preeclampsia, and maternal sepsis. It can also lead to fetal loss or even perinatal deaths. Aim: To find out whether there is a difference between amino acid chelated iron and iron salts (ferrous fumarate) in effect, safety, adverse effects and outcomes in treatment of iron deficiency anemia during pregnancy. Patients and Methods:The study was conducted on pregnant women attending the antenatal care in the outpatient clinic at Ain-Shams University Maternity Hospital in the period from February 2019 to July 2019, with diagnosis of iron deficiency anemia between 14 -18 weeks with hemoglobin (HB) level 8-10.5g/dL, and serum ferritin <15µg/l. One hundred fifty pregnant women who met the criteria were randomized in to 2 groups (iron chelated amino acid "IAAC" group and ferrous fumarate "FF" group). Hemoglobin level, blood indices, serum iron and serum ferritin levels were measured in both groups at 4, 8, 12 weeks of treatment. Results: There was a significant hematological improvement (mean HB level, blood indices, serum iron and ferritin levels) in both groups which was significantly higher in IAAC group. Conclusion: Iron amino acid chelate achieves faster cure rate than ferrous fumarate in women with iron deficiency anemia in pregnancy as regards mean HB and serum ferritin level. Iron amino acid chelate is associated with fewer side effects than ferrous fumarate.

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Section: Discussionsupporting

confidence: 92%

“…Amino acid chelated iron therapy was reported to have more rapid effect with less GIT side effects [8] and this is what we want to prove in this study.…”

Section: Introductionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Sample Size Justificationmentioning

confidence: 91%

See 2 more Smart Citations

Amino Acid Chelated Iron versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia with Pregnancy : Randomized Controlled Trial

Makled

Abuelghar

El-Shahawy

et al. 2020

Evidence Based Women's Health Journal

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“…Histidine, cysteine, and lysine enhance in vivo iron uptake in segments of rat duodenum [11]. Iron-amino acid chelates provided faster rates of improvement in haemoglobin levels and were better tolerated by the patients than ferrous-fumarate in a randomized controlled study [92]. Multi-amino acid-iron chelates have been used in premenopausal women and preschool children and have shown positive effects in combating iron deficiency and reducing the number of adverse effects [86,93].…”

Section: Usages Advantages and Challenges Of Protein Hydrolysatesmentioning

confidence: 99%

Protein Hydrolysates as Promoters of Non-Haem Iron Absorption

Jiang

Huang

2017

Nutrients

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Iron (Fe) is an essential micronutrient for human growth and health. Organic iron is an excellent iron supplement due to its bioavailability. Both amino acids and peptides improve iron bioavailability and absorption and are therefore valuable components of iron supplements. This review focuses on protein hydrolysates as potential promoters of iron absorption. The ability of protein hydrolysates to chelate iron is thought to be a key attribute for the promotion of iron absorption. Iron-chelatable protein hydrolysates are categorized by their absorption forms: amino acids, di- and tri-peptides and polypeptides. Their structural characteristics, including their size and amino acid sequence, as well as the presence of special amino acids, influence their iron chelation abilities and bioavailabilities. Protein hydrolysates promote iron absorption by keeping iron soluble, reducing ferric iron to ferrous iron, and promoting transport across cell membranes into the gut. We also discuss the use and relative merits of protein hydrolysates as iron supplements.

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AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review

DeLoughery,

Jackson,

et al. 2024

Clinical Gastroenterology and Hepatology

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Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study

Cited by 20 publications

References 10 publications

Amino Acid Chelated Iron versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia with Pregnancy : Randomized Controlled Trial

Amino Acid Chelated Iron versus Ferrous Fumarate in the Treatment of Iron Deficiency Anemia with Pregnancy : Randomized Controlled Trial

Protein Hydrolysates as Promoters of Non-Haem Iron Absorption

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review

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